Correlation of p53 and Ki‐67 (MIB‐1) expressions with clinicopathological features and prognosis of early stage cervical squamous cell carcinomas

Hanprasertpong, Jitti; Tungsinmunkong, Kobkul; Chichareon, Saibua; Wootipoom, Virach; Geater, Alan; Buhachat, Rakchai; Boonyapipat, Sathana

doi:10.1111/j.1447-0756.2010.01227.x

Cited by 18 publications

(22 citation statements)

References 27 publications

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“…Hunt et al's study [4] showed the corresponding figures as 33 and 36 %, respectively. There was no relation between p53 overexpression and prognosis in cervical cancer [4,8]. The present study shows lack of relationship between p53 overexpression and prognosis in the cervical cancer patients.…”

Section: P53 Expression and Histopathology Of Cervical Cancercontrasting

confidence: 69%

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The Role of p53 Gene in Cervical Carcinogenesis

Garima

Pandey

et al. 2015

J Obstet Gynecol India

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Aim To investigate the role of p53 gene in cervical carcinogenesis. Materials and Methods A total 50 cases and controls were taken after setting exclusion criteria. Venous blood (3 ml) samples were collected in sterile EDTA sterile vials. Both punch biopsy of cervical growth in cases and biopsy from cervix after hysterectomy in controls were performed. Genomic DNA was extracted from tissue and blood using standard protocol of Miller et al. 1994 using chloroformphenol method. Gene was amplified using specific forward and reverse primers and p53 gene expressions were studied. The present study of p53 gene regulation analyzed the expression of 279-bp bands on 1.5 agarose gel. Observations Out of the total 50 samples of cases and controls, we were able to isolate DNA from 38 cases and 28 controls in blood and in 22 cases and 22 controls in tissue. In cases of carcinoma cervix, p53 expression is either downregulated or absent in 71.06 % of cases compared to 50 % of controls in blood and 72.73 % of cases compared to 59.09 % of controls in tissue, but these figures were not statistically significant (p = 0.67 and p = 0.167, respectively). p53 positivity rate was only in 27.78 % of squamous cell cancer and 50 % of adenocarcinoma. Three out of nine patients (33.3 %) with L.N. positive status have p53 gene positivity, whereas 23 % (3

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Section: P53 Expression and Histopathology Of Cervical Cancercontrasting

confidence: 69%

“…In the present study, p53 upregulation was found in 28.94 % of cases in blood and 27.27 % of tissue. p53 overexpression was present in 25.5 % of cases in Oka et al's study [7], 33.6 % in Hanprasertpong J et al's study [8], and 14.0 % in Busby-Earle et al's study [9].…”

Section: Observationsmentioning

confidence: 84%

The Role of p53 Gene in Cervical Carcinogenesis

Garima

Pandey

et al. 2015

J Obstet Gynecol India

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“…As an established marker for cell proliferation, Ki67 has been suggested to be a predictor for high-risk HPV infection and an independent prognostic parameter for recurrence-free survival of CC (16,17). Our findings showed that the Ki67-positive cells were mainly located in the surrounding areas of cancer nests or in invaded cancerous tissues, implying active growth of the cells in these areas.…”

Section: Discussionmentioning

confidence: 54%

Peroxiredoxin 3 is a novel marker for cell proliferation in cervical cancer

Gao

2012

Biomedical Reports

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Abstract. Although peroxiredoxin 3 (Prx3) has been reported to be involved in cervical cancer (CC) carcinogenesis, the significance of Prx3 in CC progression remains unclear. The present study was conducted to investigate the expression features of Prx3 to better understand the mechanism of tumor growth and invasion. Sixty-eight patients with invasive squamous cervical cancer were included in the present study. The status of human papillomavirus (HPV) infection was detected by hybridization and quantitative real-time polymerase chain reaction (qRT-PCR). Immunohistochemistry was performed on paraffin-embedded sections using monoclonal antibodies against Prx3 and Ki67. All samples were positive for high-risk HPV, among which fifty-six samples were positive for HPV16, seven for HPV18 and five for HPV33. The expression of HPV16 E6/E7 was significantly higher in cancer areas compared to the adjacent normal epithelial tissuses. The positive cells for Prx3 and Ki67 were significantly higher in cancer cells compared to normal epitheliums and the staining pattern of Prx3 was consistent with that of Ki67 (Pearson's correlation coefficient was 0.801, P= 0.000). The upregulation of Prx3 might be a protective response to oxidative stress in the cancer microenvironment. The expression consistency of Prx3 and Ki67 suggests Prx3 to be a potential marker for cell proliferation of CC.

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“…In patients with cervical SCC, Hanprasertpong et al (90) found Ki-67 expression in 81.3% of cases and p53 expression in 33.6%. There was a significant correlation between p53 and Ki-67.…”

Section: Biomarkers For the Prognostic Prediction Of Cervical Cancermentioning

confidence: 99%

Candidate biomarkers for cervical cancer treatment: Potential for clinical practice (Review)

Iida

Banno

Yanokura

et al. 2014

Molecular and Clinical Oncology

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Abstract. Cervical cancer ranks high among the causes of female cancer mortalities and is an important disease in developing and developed countries. Current diagnosis of cervical cancer depends on colposcopy, pathological diagnosis and preoperative diagnosis using methods, including magnetic resonance imaging and computed tomography. Advanced cervical cancer has a poor prognosis. The tumor marker squamous cell carcinoma is conventionally used for screening, but recent studies have revealed the mechanisms of carcinogenesis and the factors associated with a poor prognosis in cervical cancer. These include epigenetic biomarkers, with the methylation level of the checkpoint with forkhead and ring finger gene being potentially useful for predicting the malignancy of cervical cancer and sensitivity to treatment with paclitaxel.

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Correlation of p53 and Ki‐67 (MIB‐1) expressions with clinicopathological features and prognosis of early stage cervical squamous cell carcinomas

Abstract: Ki-67 expression is an independent prognostic parameter for RFS in patients with early stage squamous cell carcinoma of the uterine cervix. Ki-67 expression at or above the cut-off point of 30.0% had significantly poorer RFS.

Cited by 18 publications

References 27 publications

The Role of p53 Gene in Cervical Carcinogenesis

The Role of p53 Gene in Cervical Carcinogenesis

Peroxiredoxin 3 is a novel marker for cell proliferation in cervical cancer

Candidate biomarkers for cervical cancer treatment: Potential for clinical practice (Review)

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