Correlation of red cell distribution width with inflammatory markers and its prognostic value in patients with diabetes and coronary artery disease

Altaf, Afrasyab; Khan, Miqdad Ali; Alam, Anwar; Khan, Momin; Mahmood, Mazhar; Shah, Hammad; Danish, Naveed; Salahuddin, Momin

doi:10.5603/dk.2020.0017

Cited by 2 publications

(2 citation statements)

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“…In this study, the RDW values achieve a statistically significant difference between the prediabetic and normal groups. RDW is a marker of prognosis and inflammation in patients with diabetes [23]. In the present research, a reduced RDW was linked to a significantly higher risk of developing diabetes.…”

Section: Discussionsupporting

confidence: 58%

Hematological indices and their correlation with glucose control parameters in a prediabetic rat model

et al. 2022

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Background and Aim: Chronic hyperglycemia in prediabetic individuals would progress to diabetes and lead to several systemic disruptions, including hematological parameters. This study aimed to investigate the correlation between prediabetes and hematological indices in a prediabetic rat model. Materials and Methods: Eighteen male rats were randomly divided into two groups of nine. Prediabetes was induced in nine rats by a 3-week high-fat and high-glucose diet, followed by low-dose streptozotocin (STZ) injection (30 mg/ kg body weight). The oral glucose tolerance test was performed, and the fasting blood glucose (FBG) and insulin levels were measured 72 h after STZ administration. The control group of nine rats was given standard diets. At the end of the 3rd week, the animals fasted overnight before blood collection. Blood samples were drawn and used for the analysis of the FBG and fasting insulin levels and glycated albumin to define prediabetes criteria before hematology analysis. Results: We found a significant increase in the FBG and insulin levels in the prediabetic versus the control group. There were decreases in red blood cells, hemoglobin, and hematocrit levels and red cell distribution in prediabetic rats versus the control. At the same time, a significant increase in the platelet count was observed in the prediabetic group. There was a positive correlation between FBG and lymphocytes and neutrophil-lymphocyte ratio in prediabetic rats. On the other hand, we found a negative correlation between white blood cell count and glycated albumin. Conclusion: Correlations were found in several hematological parameters in the prediabetic rat models. The changes in hematological indices in prediabetic rats may be further used as a valuable indicator of glycemic control.

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Section: Discussionsupporting

confidence: 58%

Hematological indices and their correlation with glucose control parameters in a prediabetic rat model

et al. 2022

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“…[ 28 ] Additionally, the relationship between anisocytosis and inflammatory markers has been well-established. [ 29 ] The observed correlation between the RDW–MCV product and the LVMI may be attributed to redox imbalance or inflammatory disorders.…”

Section: Discussionmentioning

confidence: 99%

Prediction of the left ventricular mass index in hypertensive patients using the product of red cell distribution width and mean corpuscular volume

Yu,

Xiong,

Wei

et al. 2024

Medicine

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The product of red cell distribution width (RDW) and mean corpuscular volume (MCV) has been identified as an indicator of target organ damage in cases of hypertension. However, the role of the RDW–MCV product in assessing carotid alteration, renal damage, and left ventricular hypertrophy in patients with hypertension has not been elucidated. In this cross-sectional study, a total of 1115 participants with hypertension were included. The RDW and MCV at admission were measured using an automated hematology analyzer. Organ damage was determined by the left ventricular mass index (LVMI), carotid intima-media thickness, and estimated glomerular filtration rate. The prevalence rates of carotid alteration and left ventricular hypertrophy were 57.0% and 18.0%, respectively. A higher RDW–MCV product and RDW were observed in hypertensive patients who developed carotid alteration. After adjusting for potential confounding factors, the correlations of the RDW-MCV product (P = .285) and RDW (P = .346) with carotid alteration were not significant. Moreover, the analysis of variance showed no significant correlation between RDW and LVMI (P = .186). However, the RDW–MCV product was higher in individuals with a high LVMI compared to those with a normal LVMI. Multivariable linear regression analysis revealed that the RDW–MCV product was independently associated with the LVMI (β = 2.519, 95% CI: 0.921–4.116; P = .002), but not the estimated glomerular filtration rate (β = −0.260, 95% CI: −2.031–1.511; P = .773). An elevated RDW–MCV product may be a predictor for left ventricular hypertrophy in patients with hypertension.

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Correlation of red cell distribution width with inflammatory markers and its prognostic value in patients with diabetes and coronary artery disease

Cited by 2 publications

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Hematological indices and their correlation with glucose control parameters in a prediabetic rat model

Hematological indices and their correlation with glucose control parameters in a prediabetic rat model

Prediction of the left ventricular mass index in hypertensive patients using the product of red cell distribution width and mean corpuscular volume

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