Correlation of ovarian reserve tests with histologically determined primordial follicle number

Hansen, Karl R.; Hodnett, George M.; Knowlton, Nicholas; Craig, LaTasha B.

doi:10.1016/j.fertnstert.2010.04.006

Cited by 471 publications

(290 citation statements)

References 46 publications

(64 reference statements)

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“…The slow changes in AMH levels suggest that it regulates the long-term processes, across the lifespan. Correlation studies suggest that the size of the developing follicle pool is the primary determinant of AMH concentrations in women (Fanchin et al 2003, Hansen et al 2011, Bentzen et al 2013. In essence, the AMH-responsive cells (outside of early developing follicles) are being regulated by the size of the developing follicle pool.…”

Section: Anti-müllerian Hormone Expression In the Ovarymentioning

confidence: 99%

A putative role for anti-Müllerian hormone (AMH) in optimising ovarian reserve expenditure

Pankhurst

2017

Journal of Endocrinology

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The mammalian ovary has a finite supply of oocytes, which are contained within primordial follicles where they are arrested in a dormant state. The number of primordial follicles in the ovary at puberty is highly variable between females of the same species. Females that enter puberty with a small ovarian reserve are at risk of a shorter reproductive lifespan, as their ovarian reserve is expected to be depleted faster. One of the roles of anti-Müllerian hormone (AMH) is to inhibit primordial follicle activation, which slows the rate at which the ovarian reserve is depleted. A simple interpretation is that the function of AMH is to conserve ovarian reserve. However, the females with the lowest ovarian reserve and the greatest risk of early reserve depletion have the lowest levels of AMH. In contrast, AMH apparently strongly inhibits primordial follicle activation in females with ample ovarian reserve, for reasons that remain unexplained. The rate of primordial follicle activation determines the size of the developing follicle pool, which in turn, determines how many oocytes are available to be selected for ovulation. This review discusses the evidence that AMH regulates the size of the developing follicle pool by altering the rate of primordial follicle activation in a context-dependent manner. The expression patterns of AMH across life are also consistent with changing requirements for primordial follicle activation in the ageing ovary. A potential role of AMH in the fertility of ageing females is proposed herein.

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Section: Anti-müllerian Hormone Expression In the Ovarymentioning

confidence: 99%

A putative role for anti-Müllerian hormone (AMH) in optimising ovarian reserve expenditure

Pankhurst

2017

Journal of Endocrinology

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“…Following an incremental increase in AMH levels throughout a women's reproductive time span, there is a steady decline in levels until it becomes undetectable, which correlates with the onset of menopause [7]. This rise and fall of the AMH level corresponds with the number of oocytes remaining in the ovary [8].…”

Section: Introductionmentioning

confidence: 99%

Use of anti-mullerian hormone for testing ovarian reserve: a survey of 796 infertility clinics worldwide

Tobler

Shoham

Christianson

et al. 2015

J Assist Reprod Genet

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Purpose The aim of this study is to assess how anti-mullerian hormone (AMH) is used worldwide to test ovarian reserve and guide in vitro fertilization (IVF) cycle management. Methods An internet-based survey was sent electronically to registered IVF providers within the IVF-Worldwide.com network. This survey consisted of nine questions which assessed the clinics' use of AMH. The questionnaire was completed online through the IVF-Worldwide.com website, and quality assurance tools were used to verify that only one survey was completed per clinical IVF center. Results are reported as the proportion of IVF cycles represented by a particular answer choice. Results Survey responses were completed from 796 globally distributed IVF clinics, representing 593,200 IVF cycles worldwide. Sixty percent of the respondent-IVF cycles reported to use AMH as a first line test, and 54 % reported it as the best test for evaluating ovarian reserve. Eighty-nine percent reported that AMH results were extremely relevant or relevant to clinical practice. However in contrast, for predicting live birth rate, 81 % reported age as the best predictor. Conclusions AMH is currently considered a first line test for evaluating ovarian reserve and is considered relevant to clinical practice by the majority of IVF providers.

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“…AMH is a dimeric glycoprotein produced by the granulosa cells of preantral and small antral follicles and has been noted to have strong correlation with the primordial follicle pool [13]. Since AFC is tied to AMH level and vice versa, a number of studies have compared AFC with AMH level as predictors of ovarian response in IVF.…”

Section: Discussionmentioning

confidence: 99%

Measurement of antral follicle count in patients undergoing in vitro fertilization treatment: results of a worldwide web-based survey

Christianson

Shoham

Tobler

et al. 2015

J Assist Reprod Genet

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Purpose The purpose of the present study was to identify trends in the therapeutic approaches used to measure antral follicle count (AFC) in patients undergoing in vitro fertilization (IVF) treatment worldwide. Methods A retrospective evaluation utilizing the results of a web-based survey, IVF-Worldwide (www.IVF-Worldwide. com), was performed. Results Responses from 796 centers representing 593,200 cycles were evaluated. The majority of respondents (71.2 %) considered antral follicle count as a mandatory part of their practice with most (69.0 %) measuring AFC in the follicular phase. Most respondents (89.7 %) reported that they would modify the IVF stimulation protocol based on the AFC. There was considerable variation regarding a limit for the number of antral follicles required to initiate an IVF cycle with 46.1 % designating three antral follicles as their limit, 39.9 % selecting either four or five follicles as their limit, and 14.0 % reporting a higher cutoff criteria. With respect to antral follicle size, 61.5 % included follicles ranging between 2 and 10 mm in the AFC. When asked to identify the best predictor of ovarian hyper-response during IVF cycles, AFC was selected most frequently (49.4 %), followed by anti-Mullerian hormone level (42.7 %). Age was selected as the best predictor of ongoing pregnancy rate in 81.7 % of respondents. Conclusions While a large proportion of respondents utilized AFC as part of their daily practice and modified IVF protocol based on the measurement, the majority did not consider AFC as the best predictor of ongoing pregnancy rate.

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Correlation of ovarian reserve tests with histologically determined primordial follicle number

Cited by 471 publications

References 46 publications

A putative role for anti-Müllerian hormone (AMH) in optimising ovarian reserve expenditure

A putative role for anti-Müllerian hormone (AMH) in optimising ovarian reserve expenditure

Use of anti-mullerian hormone for testing ovarian reserve: a survey of 796 infertility clinics worldwide

Measurement of antral follicle count in patients undergoing in vitro fertilization treatment: results of a worldwide web-based survey

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