Correlation of mutagenic assessment of Houston air particulate extracts in relation to lung cancer mortality rates

Walker, R. D.; Connor, Thomas H.; Macdonald, Eleanor J.; Trieff, Norman M.; Legator, Marvin S.; Mackenzie, K. W.; Dossins, J.G.

doi:10.1016/0013-9351(82)90129-3

Cited by 51 publications

(6 citation statements)

References 16 publications

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“…Differences among tlhe tests could be due to factors affecting assay efficiencies such as 1) differences in the nature of DNA lesions produced, 2:) innate differences in the bioindicator organisms, or 3) differences in test conditions. Many chemicals producing bulky lesions cause the induction of coupled SOS functions such as prophage induction and errorprone repair leading to mutagenesis: however, others produce lesions that lead exclusively to only one of the responses [Walker et al, 1982;Moreau and Devoret, 1977;Speck et al, 19781. Two nitroaromatic compounds, for example, detected in the Ames test did not induce prophage in a system used by Ma.mber and colleagues [ 19841, and the detection limits for .BaP were about an order of magnitude lower.…”

Section: Discussionmentioning

confidence: 99%

Comparative study of the mutagenic and genotoxic activity associated with inhalable particulate matter in Rio de Janeiro air

Miguel

Daisey

Sousa

1990

Environ and Mol Mutagen

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We have determined the genotoxic and mutagenic activities associated with inhalable particulate matter (IPM) collected in Rio de Janeiro, Brazil, Camden, NJ, and Caldecott Tunnel, CA, and used these results to compare three different bioassays. Samples collected every 12 hr (Rio) or every 24 hr (Camden) were extracted sequentially with cyclohexane (CX), dichloromethane (DCM), and acetone (ACE), for a rough fractionation by polarity, and composites of the extracts were tested for mutagenicity using the Salmonella frame shift (TA98) and base substitution (TA100) tester strains, as well as for genotoxicity using the Rossman Microscreen bioassay based on the induction of lambda-prophage in a lysogenic Escherichia coli strain. All samples were tested without and with S9 metabolic activation. Maximum mutagenic and genotoxic activities were in the nonpolar (CX) and polar (ACE) fractions, respectively, indicating that these two assays detect different classes of compounds with different efficiencies. Oxidative aging of the Rio aerosol is indicated by a shift in activities in both tests from the less polar fractions in the day to the polar (ACE) fraction at night. The Rio TA98 mutagenic (18 rev/m3) and genotoxic (1.4 x 10(5) PFU/m3) activities were higher than those for Camden, an Eastern U.S. city, by factors of 1.4 and 2.8, respectively.

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Section: Discussionmentioning

confidence: 99%

Comparative study of the mutagenic and genotoxic activity associated with inhalable particulate matter in Rio de Janeiro air

Miguel

Daisey

Sousa

1990

Environ and Mol Mutagen

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“…There is to date no epidemiological evidence that any harm has resulted to operating room personnel from inhaled cantery smoke [4]. A correlation between the bacterial mutagenicity level of airborne particles and lung cancer in other settings, however, has been demonstrated [4,9]. Although the health hazard risk is yet to be determined, the National Institute of Occupational Safety and Health (NIOSH) has recommended reduction in electrocautery smoke exposure by operating room personnel to minimize potential deleterious effects [ 1].…”

Section: Discussionmentioning

confidence: 99%

Laser smoke evacuator: Effective removal of mutagenic cautery smoke

Hunter

1996

Aesth. Plast. Surg.

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Electrocautery knife smoke is mutagenic, unpleasant, and possibly a health hazard to operating room personnel. Traditional smoke removal methods have been largely ineffective during procedures that generate significant smoke with electrocautery use. A commercial laser smoke evacuation and filtration unit, available in most hospital operating rooms today, has proven highly effective in rapidly eliminating essentially all visible electrocautery knife smoke and odor during breast reductions and other "high smoke" procedures.

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“…It has been well recognized that environmental airborne pollutants contain toxic components that are known or suspected to cause serious human health problems [1][2][3][4][5][6]. Many studies indicate that aerosols in the ambient 218 YUH-SHEN WU AND GUOR-CHENG FANG atmosphere may have mutagenic properties.…”

Section: Introductionmentioning

confidence: 99%

Mutagenicity and pah‐analysis of airborne particulate matter in rural site of central Taiwan, Sha‐Lu

Fang

2001

Toxicological & Environmental Chemistry

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The mutagens or carcinogens were detected in air pollutants from several sources, including combustion products such as diesel exhaust, coal, terchimney soot, fly ash, photocopier toners, cigarette smoke, and other environmental samples. Air Particulate samples for total suspended particle (TSP) was collected from August to December 1999 at Hungkuang Institute of Technology (HKIT) site in central Taiwan, Sha-Lu. Their mutagenicity was examined with Salmonella Typhimurium TA98 and TA100 in presence or absence of S9 mix. The mutagenicity showed a good correlation with amounts of the acetone extractable matter of airborne particulates. The carcinogenic polycyclic aromatic hydrocarbons (PAHs) in the airborne particulates were extracted by an organic solvent and determined by High Performance Liquid Chromatography with photodiode array detection (HPLC/PDA). The results indicated that the amounts of acetone extractable matters of air samples showed a significant correlation with direct (r = .87) and indirect mutagenicity (r = .80) in strain TA98 and with direct (r = .73) and indirect mutagenicity (r = .91) in TA100, respectively. In addition, the mutagenic activities were increased significantly during period of November to December in the rural site of central Taiwan, Sha-Lu.

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Correlation of mutagenic assessment of Houston air particulate extracts in relation to lung cancer mortality rates

Cited by 51 publications

References 16 publications

Comparative study of the mutagenic and genotoxic activity associated with inhalable particulate matter in Rio de Janeiro air

Comparative study of the mutagenic and genotoxic activity associated with inhalable particulate matter in Rio de Janeiro air

Laser smoke evacuator: Effective removal of mutagenic cautery smoke

Mutagenicity and pah‐analysis of airborne particulate matter in rural site of central Taiwan, Sha‐Lu

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