Correlation of Mammographic Calcifications with HER-2/neu Overexpression in Primary Breast Carcinomas

Wang, X.; Lan, Chao; Chen, L.; Tian, Bin; Ma, Guansheng; Zang, Y.; Mao, Hua; Sun, Jingyu

doi:10.1007/s10278-008-9105-4

Cited by 22 publications

(15 citation statements)

References 14 publications

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“…Up to 50 % of all non-palpable breast cancers are detected solely through microcalcifications observed in mammogram scans whereas up to 93 % of cases of ductal carcinoma in situ (DCIS) present microcalcifications [ 3 ]. Studies have shown that breast cancers presenting with microcalcifications are more often associated with lymph node invasion [ 4 ] and HER-2 positivity [ 5 , 6 ], which results in a poorer prognosis.…”

Section: Introductionmentioning

confidence: 99%

Oxalate induces breast cancer

et al. 2015

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BackgroundMicrocalcifications can be the early and only presenting sign of breast cancer. One shared characteristic of breast cancer is the appearance of mammographic mammary microcalcifications that can routinely be used to detect breast cancer in its initial stages, which is of key importance due to the possibility that early detection allows the application of more conservative therapies for a better patient outcome. The mechanism by which mammary microcalcifications are formed is still largely unknown but breast cancers presenting microcalcifications are more often associated with a poorer prognosis.MethodsWe combined Capillary Electrochromatography, histology, and gene expression (qRT-PCR) to analyze patient-matched normal breast tissue vs. breast tumor. Potential carcinogenicity of oxalate was tested by its inoculation into mice. All data were subjected to statistical analysis.ResultsTo study the biological significance of oxalates within the breast tumor microenvironment, we measured oxalate concentration in both human breast tumor tissues and adjoining non-pathological breast tissues. We found that all tested breast tumor tissues contain a higher concentration of oxalates than their counterpart non-pathological breast tissue. Moreover, it was established that oxalate induces proliferation of breast cells and stimulates the expression of a pro-tumorigenic gene c-fos. Furthermore, oxalate generates highly malignant and undifferentiated tumors when it was injected into the mammary fatpad in female mice, but not when injected into their back, indicating that oxalate does not induce cancer formation in all types of tissues. Moreover, neither human kidney-epithelial cells nor mouse fibroblast cells proliferate when are treated with oxalate.ConclusionsWe found that the chronic exposure of breast epithelial cells to oxalate promotes the transformation of breast cells from normal to tumor cells, inducing the expression of a proto-oncogen as c-fos and proliferation in breast cancer cells. Furthermore, oxalate has a carcinogenic effect when injected into the mammary fatpad in mice, generating highly malignant and undifferentiated tumors with the characteristics of fibrosarcomas of the breast. As oxalates seem to promote these differences, it is expected that a significant reduction in the incidence of breast cancer tumors could be reached if it were possible to control oxalate production or its carcinogenic activity.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-015-1747-2) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Oxalate induces breast cancer

et al. 2015

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“…Up to 50 % of all non-palpable breast cancers are detected through microcalcifications on mammography, whereas up to 93 % of cases of ductal carcinoma in situ (DCIS) present microcalcifications [1]. Breast cancers presenting with microcalcifications are more often associated with lymph node invasion and HER-2 positivity [1,2], which results in a poorer prognosis.…”

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confidence: 99%

Dystrophic Large Calcification in Breast Cancer

Ursulescu¹,

Ursaru²,

Ciobanu³

et al. 2017

Rev. Chim.

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There are well established diagnostic criteria for calcifications detected on mammography which allows the division into: benign intermediate concern and higher probability of malignancy according to the morphology. Large calcifications are usually associated with benign breast conditions. We report three cases of breast cancer with large dystrophic calcification on imaging studies (mammography, ultrasound, computed -tomography) and histopatology displayed into the tumor as well as into the tributaries lymph nodes.

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“…This might also lead to prediction of individuals who will be responsive to a specifi c therapeutic regimen. Our initial observation showed that mammographic calcifi cations were associated with HER2/ neu expression ( 5 ). In fact, Kang et al ( 24 ) found that patients with invasive ductal carcinoma with an extensive intraductal component showed calcifi cations at mammography.…”

Section: Clinicopathologic Features Of Breast Carcinoma According To mentioning

confidence: 93%

“…Of the 170 patients, a total of 29 were excluded because of the reasons noted above. The associations of clinicopathologic features (tumor subtype, TNM stage, axillary lymph node metastasis, and tumor grade) with mammographic calcifi cations and mammographic features (mass, calcifi cation, architectural distortion, and asymmetric density) with HER2/neu overexpression in these 141 patients were evaluated in our previous study ( 5 ). Additionally, associations of OPN expression with clinicopathologic features (triple-negative subtype, TNM stage, histologic subtype, and tumor grade) in 53 of these patients have been reported previously ( 13 ).…”

Section: Breast Imaging : Osteopontin Expression In Breast Carcinomamentioning

confidence: 99%