Correlation of Patterns of Bone Marrow Infiltration and Biochemical factors in Non-Hodgkin Lymphoma

Mazher, Naghmana; Ahmad, Nisar; Iqbal, Zafar

doi:10.12669/pjms.332.11335

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…Originating from the MHC, serum B2M concentrations not only reflect renal function but also are linked to viral infections [160,161], inflammation [155] and various types of malignancy [162,163], where elevated levels have been reported. The ratio of cystatin C and B2M in simultaneous blood samples has been proposed as a diagnostic parameter for post-transplant lymphoproliferative disease [164].…”

Section: Physiologymentioning

confidence: 99%

Endogenous markers for kidney function in children: a review

Bakker

Gemke

Bökenkamp

2018

Critical Reviews in Clinical Laboratory Sciences

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Although glomerular filtration rate (GFR) in children can be measured using a gold-standard technique following injection of an exogenous marker, this invasive and cumbersome technique is not widely available and GFR is commonly estimated using serum levels of endogenous markers. Creatinine, urea, cystatin C, beta-trace protein, and beta-2 microglobulin are well-established endogenous markers of kidney function. These markers differ in site of production and effects of diet and medication, as well as renal-tubular handling and extra-renal elimination. For each marker, different methods are available for measurement. Importantly, the measurements of creatinine and cystatin C have recently been standardized with the introduction of international reference standards. In order to allow estimation of GFR from serum marker concentrations, different equations for estimated GFR (eGFR) have been developed in children, using simple or more complex regression strategies with gold standard GFR measurements as a dependent variable. As a rule, estimation strategies relying on more than one marker - either by calculating the average of single parameter equations or by using more complex equations incorporating several parameters - outperform eGFR estimations using only a single marker. This in-depth review will discuss the physiology, measurement and clinical use of creatinine, urea, cystatin C, beta-trace protein, and beta-2 microglobulin in children. It will also address the generation of eGFR equations in children and provide an overview of currently available eGFR equations for the pediatric age group.

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Section: Physiologymentioning

confidence: 99%

Endogenous markers for kidney function in children: a review

Bakker

Gemke

Bökenkamp

2018

Critical Reviews in Clinical Laboratory Sciences

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“…Lymphomas can be broadly classified as HL and NHL 4 and high prevalence of the disease has been reported in the regions including Southwest Asia, Middle East and North Africa 5 , comprises Pakistan as well and collectively called as Lymphoma belt. HL is reportedly the seventh most common tumor in Pakistan and ranks second among the pediatric population 6 while NHL is the fourth most frequently diagnosed and fifth leading cause of cancer death in Pakistan 7 .…”

Section: Introductionmentioning

confidence: 99%

Incidence and clinicohematological profile of lymphomas in Southern Punjab Pakistan

Saleem

Naveed

Batool

et al. 2020

Int. j. endorsing health sci. res.

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Background: Lymphomas are ranked as the sixth most common malignancy worldwide. Endorsing a significant impact on the health sector among the developing countries like Pakistan. The aim of the current study was to estimate the burden and clinicopathological features of lymphomas in one of the major referral centres in Southern Punjab Pakistan. Methodology: A descriptive cross-sectional study was conducted at the Pathology department of Nishtar Medical University, Multan January 2016 to August 2019. A total of 75 patients both males and females of all age groups with diagnosed lymphoma were enrolled in the study. Diagnosis was made on morphology and immunohistochemistry of lymph node and cases with complete immunohistochemical workup were included and those without immunohistochemical panel were excluded from the study. Baseline tests were performed and bone marrow specimens were extracted from all cases. The data was analyzed using SPSS Version 23.0. Results: Out of the total, 22.6% patients had Hodgkin lymphoma (HL) and 77.4% had Non-Hodgkin lymphoma (NHL). Classical Hodgkin lymphoma (CHL) was the most frequent histology (94%) among HL patients while Diffuse large B cell lymphoma (DLBCL) was the commonest B cell NHL (29.3%) and T cell lymphoblastic lymphoma (T-LBL) was found to be the most common T cell variant (5.3%). B symptoms, splenomegaly and hepatomegaly were documented in 96%, 42.7% and 25.3% patients respectively. Moreover, the disease was nodal in 65% cases and extranodal presentation was observed in 35% of the cases. Cervical node (lymph node) was involved in 25.3% of the cases while bone marrow was involved in 53.3% cases. The patterns of bone marrow infiltration were para trabecular (24.3%), diffuse (22.5%), interstitial (1.8%) and mixed pattern (3.75%). Conclusion: Lymphomas are relatively more common among younger population in Pakistan. NHLs constitute more than 2/3rd of all lymphomas with DLBCL as the commonest histology. Stage IV disease as evidenced by bone marrow infiltration is seen in more than half of our patients.

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Correlation of Patterns of Bone Marrow Infiltration and Biochemical factors in Non-Hodgkin Lymphoma

Cited by 2 publications

References 19 publications

Endogenous markers for kidney function in children: a review

Endogenous markers for kidney function in children: a review

Incidence and clinicohematological profile of lymphomas in Southern Punjab Pakistan

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