Correlation of progression of diabetic retinopathy with the alterations in retrobulbar circulation

Sood, Sunandan; Narang, Subina; Kocchhar, S; Sarda, Sujata P.; Aggarwal, Sarita; Arya, SK

doi:10.3126/nepjoph.v5i2.8705

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…No significant differences in the PSV of the OA were found between the 3 groups of pregnant women in this study. Our findings were similar to those of other authors who studied the PSV behavior in the OA of nonpregnant diabetic patients with retinopathy 9,11,12,25 . The EDV was significantly lower in the group of pregnant women with retinopathy.…”

Section: Discussionsupporting

confidence: 92%

Doppler Indices of the Ophthalmic Artery in Pregnant Women With Pregestational Diabetes Mellitus With and Without Retinopathy

Anjos

Freitas

Santos

et al. 2020

J of Ultrasound Medicine

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Objectives To evaluate ophthalmic Doppler velocimetry patterns in pregnant women with pregestational diabetes mellitus with and without retinopathy in comparison to pregnant women without gestational intercurrences. Methods This cross‐sectional observational study analyzed Doppler indices of the ophthalmic arteries, including the resistive index (RI), pulsatility index, peak systolic velocity, second peak systolic velocity, peak ratio, and end‐diastolic velocity (EDV), in 3 groups of pregnant women: diabetic with retinopathy (n = 12); diabetic without retinopathy (n = 85); and nondiabetic controls (n = 122). The Kruskal‐Wallis test was used for the statistical analysis with a probability of 95%. Results The mean gestational ages ± SDs of pregnant women with and without retinopathy and nondiabetic controls were 29.1 ± 2.2, 29.7 ± 2.7, and 31 ± 1.0 weeks, respectively, with no significant differences between the groups (P > .099). The mean RI in the group with retinopathy was significantly higher (P = .030) than in the control group, but it did not significantly differ compared to the group without retinopathy (P = .204). The RI in the control group did not differ from that in the group without retinopathy (P = .079). The EDV was significantly lower in the group with retinopathy (P = .015) in relation to the control group, but there were no differences compared to the group without retinopathy (P = .217). Conclusions Pregnant women with pregestational diabetes mellitus and retinopathy had increased vascular impedance in the ophthalmic artery together with a reduction in the EDV, which was probably related to ischemia, thrombosis, and neovascularization of retinal vessels.

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Section: Discussionsupporting

confidence: 92%

Doppler Indices of the Ophthalmic Artery in Pregnant Women With Pregestational Diabetes Mellitus With and Without Retinopathy

Anjos

Freitas

Santos

et al. 2020

J of Ultrasound Medicine

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“…Reduced blood flow velocity was found in the CRA of diabetic patients and appeared to become further reduced with the progression of retinopathy [18, 19]. Significant changes in retrobulbar blood flow were found in eyes without and with DR, especially those with retinopathy [20, 21]. Significant circulatory changes were found in the OA, CRA and short posterior ciliary artery in diabetic patients with DR [22].…”

Section: Discussionmentioning

confidence: 99%

Resistive index of central retinal artery is a bioimaging biomarker for severity of diabetic retinopathy

et al. 2019

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BackgroundThe present study was undertaken to assess the resistive index (RI) of central retinal artery (CRA) as a bioimaging biomarker for the severity of diabetic retinopathy (DR), for the first time.MethodsEighty-one consecutive patients of type 2 diabetes mellitus between the ages of 40 and 70 years were included in a tertiary care center-based cross sectional study. Severity of retinopathy was assessed according to Early Treatment Diabetic Retinopathy Study (ETDRS) classification: diabetes mellitus with no retinopathy (No DR) (n = 26); non-proliferative diabetic retinopathy (NPDR) (n = 29); and proliferative diabetic retinopathy (PDR) (n = 26). Twenty-six healthy controls of similar age were also included. Resistive index of CRA was studied using color Doppler and gray scale sonography. Central subfield thickness (CST), cube average thickness (CAT), retinal photoreceptor ellipsoid zone (EZ) disruption, and retinal nerve fiber layer (RNFL) thickness were evaluated using spectral domain optical coherence tomography. Sensitivity and specificity were assessed by receiver operating characteristic (ROC) curve.ResultsMean RI of CRA for the study groups revealed significant increase with severity of diabetic retinopathy (F = 10.24, P < 0.001). The ROC curve analysis showed diagnostic accuracy of RI of CRA (area under curve = 0.841–0.999; sensitivity = 76–100%, specificity = 95.45–100%, P < 0.001) in discriminating controls and patients. Univariate regression analysis revealed significant association between the study groups and RI of CRA (P < 0.001). RI of CRA correlated positively with CST (r = 0.37), CAT (r = 0.45), EZ disruption (r = 0.43) and negatively with RNFL thickness (r = − 0.35) (P < 0.001).ConclusionsResistive index of CRA is a reliable bioimaging biomarker for the severity of DR.

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Measurement of Geometrical and Functional Parameters Related to Ocular Blood Flow

Gross

Prada

2019

Ocular Fluid Dynamics

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Correlation of progression of diabetic retinopathy with the alterations in retrobulbar circulation

Abstract: The retrobulbar arterial circulation seems to be affected in all diabetics with DR. The changes appear to be progressive. The CDI findings in arterial circulation however lack predictive power for progression of diabetic retinopathy in non proliferative DR.

Cited by 4 publications

References 14 publications

Doppler Indices of the Ophthalmic Artery in Pregnant Women With Pregestational Diabetes Mellitus With and Without Retinopathy

Doppler Indices of the Ophthalmic Artery in Pregnant Women With Pregestational Diabetes Mellitus With and Without Retinopathy

Resistive index of central retinal artery is a bioimaging biomarker for severity of diabetic retinopathy

Measurement of Geometrical and Functional Parameters Related to Ocular Blood Flow

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