Correlation of mucocutaneous manifestations of HIV/AIDS infection with CD4 counts and disease progression

Nnoruka, Edith N.; Chukwuka, J C; Anisuiba, Ben

doi:10.1111/j.1365-4632.2007.03349.x

Cited by 64 publications

(83 citation statements)

References 14 publications

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“…Furthermore, Schechtman et al 23 demonstrated that there was a trend between numbers of Malassezia yeasts present on lesional skin, severity of seborrheic dermatitis and CD4 + T cell counts in HIV-positive patients. Nnoruko et al 24 showed that seborrheic dermatitis had occurred at CD4 + T cell counts of > 200 cells/ mm 3 in HIV/AIDS patients. The variability of data obtained in several studies could be explained by the differences in sampling sampling techniques, media culture race or region.…”

Section: Discussionmentioning

confidence: 99%

Low CD4+ T cell counts are not risk factor for Malassezia species infection in HIV/AIDS patients

Panjaitan¹,

Pudjiati

Siswati

2014

JMedScie

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Human immunodefiiency virus (HIV) infection and aquired immunodeficiency syndrome (AIDS)cause a progressive depletion of CD4 + T cell populations accompanied by progressive impairment of cellular immunity and increasing susceptibility to opportunistic infections. Seborrheic dermatitis is one of the most common skin opportunistic infections on HIV/AIDS patients. Malassezia species is bilieved as the causative of seborrheic dermatitis. The aim of the study was to evaluate low CD4 + T cell counts as risk factor for Malassezia sp. infection in HIV/AIDS patients. This was an observational study with cross-sectional design conducted on HIV/AIDS patients who attended in Department of Dermatology and Venereology, Faculty of Medicine Universitas Gadjah Mada/ Dr Sardjito General Hospital, Yogyakarta and met the inclusion and exclusion criteria. Culture of Malassezia sp. was conducted in Department of Microbiology and classified as high (>100 CFU/ tape) and low (<100 CFU/tape) density colonies. CD4 Sci, Volume 46,No. 4, CFU/tape. Tidak ada hubungan bermakna adalah kadar sel T CD4 + dengan jumlah koloni Malassezia sp dalam penelitian ini (p=0,607; 95%CI=0,(4)(5)19; RP=0,452). Dapat disimpulkan, kadar sel T CD4 + yang rendah bukan merupakan faktor terjadinya infeksi Malassezia sp. pada penderita HIV/AIDS.

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Section: Discussionmentioning

confidence: 99%

Low CD4+ T cell counts are not risk factor for Malassezia species infection in HIV/AIDS patients

Panjaitan¹,

Pudjiati

Siswati

2014

JMedScie

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“…107 SD usually occurs in HIV-positive individuals with a CD4+ T-lymphocyte count of 200-500 and is considered an early skin manifestation of AIDS. 108 Response to antiretroviral treatment is variable and there have been conflicting reports in the literature: some investigators reported an improvement in SD with the initiation of antiretroviral treatment, while others reported aggravation. 109,110 Furthermore, there have been reports of aggravation during immune reconstitution inflammatory syndrome and reports that antiretroviral treatment does not alter the prevalence or the course of SD.…”

Section: Seborrheic Dermatitis and Hivmentioning

confidence: 98%

Dermatite seborreica

Sampaio

Mameri²,

Vargas

et al. 2011

An. Bras. Dermatol.

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Seborrheic dermatitis is a chronic relapsing erythematous scaly skin disease, the prevalence of which is around 1 to 3% of the general population in the United States. It has two incidence peaks, the first in the first three months of life and the second beginning at puberty and reaching its apex at 40 to 60 years of age. The prevalence of seborrheic dermatitis is higher in HIV-positive individuals and the condition tends to be more intense and refractory to treatment in these patients. Neurological disorders and other chronic diseases are also associated with the onset of seborrheic dermatitis. The currently accepted theory on the pathogenesis of this disease advocates that yeast of Malassezia spp., present on the skin surface of susceptible individuals, leads to a non-immunogenic irritation due to the production of unsaturated fatty acids deposited on the skin surface. This article provides a review of the literature on seborrheic dermatitis, focusing on immunogenetics, the clinical forms of the disease and its treatment. . Keywords: Dermatitis; Dermatitis, seborrheic; Eczema Resumo: A dermatite seborreica é uma doença eritêmato-escamativa de caráter crônico-recidivante que acomete entre 1 e 3% da população geral dos Estados Unidos. Possui dois picos de incidência -o primeiro, durante os três primeiros meses de vida, e o segundo, a partir da puberdade, atingindo seu ápice entre os 40 e 60 anos de idade. Os indivíduos HIV positivos têm maior prevalência da doença, que apresenta maior intensidade e tendência à refratariedade ao tratamento. Doenças neurológicas e outras doenças crônicas também estão associadas ao desenvolvimento da dermatite seborreica. Como mecanismo fisiopatogênico, reconhece-se que o fungo Malassezia sp., presente na pele de indivíduos suscetíveis, leve a uma irritação não-imunogênica a partir da produção de metabólitos à base de áci-dos graxos insaturados deixados na superfície cutânea. Este artigo faz uma revisão da literatura sobre dermatite seborreica, com ênfase nos aspectos imunogenéticos, formas clínicas e tratamento.

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“…(6)(7)(8)(9) It may be the presenting feature and a valuable clinical tool in staging and predicting progression of the disease. (10)(11)(12)(13)(14)(15) …”

Section: Introductionmentioning

confidence: 99%

Pattern of Mucocutaneous Manifestations of Hiv Infected Patients: A Retrospective Study

Swamiappan¹,

Vijayabhaskar²,

Subbaiya³

et al. 2016

jemds

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Correlation of mucocutaneous manifestations of HIV/AIDS infection with CD4 counts and disease progression

Cited by 64 publications

References 14 publications

Low CD4+ T cell counts are not risk factor for Malassezia species infection in HIV/AIDS patients

Low CD4+ T cell counts are not risk factor for Malassezia species infection in HIV/AIDS patients

Dermatite seborreica

Pattern of Mucocutaneous Manifestations of Hiv Infected Patients: A Retrospective Study

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