Correlation of MCP-4 and high-sensitivity C-reactive protein as a marker of inflammation in obesity and chronic periodontitis

Pradeep, A.R.; Kumari, Minal; Kalra, Nitish; Priyanka, N

doi:10.1016/j.cyto.2012.12.022

Cited by 22 publications

(29 citation statements)

References 42 publications

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“…Although detailed mechanism of up-regulation in serum from CRC patients with distant metastasis still remains unclear field, several evidences suggest the clue of up-regulation mechanism of serum MCP-4 in metastatic CRC patients. As first, previous studies demonstrated that serum MCP-4 levels were significantly correlated with systemic inflammatory response and serum CRP levels in other type of inflammatory disease [37,38]. Interestingly, our data showed that serum CRP levels were significantly increased in CRC patients with distant metastasis in clinical validation cohort (P < 0.001, data not shown).…”

Section: Discussionsupporting

confidence: 61%

Elevated serum concentration of monocyte chemotactic protein 4 (MCP-4) as a novel non-invasive prognostic and predictive biomarker for detection of metastasis in colorectal cancer

et al. 2016

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Section: Discussionsupporting

confidence: 61%

Elevated serum concentration of monocyte chemotactic protein 4 (MCP-4) as a novel non-invasive prognostic and predictive biomarker for detection of metastasis in colorectal cancer

et al. 2016

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“…While inflammation is an important component of secondary brain injury throughout all phases of recovery, its biological pleiotropy makes the interpretation of the current results difficult. For example, MCP-4 is a candidate biomarker for several inflammatoryrelated health conditions such as arthritis, obesity, asthma and respiratory infection (Baumann et al, 2013;Breland et al, 2010;Gentili et al, 2016;Okugawa et al, 2016;Pradeep et al, 2013;Relster et al, 2017). Furthermore, both MCP-1 and -4 have been associated with disturbances in the neuroendocrine-immune axis in posttraumatic stress disorder (Dalgard et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Blood biomarkers are associated with brain function and blood flow following sport concussion

Battista

Churchill

Schweizer

et al. 2018

Journal of Neuroimmunology

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We identified robust relationships between peripheral blood biomarkers and MRI measures in both recently concussed athletes and healthy athletes with a history of concussion. The results from this combinatorial approach further support that human concussion is associated with inflammation, oxidative stress, and cellular damage, and that physiological perturbations may extend chronically beyond recovery. Finally, our results support the continued implementation of blood biomarkers as a tool to investigate brain injury, particularly in a multimodal framework.

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“…However, it has recently been proposed that hs-CRP may be a useful marker linking periodontal disease and chronic inflammation [76] which leads to endothelial dysfunction [69]. Periodontitis has been reported to attenuate endothelium-dependent vasodilatation in experimental rats.…”

Section: Possible Linking Pathways For the Association Between Hypmentioning

confidence: 99%

Association between Hypertension and Periodontitis: Possible Mechanisms

Leong

Baharin

et al. 2014

The Scientific World Journal

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This review is to examine the current literatures on the relationship between periodontitis and hypertension as well as to explore the possible biological pathways underlying the linkage between these health conditions. Hypertension is one of the major risk factors for cardiovascular diseases. Oxidative stress and endothelial dysfunction are among the critical components in the development of hypertension. Inflammation has received much attention recently and may contribute to a pivotal role in hypertension. Periodontitis, a chronic low-grade inflammation of gingival tissue, has been linked to endothelial dysfunction, with blood pressure elevation and increased mortality risk in hypertensive patients. Inflammatory biomarkers are increased in hypertensive patients with periodontitis. Over the years, various researches have been performed to evaluate the involvement of periodontitis in the initiation and progression of hypertension. Many cross-sectional studies documented an association between hypertension and periodontitis. However, more well-designed prospective population trials need to be carried out to ascertain the role of periodontitis in hypertension.

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Correlation of MCP-4 and high-sensitivity C-reactive protein as a marker of inflammation in obesity and chronic periodontitis

Cited by 22 publications

References 42 publications

Elevated serum concentration of monocyte chemotactic protein 4 (MCP-4) as a novel non-invasive prognostic and predictive biomarker for detection of metastasis in colorectal cancer

Elevated serum concentration of monocyte chemotactic protein 4 (MCP-4) as a novel non-invasive prognostic and predictive biomarker for detection of metastasis in colorectal cancer

Blood biomarkers are associated with brain function and blood flow following sport concussion

Association between Hypertension and Periodontitis: Possible Mechanisms

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