Correlation of psoriasis severity with angiographic coronary artery disease complexity: a Cross‐Sectional study

Sofidis, Georgios; Stalikas, Nikolaos; Papathemeli, Despoina; Karagiannidis, Efstratios; Κάρτας, Αναστάσιος; Papazoglou, Αndreas S.; Otountzidis, Nikolaos; Natsis, Konstantinos; Lazaridou, E.; Patsatsi, Aikaterini; Sianos, George

doi:10.1111/jdv.17143

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“…The risk of major adverse cardiac events is particularly high among patients with severe psoriasis (up to 1.42 hazard ratio) 11 , adjusting for other risk factors (including diabetes and hyperlipidemia). Furthermore, CAD has been found to be associated with Psoriasis Area and Severity Index (PASI) 12 ; treatments which lower PASI can also improve coronary plaque 13 – 15 and vascular inflammation 16 . The ACC/AHA guidelines for the prevention of cardiovascular disease list psoriasis as a risk-enhancing factor 17 , however until now there has been limited research to reveal the causal relationship between psoriasis and CAD.…”

Section: Introductionmentioning

confidence: 99%

Shared genetic risk factors and causal association between psoriasis and coronary artery disease

et al. 2022

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Psoriasis and coronary artery disease (CAD) are related comorbidities that are well established, but whether a genetic basis underlies this is not well studied. We apply trans-disease meta-analysis to 11,024 psoriasis and 60,801 CAD cases, along with their associated controls, identifying one opposing and three shared genetic loci, which are confirmed through colocalization analysis. Combining results from Bayesian credible interval analysis with independent information from genomic, epigenomic, and spatial chromatin organization, we prioritize genes (including IFIH1 and IL23A) that have implications for common molecular mechanisms involved in psoriasis and CAD inflammatory signaling. Chronic systemic inflammation has been associated with CAD and myocardial infarction, and Mendelian randomization analysis finds that CAD as an exposure can have a significant causal effect on psoriasis (OR = 1.11; p = 3×10−6) following adjustment for BMI and waist-hip ratio. Together, these findings suggest that systemic inflammation which causes CAD can increase the risk of psoriasis.

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Section: Introductionmentioning

confidence: 99%

Shared genetic risk factors and causal association between psoriasis and coronary artery disease

et al. 2022

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Correlation of psoriasis severity with angiographic coronary artery disease complexity: a Cross‐Sectional study

Abstract: Anti-p200 pemphigoid is the most common pemphigoid disease with serum antibodies against the dermal side by indirect immunofluorescence microscopy on human salt-split skin.

Cited by 1 publication

References 10 publications

Shared genetic risk factors and causal association between psoriasis and coronary artery disease

Shared genetic risk factors and causal association between psoriasis and coronary artery disease

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