Correlation of matrix metalloproteinases and their inhibitors with hypoxia and angiogenesis in premenopausal patients with adenocarcinoma of the breast

Govindarajah, Vinothini; Aravindraja, Chairmandurai; Chitrathara, K; Nagini, Siddavaram

doi:10.1016/j.clinbiochem.2011.05.010

Cited by 10 publications

(10 citation statements)

References 41 publications

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“…The overexpression of VEGF in malignant breast tumor can reflect the potential of angiogenesis in the tumor tissue (Perrot-Applanat et al, 2012). The overexpression of MMP-2 indicates the damage of the integrity of microvascular basement membrane and the change of heterologous tumor vascular function (Vinothini et al, 2011). On the other hand, the low level expressions of VEGF, MMP-2 in benign tumor may have little effect on the amount of angiogenesis and vessel permeability.…”

Section: Discussionmentioning

confidence: 99%

Clinical Study of Tumor Angiogenesis and Perfusion Imaging Using Multi-slice Spiral Computed Tomography for Breast Cancer

Xu¹,

Lei²,

Li³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Objectives: To explore the correlation between multi-slice spiral CT (MSCT) perfusion parameters and the expression of vascular endothelial growth factor (VEGF) as well as matrix metalloproteinase-2 (MMP-2) in breast cancer. Methods: Forty five breast cancer patients and 16 patients with benign breast tumor, both confirmed by pathology examination, were enrolled. All underwent MSCT perfusion imaging to obtain perfusion maps and data for parameters including blood flow (BF), blood volume (BV) and permeability surface (PS). Cancer patients did not receive treatment prior to surgery. The expression of VEGF and MMP-2 were examined with both immunohistochemistry and Western blotting. Results: The levels of VEGF and MMP-2 by immunohistochemistry were significantly higher in the breast cancer group (P < 0.01) than the benign tumor group. Relative OD values from Western blotting were also higher in cancer cases (P < 0.05). Similarly, the mean MSCT perfusion parameters (BF, BV, PS) were significantly higher in the breast cancer group (P < 0.01), BF and BV positively correlating with VEGF expression (r = 0.878 and 0.809 respectively, P < 0.01); PS and VEGF and MMP-2 expression were also positively correlated (r= 0.860, 0.786 respectively, P < 0.01). Conclusion: There is a correlation between breast cancer MSCT perfusion parameters and VEGF andMMP-2 expression, which might be useful for detection of breast lesions, qualitative diagnosis of breast cancer, and evaluation of breast cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Clinical Study of Tumor Angiogenesis and Perfusion Imaging Using Multi-slice Spiral Computed Tomography for Breast Cancer

Xu¹,

Lei²,

Li³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…2e). Concentration of collagen decreases under the influence of collagenases during tumor invasion and metastasing [19], and vitamin B6 gradually disappears from the tumorous tissue [20]. For this reason, the square of maximum at 420 nm gradually decreases for 3 rd BC stage.…”

Section: The Results and Their Discussionmentioning

confidence: 99%

Fluorescent diagnostics of benign breast diseases and breast cancer

Maryakhina

Korneva

Chekurov

et al. 2017

J-BPE

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Abstract. In the study the spectra of fluorescence excitation and autofluorescence of histological sections with different pathological processes in breast were measured. Additionally, element composition of the tissues was investigated by scanning electron microscopy. It has been shown that spectra of fluorescence excitation of benign breast diseases (fibroadenoma and fibrocystic breast disease) have low maximum at 232 nm and high maximum at 260 nm. Also, fluorescence spectra of histological samples change during tumor growth and have two maxima (335 and 420 nm). The registered spectra are result of emission of such fluorophores as fatty acids, tryptophan, NADH, vitamin B6, collagen and bilirubin. The obtained spectral data correlate well with data of element analysis. Selenium status of the tissues was investigated by scanning electronic microscope. High concentration if selenium was detected only in fibroadenoma. In breast cancer samples and fibrocystic breast disease low selenium content was detected. It may confirm higher risk for malignant transformation of fibrocystic breast disease than fibroadenoma. Our results may be helpful for cancer diagnostics and for prognosis prediction.

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“…Other studies on the association between MMP-2 levels and clinicopathologic factors were not inconsistent. While several studies reported that higher serum levels of MMP-2 were shown in the patients with more advanced tumor stage (26,28,33,34), the others showed lower MMP-2 levels in patients with many poor prognostic factors including advanced tumor stage or grade (27,29,35).…”

Section: Discussionmentioning

confidence: 99%

“…[19][20][21][22][23], whereas few others have suggested inconsistent results (24,25). Although there were several studies on the association between the levels of serum MMP-2 and clinicopathologic factors, the results were inconsistent across the studies (26)(27)(28)(29)(30)(31)(32)(33)(34)(35). So far, only a few studies have investigated the association between MMP-2 levels and breast cancer prognosis (36,37).…”

Section: Introductionmentioning

confidence: 99%

Preoperative Serum Levels of Matrix Metalloproteinase-2 (MMP-2) and Survival of Breast Cancer among Korean Women

Song

Sung

Choi

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Matrix metalloproteinase-2 (MMP-2) has been thought of as a predictor of recurrence or metastasis risk or prognostic markers in cancer. We evaluated whether preoperative serum levels of MMP-2 work as a prognostic biomarker in breast cancer prognosis.Methods: Preoperative serum levels of MMP-2 were measured with ELISA in 303 patients with histologically confirmed breast cancer. The median follow-up time for all patients was 4.24 years. The relationship of MMP-2 to survival was investigated using Cox proportional hazard regression model adjusted for the tumornode-metastasis (TNM) stage and estrogen receptor (ER) status.Results: In the multivariate analysis, disease-free survival (DFS) was worse among patients with the third tertile of MMP-2 level than with the first tertile of MMP-2 level [hazard ratio, 1.80; 95% confidence interval (CI), 1.04-3.11; P ¼ 0.04]. However, when the patients were stratified by age, ER status, histologic grade, and nuclear grade, inverse correlation was shown between serum MMP-2 levels and prognostic factors, and the associations between MMP-2 and DFS were only significant among patients with poor prognostic factors (HR, 2.75; 95% CI, 1.32-5.73 in ER-negative; HR, 2.90; 95% CI, 1.42-5.92 in histologic grade III; and HR, 2.61; 95% CI, 1.26-5.39 in nuclear grade III).Conclusions: Our results suggest that the preoperative serum levels of MMP-2 were associated with the survival in patients with breast cancer in ER-negative, higher histologic grade, or higher nuclear grade breast cancers.Impact: Our results indicate that serum levels of MMP-2 may play a role as prognostic biomarker in breast cancer survival. Cancer Epidemiol Biomarkers Prev; 21(8); 1371-80. Ó2012 AACR.

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Correlation of matrix metalloproteinases and their inhibitors with hypoxia and angiogenesis in premenopausal patients with adenocarcinoma of the breast

Cited by 10 publications

References 41 publications

Clinical Study of Tumor Angiogenesis and Perfusion Imaging Using Multi-slice Spiral Computed Tomography for Breast Cancer

Clinical Study of Tumor Angiogenesis and Perfusion Imaging Using Multi-slice Spiral Computed Tomography for Breast Cancer

Fluorescent diagnostics of benign breast diseases and breast cancer

Preoperative Serum Levels of Matrix Metalloproteinase-2 (MMP-2) and Survival of Breast Cancer among Korean Women

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