Correlation of nuchal translucency and thyroxine at 11–13 weeks of gestation

Hantoushzadeh, Sedigheh; Tara, Fatemeh; Salmanian, Bahram; Gharedaghi, Mohammad-Hadi; Nasri, Khadijeh; Ganjizadeh, Masoud; Ghaffari, Saeed Reza; Tahmasebpour, Ahmad‐Reza; Farrokhi, Babak; Abdollahi, Alireza; Sheikh, Mahdi; Javadian, Pouya

doi:10.3109/14767058.2013.784259

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…28 Hantoushzadeh et al showed an association between thyroxine and β-hCG, and considered that assessing hormones such as T4 may affect the interpretation of screening tests for pregnancy pathologies, especially in pregnancies with chromosomal aberrations. 29 Our study analysed a relatively small group of pregnant women. Increasing the size of the study group and the ability to assess further stages of pregnancy and the postnatal condition of the newborn would have allowed drawing broader conclusions.…”

Section: Discussionmentioning

confidence: 99%

The Levels of Pregnancy-Associated Plasma Protein (PAPP-A) and Chorionic Gonadotropin (β-hCG) in the Blood Serum of Women with Hypothyroidism in the 1st Trimester of Pregnancy

Pasińska¹,

Balcerek²,

Repczyńska³

et al. 2023

IJWH

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Introduction: Hypothyroidism occurs in pregnant women at a rate of 0.3% to 3%. The deficiency of thyroid hormones during pregnancy can lead to an increased risk of pregnancy complications and poor health of the child, particularly affecting its psychomotor development due to the intensive growth of the nervous system during gestation. The study attempted to establish the median concentrations of pregnancy-associated plasma protein PAPP-A and the free subunit of human chorionic gonadotropin β-hCG in women with hypothyroidism in the 1st trimester of pregnancy. Objective: The study attempted to establish the median concentrations of pregnancy-associated plasma protein PAPP-A and the free subunit of human chorionic gonadotropin β-hCG in women with hypothyroidism in the 1st trimester of pregnancy. Patients and methods:The study included 210 pregnant women between 11 and 13.6 weeks of pregnancy; 105 women were diagnosed with hypothyroidism before or during pregnancy, and 105 women of a similar body weight and gestational age had normal thyroid function.The measurements of the pregnancy parameters studied were performed using the DELFIA ® Xpress system. Results: Differences in the multiples of the median of the PAPP-A and β-hCG levels between women with hypothyroidism and healthy women were observed. Conclusion:Introducing correction for patients with hypothyroidism during non-invasive biochemical prenatal testing may allow obtaining more reliable results that would be the basis for referral to invasive procedures.

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Section: Discussionmentioning

confidence: 99%

The Levels of Pregnancy-Associated Plasma Protein (PAPP-A) and Chorionic Gonadotropin (β-hCG) in the Blood Serum of Women with Hypothyroidism in the 1st Trimester of Pregnancy

Pasińska¹,

Balcerek²,

Repczyńska³

et al. 2023

IJWH

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Nuchal Translucency and Congenital Heart Defects

Sofia-Gonçalves,

Guedes-Martins

2024

CCR

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Nuchal translucency comprises a temporary accumulation of fluid in the subcutaneous tissue on the back of a fetus’s neck, which accompanies the crown-rump length and is observed through an ultrasound performed between 11 and 13 weeks + 6 days gestation. Nuchal translucency is considered to be above normal when values are higher than the 95th/99th percentile or equal to or higher than 2.5/3.5 mm. The first connection between increased nuchal translucency and the presence of congenital heart defects is described in the study of Hyett et al., who observed that they are directly proportional. Since that time, several studies have been conducted to understand if nuchal translucency measurements can be used for congenital heart defect screening in euploid fetuses. However, there is great variability in the estimated nuchal translucency cutoff values for congenital heart defect detection. The purpose of this review was to understand how increased nuchal translucency values and congenital heart defects are related and to identify which of these defects are more frequently associated with an increase in these values.

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Subclinical Hypothyroidism Effect on Interpretation of Nuchal Translucency Early in Pregnancy

Fa¹,

Hamee²,

Hass³

2018

Research J. of Obstetrics and Gynecology

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Correlation of nuchal translucency and thyroxine at 11–13 weeks of gestation

Abstract: Thyroid function tests are found to independently influence NT measurements in the first trimester. Assessment of hormones such as thyroxine could optimize the interpretation of screening tests for pathological conditions during pregnancy.

Cited by 4 publications

References 28 publications

The Levels of Pregnancy-Associated Plasma Protein (PAPP-A) and Chorionic Gonadotropin (β-hCG) in the Blood Serum of Women with Hypothyroidism in the 1st Trimester of Pregnancy

The Levels of Pregnancy-Associated Plasma Protein (PAPP-A) and Chorionic Gonadotropin (β-hCG) in the Blood Serum of Women with Hypothyroidism in the 1st Trimester of Pregnancy

Nuchal Translucency and Congenital Heart Defects

Subclinical Hypothyroidism Effect on Interpretation of Nuchal Translucency Early in Pregnancy

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