Correlation of mitochondrial function and ischemic contracture

Jd, Sink; Currie, William D.; Gl, Pellom; Rc, Hill; Wr, Chitwood; As, Wechsler

doi:10.1016/s0022-5223(19)37922-x

Cited by 14 publications

(3 citation statements)

References 22 publications

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“…The latter has been shown to correlate with the recovery of cardiac function at reperfusion (38). In isolated rat hearts, decreased mitochondrial function and reduced ATP and creatine phosphate content were demonstrated to correlate with myocardial ischemic contracture during normothermic ischemia (40). In another isolated rat heart model, hypothermia and high-K ϩ , high-Mg 2ϩ cardioplegia together were shown to maintain a higher level of ATP and creatine phosphate in heart tissue than hypothermia alone (16).…”

Section: Discussionmentioning

confidence: 99%

Effect of estrogen on global myocardial ischemia-reperfusion injury in female rats

Zhai¹,

Eurell²,

Cotthaus³

et al. 2000

American Journal of Physiology-Heart and Circulatory Physiology

161

119

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We investigated the effects of estrogen on global myocardial ischemia-reperfusion injury in rats that were ovariectomized (Ovx), sham-operated, or ovariectomized and then given 17beta-estradiol (E(2)beta) supplementation (Ovx+E(2)beta). Hearts were excised, cannulated, perfused with and then immersed in chilled (4 degrees C) cardioplegia solution for 30 min, and then retrogradely perfused with warm (37 degrees C), oxygenated Krebs-Henseleit bicarbonate buffer for 120 min. The coronary flow rate, first derivative of left ventricular pressure, and nitrite production were all significantly lower in Ovx than in sham-operated or Ovx+E(2)beta hearts. However, coronary flow rates or nitrate production were not consistently different throughout the entire reperfusion period. Ca(2+) accumulated more in Ovx rat hearts than in sham-operated or Ovx+E(2)beta hearts, and mitochondrial respiratory function was lower in Ovx hearts than in hearts from the other two groups. Marked interstitial edema and contraction bands were seen in hematoxylin-eosin-stained sections of Ovx rat hearts but not in hearts from either of the other groups. Hematoxylin-basic fuchsin-picric acid-stained sections revealed fewer viable myocytes in hearts from the Ovx group than from the sham or Ovx+E(2)beta group. Transmission electron microscopy demonstrated more severely damaged mitochondria and ultrastructural damage to myocytes in Ovx rat hearts. Our results indicate that estrogen plays a cardioprotective role in global myocardial ischemia-reperfusion injury in female rats.

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Section: Discussionmentioning

confidence: 99%

Effect of estrogen on global myocardial ischemia-reperfusion injury in female rats

Zhai¹,

Eurell²,

Cotthaus³

et al. 2000

American Journal of Physiology-Heart and Circulatory Physiology

161

119

View full text Add to dashboard Cite

show abstract

“…Mitochondrial dysfunction during global surgical ischemia or cardiac storage for transplantation has been associated with compromised myocardial viability and impaired contractility. 1,6,11,24,25 In this regard, mito-chondrial structural and functional parameters have been used to assess the protective efficacy of cardioplegic solutions, [26][27][28][29] hypothermia, [30][31][32] and/or assist devices for hemodynamic support. 33 Here we evaluated the protective efficacy of a prototype mitochondrial potassium channel opener on isolated mitochondria by using a multiparametric approach that included measurements of ADP-stimulated respiration, membrane potential, ATP generation, adenylate kinase release, and morphologic integrity.…”

Section: Discussionmentioning

confidence: 99%

Diazoxide protects mitochondria from anoxic injury: Implications for myopreservation

Özcan

Holmuhamedov

Jahangir

et al. 2001

The Journal of Thoracic and Cardiovascular Surgery

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“…complexes and depletion of high-energy phosphates has been shown to occur earlier in neonatal hearts compared to adults. 8,13,14 Paradoxically, greater anaerobic glycolytic capacity and higher glycogen reserves have been demonstrated in the neonatal hearts and potentially this may provide an advantage over adult hearts with respect to tolerance to ischemic injury. 3,15,16 Under physiologic conditions, the myocardium of neonatal animals has a high capacity to utilize glucose, while adult myocardium utilizes primarily fatty acids as its energy source.…”

mentioning

confidence: 99%

Postnatal increase in insulin-sensitive glucose transporter expression is associated with improved recovery of postischemic myocardial function

Friehs

Cao-Danh

Stamm

et al. 2003

The Journal of Thoracic and Cardiovascular Surgery

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Insulin-regulated glucose transporter (GLUT-4) expression in the heart increased gradually after birth reaching nearly adult levels by 3 weeks of age. Corresponding with the higher amount of GLUT-4 protein, improved recovery of postischemic contractile function was seen in older hearts in association with increased anaerobic glycolytic capacity. Interventions to accelerate postnatal GLUT-4 expression may improve ischemic tolerance in the neonatal heart.

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Correlation of mitochondrial function and ischemic contracture

Cited by 14 publications

References 22 publications

Effect of estrogen on global myocardial ischemia-reperfusion injury in female rats

Effect of estrogen on global myocardial ischemia-reperfusion injury in female rats

Diazoxide protects mitochondria from anoxic injury: Implications for myopreservation

Postnatal increase in insulin-sensitive glucose transporter expression is associated with improved recovery of postischemic myocardial function

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