"Correlation of Nutrophil Lymphocyte Count Ratio with the Severity of Acute Pancreatitis"

Abstract

Background: Acute pancreatitis is a pancreatic inflammatory condition, with the involvement of underlying tissues and remote organ systems. Early diagnosis of severe acute pancreatitis is crucial to detect complications. The purpose of this study was to correlate the NLR values with the severity of acute pancreatitis. Materials and Methods:This study was conducted at Department of Gastroenterology, Holy Family Hospital from 01 November 2020 to 30 April 2021. It was a cross sectional study. 95 patients with diagnosis of acute pancreatitis were included. Ranson's score was calculated. Severity of acute pancreatitis was confirmed on completing ranson's score. The NLR values were calculated on first day of admission and repeated after 72 hours of admission. Data were entered and analyzed using SPSS v25.0. Independent t-test was used to determine if mean score was significantly different between two categories of severe pancreatitis as per ranson's scale. Results:The mean age of the patients in our study was 64.66±5.84 year. Out of 95 patients, 40(42.1%) were males and 55(57.9%) were females. The frequency of severe acute pancreatitis was 22.1%. In patients with mild and moderate acute pancreatitis with Ranson's score<3, the mean NLR at admission was 5.45 ±2.50. while in severe AP with Ranson's score >3, the mean NLR was 14.90 ± 4.70. The results of NLR at admission and at 72 hours of admission were significantly different in patients regarding severity of acute pancreatitis. Conclusion:NLR significantly correlated with severity of acute pancreatitis. NLR can be used as a prognostic biomarker in patients admitted to the emergency department with acute pancreatitis.