Correlation of microvascular density and proliferation index in undifferentiated nasopharyngeal carcinoma

Taweevisit, Mana; Keelawat, Somboon; Thorner, Paul

doi:10.2478/abm-2010-0039

Cited by 9 publications

(19 citation statements)

References 26 publications

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“…Beberapa penelitian di berbagai negara juga menunjukkan penderita KNF laki-laki lebih banyak daripada perempuan dengan rata-rata perbandingan 2-3:1. [20][21][22][23] Tipe histopatologi terbanyak adalah non keratinizing squamous cell carcinoma. Ukuran tumor primer terbanyak dijumpai pada penelitian ini adalah T4.…”

Section: Diskusiunclassified

“…Sebaiknya ketiga antigen dibandingkan pada jaringan karsinoma yang akan diperiksa sebelum menentukan jenis antigen mana yang lebih baik. Kelemahan pada penelitian ini adalah tidak dilakukan perbandingan penggunaan ketiga jenis antibodi, mengingat besarnya biaya reagen antibodi, disamping itu Taweevisit et al 23 pada penelitiannya terhadap jaringan karsinoma nasofaring menemukan bahwa CD31 adalah antibodi yang terbaik memberikan pewarnaan terhadap pembuluh darah, dan mewarnai latar belakang lebih sedikit dan tidak mewarnai selsel lain. Ini yang menjadi alasan pemilihan CD31 pada penelitian ini.…”

Section: Diskusiunclassified

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Korelasi positif ekspresi cyclooxygenase-2 dengan microvessel density pada karsinoma nasofaring

Hasibuan

Farhat²,

Haryuna³

et al. 2014

Oto Rhino Laryn Indones

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Pendahuluan: Tumor memerlukan proses pembentukan pembuluh darah baru untuk tumbuh dan bermetastasis yang dikenal sebagai proses angiogenesis. Angiogenesis dapat dinilai secara imunohistokimia dengan Microvessel Density (MVD). Proses angiogenesis dapat dipicu oleh berbagai faktor angiogenik. Beberapa penelitian menemukan ekspresi Cyclooxygenase-2 (COX-2) meningkat pada kanker. COX-2 dapat merangsang pengeluaran faktor-faktor angiogenik. Pada penelitian ini akan dilihat apakah angiogenesis, yang dinilai dengan MVD, pada karsinoma nasofaring memiliki korelasi dengan COX-2. Tujuan: Mengetahui korelasi ekspresi COX-2 dengan MVD pada penderita karsinoma nasofaring di RSUP H. Adam Malik Medan. Metode: Penelitian ini bersifat analitik dengan studi potonglintang. Dua puluh empat sampel diperiksa secara imunohistokimia untuk ekspresi COX-2 dan MVD. Kemudian hasil dianalisa dengan uji Spearman. Hasil: Ekspresi COX-2 positif ditemukan pada 17 (70,83%) subyek dan dijumpai negatif pada 7 (29,17%). Ditemukan 17 (70,83%) jaringan karsinoma nasofaring dengan MVD tinggi dan 7 (29,17%) dengan MVD rendah. Ditemukan adanya korelasi positif sedang antara ekspresi COX-2 dengan MVD (r=0,559; p=0,005). Kesimpulan: Ditemukan ada korelasi positif sedang antara ekspresi COX-2 dan MVD pada karsinoma nasofaring. Kata kunci : Karsinoma nasofaring, Cyclooxygenase-2, Microvessel density ABSTRACTIntroduction: Tumor needs new blood vessel formation to grow and metastasize. New blood vessel formation is known as angiogenesis. Angiogenesis is determined by Microvessel Density (MVD) using immunohistochemical examination. Angiogenesis was affected by various angiogenic factors. Recent studies found elevated COX-2 expression in cancers. COX-2 can stimulate angiogenic factors. This research assessed the correlation between COX-2 and angiogenesis, determined by MVD. Purpose: To find out the correlation between COX-2 and MVD in nasopharyngeal carcinoma in H. Adam Malik Hospital. Method: This is a cross sectional analytical research. Twenty four samples was observed by immunohistochemical examination for COX-2 expression and MVD. The results then were analyzed using Spearman correlation test. Result: Positive COX-2 expression was found in 17 (70.83%) subjects and negative in 7 (29,17%) subjects. High MVD was found in 17 (70.83%) subjects and low MVD was found in 7 (29.17%) subjects. There was moderate positive correlation between COX-2 expression and MVD (r=0,559; p=0,005). Conclusion: COX-2 is moderate positively correlated with MVD in nasopharyngeal carcinoma.Keywords :Nasopharyngeal carcinoma, Microvessel density, Cyclooxygenase-2.

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Section: Diskusiunclassified

Korelasi positif ekspresi cyclooxygenase-2 dengan microvessel density pada karsinoma nasofaring

Hasibuan

Farhat²,

Haryuna³

et al. 2014

Oto Rhino Laryn Indones

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“…Several studies have shown that the p53 protein was overexpressed in many cases of NPC as detected by immunochemistry [ 19 - 21 ]. This is further supported by the work in our laboratory which showed that p53 protein was found to be accumulated in 58 NPC biopsy samples formalin-fixed, paraffin-waxed embedded tissues of Malaysian patients but the p53 gene was not mutated at the p53 mutation hot-spots Exons 5-8 [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Epstein-Barr virus Latent Membrane Protein LMP1 reduces p53 protein levels independent of the PI3K-Akt pathway

2011

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BackgroundNasopharyngeal carcinoma (NPC) is an epithelial malignancy, which commonly occurs in Southern China, Taiwan, North Africa and Southeast Asia. Nasopharyngeal carcinoma is strongly associated with Epstein-Barr virus infection. The p53 tumour suppressor protein is rarely mutated in NPC suggesting that the inactivation of p53 pathway in NPC could be due to the presence of EBV proteins. The aim of this work was to determine the effects of EBV proteins namely LMP1 and LMP2A on the expression levels of p53 protein.FindingsIn this work we found that LMP1, but not LMP2A, decreased p53 protein levels. Overexpression of LMP1 resulted in increased ubiquitination of p53 suggesting that the decreased p53 protein levels by LMP1 was due to increased degradation of the protein. The reduction of p53 protein levels was independent of the PI3K-Akt pathway.ConclusionsLMP1, but not LMP2A, reduced p53 protein levels through the increase in the polyubiquitination of p53 protein and was independent of the PI3K-Akt pathway.

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“…In this study, the comparison of subjects with male and female gender was 2.7:1 ( Table 1). Some previous studies that have been conducted both in Medan and other countries also show that male NPC sufferers outnumber women with an average ratio of 2-3:1 [17][18][19][20].…”

Section: Discussionmentioning

confidence: 99%

Association of E-Cadherin Expression to Clinical Stage of Nasopharyngeal Carcinoma

Triastuti

Asnir

Yudhistira

et al. 2019

IJNPC

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Article InfoIntroduction: Nasopharyngeal carcinoma (NPC) has a high incidence rate in southern China and Southeast Asia and a high rate of metastasis in head and neck cancer. NPC is a squamous cell carcinoma that grows from the surface of the lateral wall of the nasopharynx. E-cadherin is known as a tumor suppressor protein and the loss of this expression in tumor cells is related to epithelial-mesenchymal transition that occurs during tumor development and metastasis. Objective: To determine the relationship between E-cadherin expression and clinical stage in patients with nasopharyngeal carcinoma. Methods: An analytical study with a cross-sectional study design, the number of samples was 30 patients with NPC who underwent immunohistochemical examination on KNF paraffin block. Result: Overexpression of E-cadherin was found in T1 and T2 of 15 subjects (100%). The overexpression of Ecadherin was found in lymph node N2 and N3 of 19 subjects (95%). The overexpression of E-cadherin was found in the histopathological type of Non-Keratinizing Squamous Cell Carcinoma of 24 subjects (96%). The overexpression of E-cadherin was found at an advanced stage of 26 subjects (100%). Conclusion: No significant association was found between E-cadherin expression and tumor size (p=1.000), lymph node metastasis (p=1.000), histopathological type (p=1.000) and tumor stage (p=0.133).

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Correlation of microvascular density and proliferation index in undifferentiated nasopharyngeal carcinoma

Cited by 9 publications

References 26 publications

Korelasi positif ekspresi cyclooxygenase-2 dengan microvessel density pada karsinoma nasofaring

Korelasi positif ekspresi cyclooxygenase-2 dengan microvessel density pada karsinoma nasofaring

Epstein-Barr virus Latent Membrane Protein LMP1 reduces p53 protein levels independent of the PI3K-Akt pathway

Association of E-Cadherin Expression to Clinical Stage of Nasopharyngeal Carcinoma

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