Correlation of Point-of-Care International Normalized Ratio to Laboratory International Normalized Ratio in Hemodialysis Patients Taking Warfarin

Utilization of Coagulation Assays in Clinical Therapeutics

“…In addition to laboratory analysis of a venous blood sample, the emergence of point‐of‐care (POC) INR testing of a whole blood sample from a finger prick has provided more convenient INR monitoring for both patients and providers. In general, the literature supports that these POC devices can reliably monitor INR and that they correlate well with laboratory analysis . INR results can be affected by abnormal hematocrit, clotted specimens, time to perform assay, anticoagulant contamination, and improper blood sample …”

“…In general, the literature supports that these POC devices can reliably monitor INR and that they correlate well with laboratory analysis. [15][16][17] INR results can be affected by abnormal hematocrit, clotted speci- mens, time to perform assay, anticoagulant contamination, and improper blood sample. 8 The INR is not the ideal assay for patients with liver disease because the results can be misinterpreted.…”

Comparison of the CoaguChek XS Handheld Coagulation Analyzer and Conventional Laboratory Methods Measuring International Normalised Ratio (INR) Values during the Time to Therapeutic Range after Mechanical Valve Surgery

“…In previous studies, test results measured with POC devices sometimes were affected by hematocrit values, heparin use, and antiphospholipid antibodies . Hoel et al found that POC INRs correlated well with plasma INR measures in hemodialysis patients, and that anemia did not influence this correlation. In the same study, it was found that the cost of INR determination using the POC device was less than with the traditional method ($2.06 vs. $2.12 per patient) …”

A Comparison of Coagulation Study Results Between Heparinized Peripherally Inserted Central Catheters and Venipunctures

“…15Y17 Two of those studies focused on hemodialysis patients. 15, 16 Hoel and colleagues 15 found high levels of agreement on Bland-Altman analysis and strong correlations between fingerstick point-of-care blood samples and samples drawn from a dialysis access device (graft, fistula, or central catheter) in the 340 paired samples they collected. Rioux and colleagues 16 compared blood samples drawn from a heparinized central catheter and VP in 30 patients.…”