Correlation of rectum‐associated lymph nodules with the development of experimentally induced acute colonic inflammation in rats

Ichikawa, Sanae; Gu, Shouzhi; Yamashita, Akira

doi:10.1046/j.1440-1746.2001.02639.x

Cited by 3 publications

(4 citation statements)

References 14 publications

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“…Rectum-associated lymph nodule (RALN) is an important site for mediating the inflammatory process in the rat colon, corresponding to the Peyer's patch in the intestine. 17 The RALN is formed as a single lymph node tissue in the terminal rectal region of the rat, in contrast to numerous formations of Peyer's patch lymphoid tissue in the intestine. In addition, its structure is similar to that of other peripheral lymphoid tissues and consists of a number of lymphoid follicles in which T and B cells are located in an organized manner.…”

Section: Introductionsupporting

confidence: 74%

“…However, it is difficult to serially follow the developmental process of a single structure such as the Peyer's patch because of its formation at very early stages of development, even in the fetal rat. Rectum‐associated lymph nodule (RALN) is an important site for mediating the inflammatory process in the rat colon, corresponding to the Peyer's patch in the intestine 17 . The RALN is formed as a single lymph node tissue in the terminal rectal region of the rat, in contrast to numerous formations of Peyer's patch lymphoid tissue in the intestine.…”

Section: Introductionmentioning

confidence: 99%

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Expression of adhesion molecules in the rectum‐associated lymph nodules of pre‐ and postnatal specific pathogen‐free rats

Ichikawa¹,

Yamashita²

2003

J of Gastro and Hepatol

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Section: Introductionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Expression of adhesion molecules in the rectum‐associated lymph nodules of pre‐ and postnatal specific pathogen‐free rats

Ichikawa¹,

Yamashita²

2003

J of Gastro and Hepatol

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“…In addition to PPs, there is also an indication of the involvement of other lymphoid follicle structures in IBD manifestations. For instance, lymphoid nodules in the rectum that resemble PPs and contain elevated numbers of macrophages; CD4 + and CD8 + T-cells in mice with DSS-induced colitis, were linked with proximal disease extension [85]. On the other end of the colon, colitis mice with a cecal patch had an enhanced B-cell activation in these patches during the early phase of the disease [86].…”

Section: The Involvement Of Peyer's Patches and Colonic And Cecal Pat...mentioning

confidence: 99%

The Role of the Lymphatic System in the Pathogenesis and Treatment of Inflammatory Bowel Disease

Nikolakis

Voogd

Pruijt

et al. 2022

IJMS

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Although the number of therapeutic options for the treatment of inflammatory bowel disease (IBD) has increased in recent years, patients suffer from decreased quality of life due to non-response or loss of response to the currently available treatments. An increased understanding of this disease’s etiology could provide novel insights for treatment strategies in IBD. Lymphatic system components are generally linked to immune responses and presumably related to inflammatory diseases pathophysiology. This review aims to summarize findings on immune-mediated mechanisms in lymphoid tissues linked with IBD pathogenesis and (potential) novel treatments. Enhanced innate and adaptive immune responses were observed in mesenteric lymph nodes (MLNs) and other lymphoid structures, such as Peyer’s patches, in patients with IBD and in animal models. Furthermore, the phenomenon of lymphatic obstruction in the form of granulomas in MLNs and lymphatic vessels correlates with disease activity. There is also evidence that abnormalities in the lymphatic stromal components and lymph node microbiome are common in IBD and could be exploited therapeutically. Finally, novel agents targeting lymphocyte trafficking have been added to the treatment armamentarium in the field of IBD. Overall, gut-associated lymphoid tissue plays a key role in IBD immunopathogenesis, which could offer novel therapeutic targets.

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“…It is not known if HEV hypertrophy/hyperplasia is always part of activation of MALT, that is, lymphocyte hyperplasia and germinal center development, but it is observed upon antigenic stimulation in lymph nodes and PP. 156 –158…”

Section: Enh High Endothelial Venules Increased or High Endothelial mentioning

confidence: 99%

Nonproliferative and Proliferative Lesions of the Rat and Mouse Hematolymphoid System

Willard-Mack

Elmore

Hall³

et al. 2019

Toxicol Pathol

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The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative changes in rats and mice. The purpose of this publication is to provide a standardized nomenclature for classifying changes observed in the hematolymphoid organs, including the bone marrow, thymus, spleen, lymph nodes, mucosa-associated lymphoid tissues, and other lymphoid tissues (serosa-associated lymphoid clusters and tertiary lymphoid structures) with color photomicrographs illustrating examples of the lesions. Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous lesions as well as lesions induced by exposure to test materials. The nomenclature for these organs is divided into 3 terminologies: descriptive, conventional, and enhanced. Three terms are listed for each diagnosis. The rationale for this approach and guidance for its application to toxicologic pathology are described in detail below.

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Correlation of rectum‐associated lymph nodules with the development of experimentally induced acute colonic inflammation in rats

Cited by 3 publications

References 14 publications

Expression of adhesion molecules in the rectum‐associated lymph nodules of pre‐ and postnatal specific pathogen‐free rats

Expression of adhesion molecules in the rectum‐associated lymph nodules of pre‐ and postnatal specific pathogen‐free rats

The Role of the Lymphatic System in the Pathogenesis and Treatment of Inflammatory Bowel Disease

Nonproliferative and Proliferative Lesions of the Rat and Mouse Hematolymphoid System

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