Correlation of oxidative stress with activity of matrix metalloproteinase in patients with coronary artery disease Possible role for left ventricular remodelling

Kameda, Kunihiko; Matsunaga, Toshiro; Abe, Naoki; Hanada, Hiroyuki; Ishizaka, Hiroshi; Ono, Hirotsugu; Saitoh, Masayuki; Fukui, Kozo; Fukuda, Ikuo; Osanai, Tomohiro; Okumura, Ken

doi:10.1016/j.ehj.2003.09.022

Cited by 144 publications

(84 citation statements)

References 26 publications

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“…Gelatinases A and B (MMP-2 and -9) are responsible for IV type collagen, gelatin and laminin degradation, vasculature remodeling, angiogenesis, inflammation and then they are involved in the atherosclerotic process [10,24]. Once they are secreted in the extracellular space, MMPs may be activated by several proteases, other MMPs, and ROS, in particular peroxynitrite [1,15,16]. Some authors have described an overexpression of MMP-9 in older atherosclerotic lesions [20], responsible for a large remodeling characterized by fibrosis, matrix degradation and angiogenesis, resulting in plaque instability and rupture [11,20].…”

Section: Introductionmentioning

confidence: 99%

Gelatinases and their tissue inhibitors in a group of subjects with obstructive sleep apnea syndrome

Hopps¹,

Canino²,

Montana

et al. 2016

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Abstract. Obstructive sleep apnea syndrome (OSAS) is associated with an elevated risk of cardiovascular events and stroke. Matrix metalloproteinases (MMPs) are endopeptidases involved in extracellular matrix degradation and then in the development and progression of cardiovascular diseases. Our aim was to evaluate plasma levels of gelatinases (MMP-2 and MMP-9) and their tissue inhibitors (TIMP-1 and TIMP-2) in a group of subjects with OSAS. We enrolled 48 subjects (36 men and 12 women; mean age 49.7 ± 14.68 yrs) with OSAS diagnosed with a 1-night cardiorespiratory study and then we subdivided these subjects into two subgroups according to the apnea/hypopnea index (AHI): Low (L = 21 subjects with AHI <30) and High (H = 27 subjects with AHI >30). We measured plasma concentration of the gelatinases and their inhibitors using ELISA kits. We observed a significant increase in plasma concentration of MMP-9, MMP-2, TIMP-1 and TIMP-2 in the entire group of OSAS subjects and in the two subgroups, with higher levels in the H in comparison with the L subgroup. In the whole group of OSAS subjects we also noted a significant decrease in MMP-9/TIMP-1 ratio in comparison with normal controls. Only MMP-9 was significantly correlated with the severity of the disease, expressed as AHI, with the oxygen desaturation index and also with the mean oxygen saturation. MMPs pattern is altered in OSAS and significantly influenced by the severity of the disease; it probably contributes to the vascular remodeling that leads to the atherosclerotic disease and cardiovascular complications.

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Section: Introductionmentioning

confidence: 99%

Gelatinases and their tissue inhibitors in a group of subjects with obstructive sleep apnea syndrome

Hopps¹,

Canino²,

Montana

et al. 2016

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“…Rajagopalan et al (1996) reported that both MMP-2 and MMP-9 activities in cultured smooth muscle cells were increased by reactive oxygen species produced by macrophage-derived foam cells. Kameda et al (2003) showed the correlation of oxidative stress with activities of MMPs in patients with coronary artery disease. Uemura et al (2001) demonstrated that vascular MMP-9 activity was increased in diabetes due to oxidative A.…”

Section: Resultsmentioning

confidence: 99%

Copper decreases gene expression of TNF-α, IL-10, and of matrix metalloproteinases MMP-2 and MMP-9 in isolated perfused rat livers

et al. 2007

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Abstract:Copper is known to induce oxidative stress in a number of models. It was shown that many pathophysiological events were associated with oxidative stress. Further, oxidative stress can increase gene expression of cytokines and of metalloproteinases. We previously found that copper toxic effects in isolated perfused rat livers were associated with significant oxidative stress (as assessed by lipid peroxidation, protein oxidation and oxidative DNA damage, particularly at concentration of 0.03 mM of Cu 2+ in the perfusate). Here we investigated gene expression of tumor necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in frozen liver tissue samples by the real-time PCR assay. Compared to controls, copper at concentration of 0.01 mM did not affect gene expression of TNF-α, IL-10, MMP-2 and MMP-9, whereas copper at concentration of 0.03 mM significantly decreased gene expression of all the four TNF-α, IL-10, MMP-2 and MMP-9 by 69%, 81%, 43%, and 62%, respectively. These results suggest that copper-induced oxidative stress in the isolated rat liver can lead to the suppression of gene expression. Because TNF-α and metalloproteinases are involved also in liver regeneration, the suppression of these genes by copper may be one of the mechanisms by which acute intoxication of animals and humans with copper may impair regenerative capability of the liver.

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“…Aunque no exista un marcador directo de estrés oxidativo medible en sangre, existen marcadores indirectos como los niveles plasmáticos de LDL oxidada, malondialdehído, mieloperoxidasa e isoprostano, estos dos últimos con excelente correlación con la gravedad siendo predictores independientes de mortalidad 4,37 . Sin embargo, su uso se encuentra limitado a estudios de investigación.…”

Section: Marcadores De Estrés Oxidativounclassified

Utilidad de los biomarcadores en insuficiencia cardiaca en la práctica clínica

C¹,

Vega²,

León³

et al. 2013

Rev. méd. Chile

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Correlation of oxidative stress with activity of matrix metalloproteinase in patients with coronary artery disease Possible role for left ventricular remodelling

Abstract: Oxidative stress may play an important role in the regulation of MMP activity. Augmented MMP activity may be involved in the development of ventricular remodelling in patients with coronary artery disease.

Cited by 144 publications

References 26 publications

Gelatinases and their tissue inhibitors in a group of subjects with obstructive sleep apnea syndrome

Gelatinases and their tissue inhibitors in a group of subjects with obstructive sleep apnea syndrome

Copper decreases gene expression of TNF-α, IL-10, and of matrix metalloproteinases MMP-2 and MMP-9 in isolated perfused rat livers

Utilidad de los biomarcadores en insuficiencia cardiaca en la práctica clínica

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