Correlation of plasma N-terminal pro-brain natriuretic peptide levels with left ventricle mass in children treated with anthracyclines

Germanakis, Ioannis; Kalmanti, Maria; Parthenakis, F.; Nikitovic, Dragana; Stiakaki, Eftichia; Patrianakos, Alexandros; Vardas, Panos

doi:10.1016/j.ijcard.2005.05.006

Cited by 61 publications

(46 citation statements)

References 20 publications

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“…Currently there is no optimal method that can be used for early detection of subclinical late cardiotoxicity. The role of biochemical cardiomarkers that reflect cardiomyocyte degeneration (serum levels of cTnT) and functional myocardial changes (serum levels of NT-proBNP) in early detection of cardiotoxicity of cytostatics have been evaluated in many clinical and experimental studies [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

“…The clinical value of cTn and NPs measurement in diagnosis of heart failure during and after the anticancer treatment has been evaluated in several studies with adults and children [7,9,13,14,[22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

“…Dose of CNS radiation (Gy) 18 (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) Values are presented as median (range). * patients previously treated with anthracyclines ‡ acute lymphoblastic leukemia § acute myeloblastic leukemia …”

Section: Cns Radiation 17mentioning

confidence: 99%

“…Biochemical cardiomarkers that reflect cardiomyocyte degeneration (serum levels of cardiac troponin T -cTnT) and functional myocardial changes (serum levels of N-terminal fragment of the brain natriuretic peptide precursor -NT-proBNP) of cancer patients treated with potentially cardiotoxic therapy have been evaluated in several clinical and experimental studies [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. However only little information is available about the usefulness of biomarkers CTnT and NTproBNP in detection of late anthracycline cardiotoxicity (more than 5 years after diagnosis) in survivors of pediatric leukemia.…”

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confidence: 99%

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Long-term cardiac effects of treatment for childhood leukemia

Urbanová

Urbán²,

Šimková³

et al. 2010

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Late cardiac complications in cancer survivors may develop from subclinical myocardial damage. Biochemical correlates of minimal myocardial changes can be analyzed using a commercially available rapid assay. Biomarkers are considered more sensitive markers of subclinical cardiotoxicity than conventional electrocardiographic and echocardiographic methods.The aim of this study was to determine the values of plasma N-terminal pro brain natriuretic peptide (NT-pro-BNP) and cardiac troponin T (cTnT) in asymptomatic childhood leukemia survivors after anthracycline therapy in comparison with healthy volunteers. The survivors also underwent a detailed echocardiography.Twenty six survivors of leukemia previously treated with anthracyclines with total cumulative dose 95-600 (median 221) mg/m 2 were evaluated. Analyses of cTnT and NT-proBNP from blood samples and echocardiography were performed 5-25 years after completion of therapy for childhood leukemia. Control group for biochemical analyses consisted of 22 age-and gender-matched apparently healthy volunteers.Values of NT-proBNP were significantly elevated in ANT group compared to controls (35.1 ± 37.8 vs. 9.6 ± 6.7 pg/ml, P<0.010). CTnT remained below the diagnostic cut-off values in both groups. All echocardiographic parameters of patients remained normal.In conclusion, differences in NT-proBNP values between patients treated with anthracyclines and healthy volunteers might signal an initial stage of anthracycline-induced myocardial damage. The potential of this biomarker to detect subclinical anthracycline-induced myocardial alterations before development of echocardiographic and clinical changes is promising. Key words: cardiotoxicity, natriuretic peptides, cardiac troponins, anthracyclines, echocardiographyNeoplasma 57, 2, 2010 doi:10.4149/neo_2010_02_179Abbreviations: ANT group -patients previously treated with anthracyclines; cTn -cardiac troponins; cTnT -cardiac troponinT; NPs -natriuretic peptides; NT-proBNP -N-terminal fragment of the brain natriuretic peptide precursor; LV -left ventricular; LVEDD -left ventricular end-diastolic diameter; LVESD -left ventricular end-systolic diameter; LA -left atrium dimension; RV -right ventricular dimension; EF -ejection fraction; E -early diastolic flow velocity; A -late diastolic flow velocity; DT -deceleration time; IVRT -left ventricular isovolumetric relaxation time; TDI -tissue Doppler imaging; Ea -early diastolic velocity of the medial mitral annulus; Em; Sa -systolic velocity; Am -late diastolic velocity

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Cns Radiation 17mentioning

confidence: 99%

mentioning

confidence: 99%

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Long-term cardiac effects of treatment for childhood leukemia

Urbanová

Urbán²,

Šimková³

et al. 2010

neo

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“…Aber auch mit medikamentöser Therapie kann die Herzinsuffizienz fortschreiten und eine Herztransplantation erfordern. Leider bestehen kaum Emp- [29][30][31][32][33][34][35][36]. Am spezifischsten und sensitivsten ist nach wie vor die Endomyokardbiopsie, welche aber als invasive Untersuchung nicht immer angewendet werden kann.…”

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