Correlation of MRI Visual Scales with Neuropsychological Profile in Mild Cognitive Impairment of Parkinson’s Disease

Vasconcellos, Luiz Felipe Rocha; Pereira, Joäo Santos; Adachi, Marcelo; Greca, Denise Vieira; Cruz, Manuela; Malak, Ana Lara; Charchat‐Fichman, Helenice; Spitz, Mariana

doi:10.1155/2017/7380102

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…The overall cognition profiles provided by this research suggested that higher grades of the Fazekas scale in PVWMHs were strongly associated with lower cognitive function, which was partially in line with previous findings in patients with Parkinson’s disease [ 17 , 23 ]. However, the comprehensive confounding factors in the statistical model have not been adequately accounted for.…”

Section: Discussionsupporting

confidence: 91%

“…Multiple factors including cerebrovascular diseases, albuminuria, anaemia, secondary hyperparathyroidism, electrolyte imbalance, uremic toxins, inflammation and malnutrition contributed to the cognitive dysfunction [ 24–26 ]. Though different cognitive assessment tools were used, cognitive impairment was evident in patients with WMHs [ 11 , 15 , 17 , 23 , 27 ]. On the other hand, despite the relationship between Alzheimer’s disease and the Fazekas scale [ 27 , 28 ], the recent ARIC study [ 29 ] suggested that glomerular filtration rate (GFR) and urinary albumin-creatinine ratio (UACR) were associated with structural brain damage but not the region affected by Alzheimer’s disease.…”

Section: Discussionmentioning

confidence: 99%

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Cerebral white matter burden is linked to cognitive function in patients undergoing hemodialysis

Wu,

Lin

et al. 2024

Annals of Medicine

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Introduction Chronic kidney disease is related to neurodegeneration and structural changes in the brain which might lead to cognitive decline. The Fazekas scale used for assessing white matter hyperintensities (WMHs) was associated with poor cognitive performance. Therefore, this study investigated the associations between the mini-mental status examination (MMSE), Montreal cognitive assessment (MoCA), cognitive abilities screening instrument (CASI), and Fazekas scale in patients under hemodialysis (HD). Methods The periventricular (PV) WMHs and deep WMHs (DWMHs) in brain magnetic resonance images of 59 patients under dialysis were graded using the Fazekas scale. Three cognition function tests were also performed, then multivariable ordinal regression and logistic regression were used to identify the associations between cognitive performance and the Fazekas scale. Results There were inverse associations between the three cognitive function tests across the Fazekas scale of PVWMHs ( p = .037, .006, and .008 for MMSE, MoCA, and CASI, respectively), but the associations were attenuated in the DWMHs group. In CASI, significant differences were identified in short-term memory, mental manipulation, abstract thinking, language, spatial construction, and name fluency in the PVWMHs group. However, DWMHs were only significantly correlated with abstract thinking and short-term memory. Conclusion An inverse correlation existed between the Fazekas scale, predominantly in PVWMHs, and cognition in patients undergoing HD. The PVWMHs were associated with cognitive performance assessed by MMSE, MoCA, and CASI, as well as with subdomains of CASI such as memory, language and name fluency in patients undergoing HD.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Cerebral white matter burden is linked to cognitive function in patients undergoing hemodialysis

Wu,

Lin

et al. 2024

Annals of Medicine

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“…13 GCA and WML's can also be the result of normal aging. 14 The standardized systematic scoring of brain atrophy and that of vascular changes is essential while reading the MR images of patients presenting with dementia [15][16][17] and it includes GCA-scale for Global Cortical Atrophy, Fazekas scale for white matter lesions, MTA-scale for Medial Temporal lobe Atrophy and Koedam score for Parietal Atrophy.…”

Section: Introductionmentioning

confidence: 99%

Overview of neurodegenerative disorders associated with dementia: role of MRI

Alvi¹,

Mubarak²,

Alvi³

2018

MOJGG

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Dementia is a syndrome leading to deterioration in cognitive function beyond what might be expected from normal ageing. The most common dementia syndromes include Alzheimer's disease (AD), frontotemporal lobe degeneration (FTLD) and vascular Dementia (VaD). Neuroimaging including CT and MRI have a key role in early diagnosis of neurodegenerative diseases. MRI is the corner stone modality and has superior role in detecting dementia associated abnormalities like atrophy of hippocampus, medial temporal lobe or that of parietal lobe. Vascular related changes including including white matter lesions, lacunar infarcts or strategic infarcts can also be better assessed on MRI. Early diagnosis of neurodegenerative diseases can lead to early start of therapy with improved clinical outcome.

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Neuroimaging Research on Dementia in Brazil in the Last Decade: Scientometric Analysis, Challenges, and Peculiarities

2021

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The last years have evinced a remarkable growth in neuroimaging studies around the world. All these studies have contributed to a better understanding of the cerebral outcomes of dementia, even in the earliest phases. In low- and middle-income countries, studies involving structural and functional neuroimaging are challenging due to low investments and heterogeneous populations. Outstanding the importance of diagnosing mild cognitive impairment and dementia, the purpose of this paper is to offer an overview of neuroimaging dementia research in Brazil. The review includes a brief scientometric analysis of quantitative information about the development of this field over the past 10 years. Besides, discusses some peculiarities and challenges that have limited neuroimaging dementia research in this big and heterogeneous country of Latin America. We systematically reviewed existing neuroimaging literature with Brazilian authors that presented outcomes related to a dementia syndrome, published from 2010 to 2020. Briefly, the main neuroimaging methods used were morphometrics, followed by fMRI, and DTI. The major diseases analyzed were Alzheimer's disease, mild cognitive impairment, and vascular dementia, respectively. Moreover, research activity in Brazil has been restricted almost entirely to a few centers in the Southeast region, and funding could be the main driver for publications. There was relative stability concerning the number of publications per year, the citation impact has historically been below the world average, and the author's gender inequalities are not relevant in this specific field. Neuroimaging research in Brazil is far from being developed and widespread across the country. Fortunately, increasingly collaborations with foreign partnerships contribute to the impact of Brazil's domestic research. Although the challenges, neuroimaging researches performed in the native population regarding regional peculiarities and adversities are of pivotal importance.

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Correlation of MRI Visual Scales with Neuropsychological Profile in Mild Cognitive Impairment of Parkinson’s Disease

Cited by 3 publications

References 16 publications

Cerebral white matter burden is linked to cognitive function in patients undergoing hemodialysis

Cerebral white matter burden is linked to cognitive function in patients undergoing hemodialysis

Overview of neurodegenerative disorders associated with dementia: role of MRI

Neuroimaging Research on Dementia in Brazil in the Last Decade: Scientometric Analysis, Challenges, and Peculiarities

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