Correlation of Matrix Metalloproteinase-9 (MMP-9) expression and bone destruction in Chronic Suppurative Otitis Media (CSOM) patients with cholesteatoma  at Adam Malik General Hospital Medan-Indonesia

Yulius, S.; Asroel, Harry Agustaf; Aboet, Askaroellah; Zaluchu, Fotarisman

doi:10.15562/bmj.v7i1.751

Cited by 6 publications

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“…Furthermore, based on the research results of Islam et al (2010), in Bangladesh, the most complications were intratemporal complications, namely mastoid abscess as many as 11 people (50%) [16]. Following the study of Yulius et al, 2018, 87.5% of patients with otitis media with cholesteatoma suffered from intratemporal complications, and only 12.5% had intracranial complications [17]. In this study, the most complications were intratemporal complications, namely mastoiditis.…”

Section: Discussionmentioning

confidence: 47%

Description of Patients with Chronic Suppurative Otitis Media at H. Adam Malik Hospital Medan 2016-2018

Husni¹

2021

IJSRP

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Background: Chronic suppurative otitis media (CSOM) is a common cause of hearing loss in developing countries. CSOM is a disease with high prevalence, and if not treated properly, it can lead to various complications that lead to decreased quality of life and death. The incidence of chronic suppurative otitis media in multiple regions in Indonesia is still relatively high. It can be estimated that there are 6.6 million people with CSOM from the 220 million population of Indonesia. Objective: This study aimed to determine the characteristics of chronic suppurative otitis media patients at RSUP H. Adam Malik Medan from January 2016 to December 2018. Method: This study was a retrospective descriptive study using 188 medical records of patients diagnosed primarily with chronic suppurative otitis media at H. Adam Malik General Hospital Medan from January 2016 to December 2018. Results: From 188 patients with CSOM, 69 patients (36.7%) were in the 17-25 year age group. Most sufferers were male, about 125 patients (66.5%). Based on the level of education, the highest proportion was in primary school, with about 55 patients (29.3%). Based on the occupation, the highest proportion did not work as much, 62 patients (33%). The main complaint was ear discharges of about 109 patients (58%). The most common type of perforation was a central perforation, about 72 patients (38.3%). The highest proportion by type was a benign type of CSOM, about 112 patients (59.6%). Mastoiditis complications were the most common complications, about 98 patients (52.1%). The highest proportion of therapy with drugs was 83 patients (44.2%). The highest culture was 149 patients (79.2%) with Pseudomonas aeruginosa as a result.

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Section: Discussionmentioning

confidence: 47%

Description of Patients with Chronic Suppurative Otitis Media at H. Adam Malik Hospital Medan 2016-2018

Husni¹

2021

IJSRP

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“…The criteria for a successful CWU tympanoplasty are an intact graft 12 months post-surgery with excellent integrity; post-surgery examination showing a good healing process with no effusion, atelectasis or otorrhea; and stable or improved hearing with a minimum hearing threshold escalation of 10.0 dB. 18,19 In our study, 52.7% of patients experienced a more-than-10.0-dB improvement in hearing threshold. The mean of air conduction threshold improvement over the two years investigated in our study was 10.9 dB.…”

Section: Discussionmentioning

confidence: 48%

“…Moderate to-severe hearing loss is found chiefly in dangerous type CSOM. 19 The degree of hearing loss is determined by the tympanic membrane perforation size, ossicular damage, and the existence of granulation tissue or cholesteatoma. 5 The more extensive the perforation, the smaller the surface area that can act as a sound energy conductor.…”

Section: Discussionmentioning

confidence: 99%

Hearing Evaluation Post Canal Wall-Up (CWU) Tympanoplasty on Patients with Safe Type Chronic Suppurative Otitis Media

Vidiyanti¹,

Ahadiah

Moon

2022

J Health Sci Med Res

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Objective: Otitis media is a contagious inflammatory illness of the middle ear that might have a sudden onset and a complete resolution, or it can have a persistent presentation and long-term implications. Surgical treatment is available for all kinds of otitis media. Different types of operations include canal wall-up, canal wall-down, and their variations. The wall-up approach of the two canals with or without posterior tympanotomies, also known as tympanoplasty surgery, preserves the rear wall of the ear canal. Material and Methods: Hearing evaluation was conducted after canal wall-up tympanoplasty surgery at the outpatient clinic, Department of Otorhinolaryngology, Dr. Soetomo Hospital, Surabaya, Indonesia over a period of two years (2018-2019). Results: Two hundred and thirty-seven patients underwent from January 1, 2018 to December 31, 2019. However, only 74 (31.2%) of them had complete medical records after surgery. Fifty-nine ears (79.7%) experienced a better hearing threshold, six ears (8.1%) did not improve, and nine ears (12.2%) deteriorated. The hearing threshold improvement was of a magnitude of 10.9 dB; before surgery, it was 56.6 dB, and after surgery, it became 45.6 dB. Conclusion: A 10.9-dB improvement in hearing threshold mean was observed among patients undergoing canal wall-up tympanoplasty, whereas the bone gap improvement between pre- and post-tympanoplasty was 6.9 dB.

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“…Otits Media Supuratif Kronis (OMSK) adalah inflamasi kronis mukosa telinga tengah dan mastoid ditandai perforasi membran timpani disertai otore purulent yang menetap lebih dari 6 minggu meskipun dengan pemberian terapi yang adekuat terhadap otitis media akut. 1 Prevalensi OMSK bervariasi di berbagai negara, namun paling banyak ditemukan pada anak-anak di negara dengan tingkat sosial ekonomi menengah kebawah. 2 Penelitian yang dilakukan pada anak usia sekolah di Indonesia didapatkan bahwa kasus OMSK lebih tinggi di daerah pedesaan (2,7%) daripada di daerah perkotaan (0,7%).…”

Section: Pendahuluanunclassified

Potensi antibakteri tetes telinga ekstrak daun Anredera Cordifolia terhadap Pseudomonas aeruginosa penyebab Otitis Media Supuratif Kronis (OMSK)

Pranitasari

Setiawan

Lesmana

2022

Intisari Sains Medis

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Background: Chronic Suppurative Otitis Media (CSOM) is a chronic inflammation of the middle ear and mastoid mucosa characterized by perforation of the tympanic membrane and persistent discharge from the middle ear. The high resistance rate to CSOM pathogen brings hope for the development of natural-based drugs. The Binahong plant (Anredera cordifolia) has been known for a long time and is widely used as a traditional herb by Indonesian people. Flavonoid, saponins and alkaloids compounds from Binahong leaf extracts in several studies reveal its antibacterial activity. This study aims to determine the antibacterial activity of Binahong leaf extract ear drops against Pseudomonas aeruginosa, CSOM pathogen in-vitro. Methods: This is an experimental study with a post-test only control group design by testing antibacterial activity of binahong leaf extract at 1%, 3% and 5% concentrations into Pseudomonas aeruginosa American Type Culture Collection (ATCC) 9027. Chloramphenicol 1% was used as a positive control and ethanol 96% as a negative control. Data were analyzed using SPSS version 20 for Windows. Results: The minimum Inhibitory Zone Diameter (IZD) in the treatment groups A1, A2, A3 and A4 was the same, namely 0.00 mm and the maximum IZD in the treatment groups A1, A2, A3, A4 was also the same, which was 0.00 mm, so that the average IZD of the treatment groups A1, A2, A3, A4 was 0.00 mm. Meanwhile, in the A4 treatment group, the minimum IZD was 11.00 mm and the maximum IZD was 12.00 mm, so the average IZD was 11.20 mm. Conclusion: Antibacterial activity of the Binahong (Anredera cordifolia) leaf extract ear drops at 1%, 3% and 5% concentrations showed weak inhibitory response to Pseudomonas aeruginosa bacteria. Latar Belakang: Otitis media supuratif kronis (OMSK) adalah inflamasi kronis mukosa telinga tengah dan mastoid ditandai perforasi membran timpani dan keluarnya cairan dari telinga tengah yang menetap. Tingginya angka resistensi terhadap bakteri penyebab OMSK membawa harapan bagi pengembangan obat yang berbahan dasar alam. Tanaman Binahong (Anredera cordifolia) telah dikenal sejak dahulu dan banyak digunakan sebagai tanaman obat oleh masyarakat di Indonesia. Senyawa flavonoid, saponin dan alkaloid yang terkandung pada daun Binohong diketahui memiliki aktifitas antibakteri. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri tetes telinga ekstrak daun Binahong terhadap Pseudomonas aeruginosa penyebab OMSK secara in-vitro. Metode: Penelitian ini merupakan penelitian eksperimental dengan rancangan post-test only control group design yaitu menguji aktivitas antibakteri berupa diameter daerah hambat (DDH) sediaan tetes telinga ekstrak daun Binahong konsentrasi 1%, 3% dan 5% terhadap Pseudomonas aeruginosa ATCC-9027. Sebagai kontrol positif digunakan Chloramphenicol 1% dan sebagai kontrol negatif digunakan ethanol 96% Data dianalisis menggunakan SPSS versi 20 untuk Windows. Hasil: Diameter daerah hambat (DDH) minimal pada kelompok perlakuan A1, A2, A3 dan A4 adalah sama, yaitu 0,00 mm dan DDH maksimal pada kelompok perlakuan A1, A2, A3, A4 juga sama, yaitu sebesar 0,00 mm, sehingga rerata diameter daerah hambat kelompok perlakuan A1, A2, A3, A4 adalah 0,00 mm. Sedangkan pada kelompok perlakuan A4, DDH minimal adalah 11,00 mm dan DDH maksimal sebesar 12,00 mm, sehingga rerata DDH adalah 11,20 mm. Kesimpulan: Aktivitas antibakteri sediaan tetes telinga ekstrak daun Binahong (Anredera cordifolia) pada konsentrasi 1%, 3% dan 5% menunjukkan respon hambat lemah terhadap pertumbuhan bakteri Pseudomonas aeruginosa.

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Correlation of Matrix Metalloproteinase-9 (MMP-9) expression and bone destruction in Chronic Suppurative Otitis Media (CSOM) patients with cholesteatoma at Adam Malik General Hospital Medan-Indonesia

Cited by 6 publications

References 0 publications

Description of Patients with Chronic Suppurative Otitis Media at H. Adam Malik Hospital Medan 2016-2018

Description of Patients with Chronic Suppurative Otitis Media at H. Adam Malik Hospital Medan 2016-2018

Hearing Evaluation Post Canal Wall-Up (CWU) Tympanoplasty on Patients with Safe Type Chronic Suppurative Otitis Media

Potensi antibakteri tetes telinga ekstrak daun Anredera Cordifolia terhadap Pseudomonas aeruginosa penyebab Otitis Media Supuratif Kronis (OMSK)

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