Correlation of MRI-derived adipose tissue measurements and anthropometric markers with prevalent hypertension in the community

Lorbeer, Roberto; Rospleszcz, Susanne; Schlett, Christopher L.; Heber, Sophia D.; Machann, Jürgen; Thorand, Barbara; Meisinger, Christa; Heier, Margit; Peters, Annette; Bamberg, Fabian; Lieb, Wolfgang

doi:10.1097/hjh.0000000000001741

Cited by 13 publications

(14 citation statements)

References 28 publications

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“…However, whether there were sex differences in the relationship between these simple markers and hypertension together with directly measured VAT and SAT has not been examined in the Chinese population. Our findings demonstrated that WC was independently associated with an increased risk of hypertension in both sexes, which was consistent with Lorbeer et al's result indicating that WC was also the most strongly associated marker of the anthropometric marker group [7]. Furthermore, WC was also significantly associated with hypertension in women but had a borderline correlation in men when adjusted for VAT and SAT.…”

Section: Discussionsupporting

confidence: 92%

“…Indirect adiposity indices such as BMI, waist circumference (WC), and hip circumference (HC) are usually used as surrogate markers because these anthropometric measures are more correlated with direct adiposity measures such as VAT or SAT [7]. Increases in WC, HC, and BMI were also associated with higher risks of hypertension [12].…”

Section: Introductionmentioning

confidence: 99%

“…Abdominal adipose tissue is manifested in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT); both of which may confer differential metabolic risk profiles [ 5 ]. Previous studies have confirmed the positive relationship between abdominal adipose tissue and hypertension [ 6 , 7 ]; however, whether the relationships of VAT and SAT to hypertension differ by sex remains unclear. For example, one study demonstrated a positive relationship between abdominal adipose tissue and measures of cardiometabolic risk, which were stronger in women than men [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Sex differences in the association of abdominal adipose tissue and anthropometric data with untreated hypertension in a Chinese population

et al. 2020

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Background: There are inconsistent interpretations of the interrelationship of adiposity, anthropometric indices, and blood pressure (BP) in hypertensive patients. Additionally, whether these relationships differ between sexes is unknown. We aimed to elucidate the associations of adiposity indices measured using quantitative computed tomography (QCT) with BP and hypertension and to determine the effect of sex on the interrelationship of these parameters in a Chinese population. Methods: Abdominal adipose fat, including the visceral adipose tissue (VAT) area and subcutaneous adipose tissue (SAT) area, was measured by QCT in 1488 patients (514 men, 974 women). Body mass index (BMI), waist circumference (WC), hip circumference (HC), and systolic (SBP) and diastolic BP (DBP) were measured. Pearson correlation coefficients, multivariate analyses, and receiver operating characteristic (ROC) curves were used to assess the relationship and potential of adiposity indices to BP and risk of hypertension within sex groups. Results: Men had significantly greater VAT area but less SAT area than women in hypertensive group. VAT, SAT, and WC were more highly correlated with SBP in men than in women. After controlling for body weight, height, and age, VAT area and WC were positively associated with SBP (VAT: β = 0.309, p < 0.001; WC: β = 0.148, p = 0.001) and DBP (VAT: β = 0.099, p = 0.034; WC: β = 0.198, p = 0.001) in women. VAT area was positively associated with SBP (β = 0.444, p < 0.001) and DBP (β = 0.146, p = 0.021) in men. WC had a significant correlation with an increased risk of hypertension in women but a borderline association in men (p = 0.059) when adjusted for VAT area and SAT area. Conclusions: The association of abdominal adiposity with hypertension differs qualitatively by sex. WC may be an important determinant of hypertension and may be used for risk stratification for hypertension among Chinese individuals.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sex differences in the association of abdominal adipose tissue and anthropometric data with untreated hypertension in a Chinese population

et al. 2020

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“…For quantification of adipose tissue compartments, volume-interpolated 3D in/opposed-phase VIBE-Dixon sequence was performed and adipose tissues were segmented semi-automatically 28,29 . SAT was quantified from cardiac apex to femoral head and VAT was quantified from diaphragm to femoral head; Total adipose tissue was defined as the sum of SAT and VAT, all indicated in liter.…”

Section: Methodsmentioning

confidence: 99%

Association of longitudinal risk profile trajectory clusters with adipose tissue depots measured by magnetic resonance imaging

Rospleszcz

Lorbeer

Storz

et al. 2019

Sci Rep

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The objective of the study was to identify associations of longitudinal trajectories of traditional cardiometabolic risk factors with abdominal and ectopic adipose tissue depots measured by magnetic resonance imaging (MRI). We measured total abdominal, visceral, and subcutaneous adipose tissue in liter and intrahepatic, intrapancreatic and renal sinus fat as fat fractions by MRI in 325 individuals free of cardiovascular disease at Exam 3 of a population-based cohort. We related these MRI measurements at Exam 3 to longitudinal risk profile trajectory clusters, based on risk factor measurements from Exam 3, Exam 2 (seven years prior to MRI) and Exam 1 (14 years prior to MRI). Based on the levels and longitudinal trajectories of several risk factors (blood pressure, lipid profile, anthropometric measurements, HbA1c), we identified three different trajectory clusters. These clusters displayed a graded association with all adipose tissue traits after adjustment for potential confounders (e.g. visceral adipose tissue: βClusterII = 1.30 l, 95%-CI:[0.84 l;1.75 l], βClusterIII = 3.32 l[2.74 l;3.90 l]; intrahepatic: EstimateClusterII = 1.54[1.27,1.86], EstimateClusterIII = 2.48[1.93,3.16]. Associations remained statistically significant after additional adjustment for the risk factor levels at Exam 1 or Exam 3, respectively. Trajectory clusters provided additional information in explaining variation in the different fat compartments beyond risk factor profiles obtained at individual exams. In conclusion, sustained high risk factor levels and unfavorable trajectories are associated with high levels of adipose tissue; however, the association with cardiometabolic risk factors varies substantially between different ectopic adipose tissues. Trajectory clusters, covering longitudinal risk profiles, provide additional information beyond single-point risk profiles. This emphasizes the need to incorporate longitudinal information in cardiometabolic risk estimation.

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“…The isotropic VIBE-Dixon sequence was also acquired for the analysis and evaluation of abdominal adipose tissue compartments and adipose tissues were segmented semi-automatically, as described previously [14,17,18]. Thus, volumetric assessment of the subcutaneous adipose tissue (SAT) from the femoral head to the cardiac apex and visceral adipose tissue (VAT) from the femoral head to the cardiac apex was quantified by a fat selective tomogram using an in-house algorithm (based on Matlab R2013a).…”

Section: Assessment Of Adipose Tissue Compartmentsmentioning

confidence: 99%

Magnetic Resonance Imaging of Diverticular Disease and its Association with Adipose Tissue Compartments and Constitutional Risk Factors in Subjects from a Western General Population

Storz

Rospleszcz

Askani

et al. 2020

Rofo

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Purpose To determine the association of asymptomatic diverticular disease as assessed by magnetic resonance imaging (MRI) with adipose tissue compartments, hepatic steatosis and constitutional risk factors within a cohort drawn from a Western general population. Materials and Methods Asymptomatic subjects enrolled in a prospective case-control study underwent a 3 Tesla MRI scan, including an isotropic VIBE-Dixon sequence of the entire trunk. The presence and extent of diverticular disease were categorized according to the number of diverticula in each colonic segment in a blinded fashion. The amount of visceral, subcutaneous, and total adipose tissue (VAT, SAT, and TAT) was quantified by MRI. Additionally, the degree of hepatic steatosis, indicated as hepatic proton density fat fraction (hepatic PDFF) was determined using a multi-echo T1w sequence. Constitutional cardiometabolic risk factors were obtained and univariate and multivariate associations were calculated. Results A total of 371 subjects were included in the analysis (58.2 % male, 56.2 ± 9.2 years). Based on MRI, 154 participants (41.5 %) had diverticular disease with 62 cases (17 %) being advanced diverticular disease. Subjects with advanced diverticular disease had a significantly higher body mass index (BMI) (BMI: 29.9 ± 5.1 vs. 27.5 ± 4.6, p < 0.001; respectively). Furthermore, all adipose tissue compartments were increased in subjects with advanced diverticular disease (e. g. VAT: 6.0 ± 2.8 vs. 4.2 ± 2.6 and SAT: 9.2 ± 3.6 vs. 7.8 ± 3.6, all p < 0.001, respectively). Similarly, subjects with advanced diverticular disease had significantly higher hepatic PDFF (4.9 [2.7, 11.4] vs. 6.1 [5.5, 14.6], p = 0.002). Conclusion Advanced diverticular disease is associated with an increased volume of adipose tissue compartments and BMI, which may suggest a metabolic role in disease development. Key Points: Citation Format

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Correlation of MRI-derived adipose tissue measurements and anthropometric markers with prevalent hypertension in the community

Abstract: MRI-derived adipose tissue measurements perform similarly in identifying prevalent hypertension compared with anthropometric markers. Especially, TAT, VAT and PAT as well as WHtR and waist circumference were highly correlated with prevalent hypertension.

Cited by 13 publications

References 28 publications

Sex differences in the association of abdominal adipose tissue and anthropometric data with untreated hypertension in a Chinese population

Sex differences in the association of abdominal adipose tissue and anthropometric data with untreated hypertension in a Chinese population

Association of longitudinal risk profile trajectory clusters with adipose tissue depots measured by magnetic resonance imaging

Magnetic Resonance Imaging of Diverticular Disease and its Association with Adipose Tissue Compartments and Constitutional Risk Factors in Subjects from a Western General Population

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