Correlation of quantitative protein measurements in 8-, 12-, and 24-hour urine samples for the diagnosis of preeclampsia

Adelberg, Amy M.; Miller, Jeff; Doerzbacher, Meg; Lambers, Donna S.

doi:10.1067/mob.2001.117302

Cited by 40 publications

(31 citation statements)

References 6 publications

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“…Subjects who have been placed on long-term bed rest at home or strict bed rest in another hospital for more than 36 h before admission were also excluded because of the decreased correlation between the urine protein-creatine ratio and the 24-h urine protein resulting from prolonged recumbency. 2,6,8,16,17 All eligible subjects (n ¼ 95) received written information before enrollment and 90 agreed to enter the study. A spot clean-catch and midstream voided urine sample was collected from each patient for measurement of protein, creatinine and calcium immediately before routine 24-h urine collection.…”

Section: Methodsmentioning

confidence: 99%

“…[1][2][3][4][5][6] Detecting and quantifying proteinuria is an integral part for both the diagnosis and assessment of severity of these disorders. The presence of significant proteinuria (>300 mg/day) is associated with higher maternal and fetal risks among hypertensive pregnancies.…”

Section: Introductionmentioning

confidence: 99%

“…1,7,8,11,12 Recent studies have, however, shown that this method is inaccurate with high false-positive and negative-results when compared to the gold standard of 24-h urine protein measurement. 1,2,[6][7][8]10,12,13 The latter measurement is also traditionally used for quantifying proteinuria in hypertensive pregnant women but has several limitations. [1][2][3][6][7][8][9][11][12][13][14][15][16][17][18] Most importantly, the laboratory results are not available to the clinician before 24 h, which may delay the ideal strategy for the immediate management of hypertension during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

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Predicting proteinuria in hypertensive pregnancies with urinary protein-creatinine or calcium-creatinine ratio

et al. 2007

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Objective: Evaluate the value of random urinary protein-creatinine (PrCr) and calcium-creatinine (CaCr) ratios to predict 24-h proteinuria in hypertensive pregnancies.Study Design: Spot urine samples were collected before routine 24-h urine collections from consecutive pregnant women with hypertension (n ¼ 83). Reliability of spot urinary PrCr and CaCr to detect significant proteinuria (X300 mg/day) using 24-h urine protein as 'gold-standard' was assessed by receiver-operating characteristic (ROC) curve.Results: Fifty-one patients (61.4%) had significant proteinuria (45 preeclampsia, 5 superimposed pre-eclampsia, 1 renal hypertension). Area under ROC curve to predict proteinuria was 0.82 (95% confidence interval (CI) 0.73 to 0.92, P<0.001) for PrCr and 0.55 (95% CI 0.43 to 0.68, P ¼ 0.2) for CaCr. A cutoff value of >0.19 for PrCr best predicted significant proteinuria with sensitivity, specificity, positive and negative predictive values and likelihood ratios (positive and negative), respectively, of 80.4, 68.8, 80.4, 68.8%, 2.57 and 3.51.Conclusion: Spot urinary PrCr predicts total urinary protein excretion in hypertensive pregnancies.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Predicting proteinuria in hypertensive pregnancies with urinary protein-creatinine or calcium-creatinine ratio

et al. 2007

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“…[14][15][16][17][18][19][20] We conducted a systematic review for relevant studies evaluating the diagnostic utility of a 12-hour urine collection compared with a 24-hour urine collection for the diagnosis of proteinuria in pregnant women with suspected preeclampsia. We then performed a diagnostic meta-analysis of the data to obtain summary diagnostic characteristics and estimate the optimal cutpoint of protein on 12-hour urine collection for the diagnosis of proteinuria.…”

Section: Methods Of Study Selectionmentioning

confidence: 99%

The Utility of 12-Hour Urine Collection for the Diagnosis of Preeclampsia

Stout

Colditz

Macones

et al. 2015

Obstetrics &Amp; Gynecology

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“…A baseline laboratory evaluation should include hepatic enzyme level, platelet count, serum creatinine level and urinary total protein measurement. Urinary protein-to-creatinine ratios predict the 24-hour urine total protein level and may provide a faster, simplified method of estimating proteinuria, providing that the protein values are less than 1 g in 24 hours 38 . In women who have preeclampsia with no suspected progression, all laboratory tests should be conducted weekly 36,39 .…”

Section: Management Of Chronic Hypertension With Superimposed Preeclamentioning

confidence: 99%

Management of Hypertensive Disorders in Pregnancy- An Update

Nahar

Laila

Akhter

et al. 2013

Bangladesh J Obstet Gynaecol

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Hypertensive disorder is the most common medical problem encountered in pregnancy with a high perinatal and maternal mortality & morbidity. According to the onset of hypertension in relation to pregnancy and its duration and the development of proteinuria & convulsion it is categorized into several types. The prognosis depends on duration and severity of hypertension and multi-system involvement. Aim of management is to achieve a gradual and sustained lowering of BP to prevent maternal complications and to allow prolongation of pregnancy for fetal benefit. For management purpose, according to recent NICE clinical guideline gestational hypertension has been classified into mild, moderate and severe hypertension. Till now there is controversy regarding the use of antihypertensives in mild to moderate hypertension. Labetalol, hydralazine & methyldopa are used as first line drugs according to severity of hypertension. Magnesium sulphate is the anticonvulsant of choice and nimodipine is the newer alternative. Obstetric management in all the types of hypertensive disorders is almost same .Expectant management can be considered for women at <34 weeks gestation only in well equipped centers capable of caring very pre-term babies. Antenatal corticosteroid is recommended for enhancing fetal lung maturity. There is a common consensus that the hypertensive patients should be delivered at e37 weeks as there is no benefit in continuing the pregnancy. For women with any type of hypertensive disorders, vaginal delivery should be considered unless cesarean section is required for the usual obstetric indication. DOI: http://dx.doi.org/10.3329/bjog.v25i1.13729 Bangladesh J Obstet Gynaecol, 2010; Vol. 25(1) : 24-32

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Correlation of quantitative protein measurements in 8-, 12-, and 24-hour urine samples for the diagnosis of preeclampsia

Cited by 40 publications

References 6 publications

Predicting proteinuria in hypertensive pregnancies with urinary protein-creatinine or calcium-creatinine ratio

Predicting proteinuria in hypertensive pregnancies with urinary protein-creatinine or calcium-creatinine ratio

The Utility of 12-Hour Urine Collection for the Diagnosis of Preeclampsia

Management of Hypertensive Disorders in Pregnancy- An Update

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