Correlation of PTC Taste Status with Fungiform Papillae Count and Body Mass Index in Smokers and Non-Smokers of Eastern Province, Saudi Arabia

Khan, Asim Mustafa; Al-Jandan, Badr; Bugshan, Amr; Al-Juaid, Khalid; Ali, Saqib; Jameela, Reshma Veerankutty; Madan, Nasser Al; BuHulaiga, Alaa

doi:10.3390/ijerph17165792

Cited by 5 publications

(5 citation statements)

References 25 publications

(40 reference statements)

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“…However, our results did not show a different incidence of sinusitis and rhinitis between PTC non-tasters, tasters, and super-tasters. Nor did PTC non-tasters and tasters differ in smoking habits, in contrast with other studies that have observed effects of smoking on PTC thresholds [15,31]. Regarding sex, although it has been suggested that a higher frequency of super-tasters are female [32], no differences were found in our cohort.…”

Section: Discussioncontrasting

confidence: 99%

“…(2010) in an Italian cohort of normal weight 20–29-year-old females and males [ 12 ]. Studies carried out in older subjects also report that non-tasters are more likely to have a higher BMI than super-tasters [ 10 , 15 , 33 ]. However, other studies have not found any evidence of a relationship between BMI and PTC taster status [ 11 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…In particular, non-tasters females have been reported to have a higher body mass index (BMI) than tasters and super-tasters Open Access *Correspondence: jjmoreno@ub.edu [10,12]. However, only a few studies have analyzed BMI as a continuous variable or its relationship with PTC/ PROP sensitivity [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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Association of phenylthiocarbamide perception with anthropometric variables and intake and liking for bitter vegetables

et al. 2022

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Phenylthiocarbamide (PTC) sensitivity, a sensory trait mediated by the bitter taste receptor 38 (TAS2R38), has been described as a promising biomarker of health status or disease risk. The aim of this cross-sectional study was to evaluate the influence of PTC phenotypes on (1) individual anthropometric and clinical history variables; (2) other basic taste recognition thresholds (RTs), and (3) the hedonic perception and habitual intake of Brassicaceae vegetables in a young adult population (18.9 ± 1.7 years old). The PTC phenotype was determined by the quantitative measure of the PTC recognition threshold (non-tasters, 24.1%; tasters, 52.3%; and super tasters, 23.6%). No significant differences in smoking habits, oral and nasal disorders, family antecedents of diseases related to metabolic syndrome, and Brassicaceae vegetable hedonic perception and consumption were found between the PTC phenotype groups. The average BMI of super-taster females and males was significantly lower compared to non-tasters. In addition, the PTC taster status was a predictor of lower scores for other basic taste RTs. Overall, the defined PTC super-taster cohort could be differentiated from the non-tasters by variables related to weight control such as BMI and sucrose RT.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association of phenylthiocarbamide perception with anthropometric variables and intake and liking for bitter vegetables

et al. 2022

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“…47,48 Likewise, body mass index (BMI) was also inversely associated PTC taste sensitivity. 49 Increased sensitivity to certain bitter substances could indicate a lower quantity of vegetable consumption. 40,41 Contrarily, one study found the AVI/AVI non-taster diplotype to be associated with higher risk of obesity in European Americans and Asians, 50 possibly due to differences in nutrient sensing, energy metabolism, immune responses or reduced sensitivity to sweet taste recognition.…”

Section: Obesitymentioning

confidence: 99%

Clinical Associations of Bitter Taste Perception and Bitter Taste Receptor Variants and the Potential for Personalized Healthcare

Mao¹,

Cheng²,

Li³

et al. 2023

PGPM

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Bitter taste receptors (T2Rs) consist of 25 functional receptors that can be found in various types of cells throughout the human body with responses ranging from detecting bitter taste to suppressing pathogen-induced inflammation upon activation. Numerous studies have observed clinical associations with genetic or phenotypic variants in bitter taste receptors, most notably that of the receptor isoform T2R38. With genetic variants playing a role in the response of the body to bacterial quorum-sensing molecules, bacterial metabolites, medicinal agonists and nutrients, we examine how T2R polymorphisms, expression levels and bitter taste perception can lead to varying clinical associations. From these genetic and phenotypic differences, healthcare management can potentially be individualized through appropriately administering drugs with bitter masking to increase compliance; optimizing nutritional strategies and diets; avoiding the use of T2R agonists if this pathway is already activated from bacterial infections; adjusting drug regimens based on differing prognoses; or adjusting drug regimens based on T2R expression levels in the target cell type and bodily region.

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“…7 Individuals sensitive to PTC are also susceptible to more than 10,000 other tastes, which is not observed in individuals who are not sensitive to PTC. 8 The primary gene responsible for PTC sensitivity is TAS2R38, located on chromosome 7. 9 The polymorphisms of the TAS2R38 bitter taste gene may lead to differences in how the taste of food is sensed.…”

Section: Introductionmentioning

confidence: 99%

Relationship between the TAS2R38 and TAS1R2 polymorphisms and the dental status in obese children

Kiliç¹,

Gürbüz²,

Kahraman³

et al. 2022

Dent. Med. Probl.

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Background. The sweet taste and bitter taste genes are thought to have an influence on obesity and caries, which are chronic diseases.Objectives. The aim of the study was to investigate the effects of the polymorphisms of TAS2R38 (the bitter taste gene) and TAS1R2 (the sweet taste gene), which are the most important members of the taste gene family, on the dental status of obese and normal-weight children. Material and methods.The study included 78 healthy children and 100 children diagnosed with obesity (5-16 years old). The anthropometric measurements and dental status of the children were evaluated. The decayed, missing and filled permanent/primary teeth (DMFT/dmft) index was determined using the standard methods recommended by the World Health Organization (WHO). Blood samples were collected from all subjects and were analyzed via the polymerase chain reaction (PCR) test, with the use of specific primers for the genetic analysis. Five single-nucleotide polymorphisms (SNPs) of the TAS2R38 and TAS1R2 genes were investigated. The truncated Poisson and truncated negative binomial modeling approaches were used with regard to the data.Results. The DMFT/dmft scores were low in obese children and high in children who did not sense the bitter taste (non-tasters). While obese non-taster children had increased DMFT/dmft scores, normalweight non-taster children had decreased DMFT/dmft scores.Conclusions. The alanine, valine and isoleucine (AVI) as well as proline, alanine and valine (PAV) haplotypes of the TAS2R38 gene are associated with the DMFT/dmft index and obesity. This study showed that the DMFT/dmft scores were decreased in obese children. According to the haplotype analysis of the TAS2R38 gene, the DMFT/dmft scores were increased in non-tasters. When differentiating obese nontasters and control non-tasters, DMFT/dmft increased in obese non-taster patients, while it decreased in control non-taster patients.

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Correlation of PTC Taste Status with Fungiform Papillae Count and Body Mass Index in Smokers and Non-Smokers of Eastern Province, Saudi Arabia

Cited by 5 publications

References 25 publications

Association of phenylthiocarbamide perception with anthropometric variables and intake and liking for bitter vegetables

Association of phenylthiocarbamide perception with anthropometric variables and intake and liking for bitter vegetables

Clinical Associations of Bitter Taste Perception and Bitter Taste Receptor Variants and the Potential for Personalized Healthcare

Relationship between the TAS2R38 and TAS1R2 polymorphisms and the dental status in obese children

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