Correlation of nutritional parameters of gallbladder cancer patients

Rai, Ashish; Tewari, Mallika; Mohapatra, S C; Shukla, H. S.

doi:10.1002/jso.20539

Cited by 9 publications

(9 citation statements)

References 26 publications

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“…9 The hemoglobin levels in case and control groups in the study by Rai et al were 10.87 g/dl (+/-1.81 SD) and 11.62 g/dl (+/-1.89 SD), respectively (P < 0.001). 16 The bilirubin levels both total and direct, SGPT, SGOT and alkaline phosphatase were quite high in the present study (Table 3). Total bilirubin concentration was less than 5 mg/dl only in 3.1% of the patients and the level increased to above 16 mg/dl in 31.4% of them.…”

Section: Discussionsupporting

confidence: 49%

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Circulating Concentrations of Il-2, Il-6, TNF-Alpha and Endotoxin in Patients of Carcinoma Gall Bladder

Awasthi¹,

Kacker²

2012

Int Jour of Biomed Res

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Introduction: Gallbladder Cancer represents the most common and aggressive type among the biliary tree cancers (BTCs). Carcinoma Gallbladder has an unusual geographic distribution. The highest incidence of carcinoma of gallbladder is in Chileans, American Indians, and in parts of North India. Objective: The present study was designed to characterise the circulating concentrations of endotoxin and different inflammatory mediators in patients with Carcinoma Gall bladder. Methods and Material: One hundred twenty eight Carcinoma Gall bladder patients were included in the study. Enzyme-linked immunosorbent assay was used for determining the circulating concentrations of Interleukin-2 (IL-2), Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF-α) and Endotoxins in human serum by LAL Method. A cross sectional trial was performed Results: The mean age of the patients was 50.86±12.6 years. The mean duration of jaundice was since last 74.91±50.0 days. Fifty five percent patients had cholelithiasis association with Carcinoma Gall bladder. The mean Body Mass Index (BMI) of Carcinoma Gall bladder patients were 18.33±2.8. The mean circulating concentrations of IL-2 were 33.31±56.6 pg/ml, IL-6 were 167.16±216.4 pg/ml, TNF-α were 56.00±56.7 pg/ml and endotoxin were 0.66±0.2 EU/ml. Conclusions: Mean circulating concentrations of IL-2 and TNF-α were lower and mean circulating concentrations of IL-6 were higher than the previous studies. The mean circulating concentrations of endotoxin were within the normal limits. Which concludes that cytokines may participate in gall bladder carcinogenesis and the study provides evidence for a strong link between chronic inflammation and Carcinoma Gall bladder.

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Section: Discussionsupporting

confidence: 49%

“…15 Present study supports the study by Rai et al in which, 43% of GBC patients were malnourished with low body mass index. 16 Majority of the patients in present study were anemic (Table 3). In previous studies, Anemia was present in 86 (86.9%) patients.…”

Section: Discussionmentioning

confidence: 76%

Circulating Concentrations of Il-2, Il-6, TNF-Alpha and Endotoxin in Patients of Carcinoma Gall Bladder

Awasthi¹,

Kacker²

2012

Int Jour of Biomed Res

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“…Albumin, protein and haemoglobin are serum markers which show the nutritional status in patients with cancer [36]. All three of these markers were significantly reduced in pancreatic cancer patients with cachexia, indicating a worse nutritional status.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic cancerrelated cachexia: influence on metabolism and correlation to weight loss and pulmonary function

et al. 2009

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BackgroundDramatic weight loss is an often underestimated symptom in pancreatic cancer patients. Cachexia- defined as an unintended loss of stable weight exceeding 10% – is present in up to 80% of patients with cancer of the upper gastrointestinal tract, and has a significant influence on survival. The aim of the study was to show the multiple systemic effects of cachexia in pancreatic cancer patients, in terms of resection rate, effects on pulmonary function, amount of fat and muscle tissue, as well as changes in laboratory parameters.MethodsIn patients with pancreatic cancer, clinical appearance was documented, including the amount of weight loss. Laboratory parameters and lung-function tests were evaluated, and the thickness of muscle and fat tissue was measured with computed tomography scans. Statistical analysis, including multivariate analysis, was performed using SPSS software. Survival curves were calculated using Kaplan-Meier analysis and the log-rank test. To test for significant differences between the examined groups we used Student's t-test and the Mann-Whitney U test. Significance was defined as p < 0.05.ResultsOf 198 patients with a ductal adenocarcinoma of the pancreas, 70% were suffering from weight loss when they presented for operation, and in 40% weight loss exceeded 10% of the stable weight. In patients with cachexia, metastases were diagnosed significantly more often (47% vs. 24%, P < 0.001), leading to a significantly reduced resection rate in these patients. Patients with cachexia had significantly reduced fat tissue amounts. Hence, dramatic weight loss in a patient with pancreatic cancer may be a hint of a more progressed or more aggressive tumour.ConclusionPancreatic cancer patients with cachexia had a higher rate of more progressed tumour stages and a worse nutritional status. Furthermore, patients with cachexia had an impaired lung function and a reduction in fat tissue. Patients with pancreatic cancer and cachexia had significantly reduced survival. If weight loss exceeded 5% there was a significantly reduced resection rate to detect, but the changes were significantly more substantial if weight loss was 10% or more. We propose that a weight loss of 10% be defined as significant in pancreatic cancer.

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“…GBC presenting as gallstone ileus,[46] gallbladder perforation,[47] duodenal ulcus,[48] gastroduodenal dysmotility,[49] malnutrition,[50] venous thromboembolism,[51] gynecologic symptoms,[52] skin disorders,[53] paraneoplastic symptoms,[54] and even neuropathy[55] have been reported.…”

Section: Introductionmentioning

confidence: 99%