Correlation of liver dysfunction biological markers to the mood status of alcohol-dependent individuals

Liappas, Ioannis; Piperi, Christina; Malitas, Petros; Tzavellas, Elias; Liappas, A.; Boufidou, Fotini; Kalofoutis, Christos; Bagos, Pantelis G.; Rabavilas, Andreas D.; Kalofoutis, Anastasios

doi:10.1080/13651500600633287

Cited by 1 publication

(1 citation statement)

References 35 publications

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“…While it will be easy to assume that the alterations in liver enzymes are caused by hepatic toxicity induced by ADs, this is not the case, as under treatment, patients who experienced a relapse displayed lower AST levels and AST/ALT ratios at the time of relapse. This aligns with previous research indicating that individuals undergoing antidepressant therapy usually experience a decrease in alcohol intake [67], with a normalization of hepatic enzyme levels correlated with the reduction in alcohol consumption and effective depression management [68].…”

Section: Discussionsupporting

confidence: 90%

Moderate Alcohol Consumption Increases the Risk of Clinical Relapse in Male Depressed Patients Treated with Serotonin-Norepinephrine Reuptake Inhibitors

Mușat,

Militaru,

Gheorman

et al. 2024

Diagnostics

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Background: While depression can be associated with multiple comorbidities, the association between depression and liver injury significantly increases the mortality risk. The aim of this study was to evaluate if moderate alcohol intake affects the rate of clinical relapses in patients treated with antidepressants as monotherapy. Methods: We assessed, over a period of 30 months, the clinical records of 254 patients with depressive disorder, of either gender, without additional pathologies, receiving monotherapy treatment with antidepressants. Thirty-three patients with alcohol abuse, alcoholism or significant cognitive impairment were excluded. The medical and psychiatric history, medication and liver enzyme values were collected and analyzed. Results: Out of the 221 patients who met the inclusion criteria, 78 experienced relapses of depression. The rate of relapse did not correlate with the levels of liver enzymes. Alcohol consumption, as objectified based on GGT levels and the AST/ALT ratio, suggested that men had higher alcohol intake compared to women. Patients treated with serotonin-norepinephrine reuptake inhibitors (SNRIs) with elevated AST levels were approximately 9 times more likely to relapse, while the ones with elevated GGT had a 5.34 times higher risk. While GGT levels remained a marker for relapse in men with elevated GGT, ALT and not AST proved to be a better risk indicator for relapses in male patients. Conclusion: The use of SNRIs in depressed male patients with moderate alcohol intake should be carefully considered, as they might be susceptible to higher risks of relapse compared to alternative antidepressant therapies.

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Section: Discussionsupporting

confidence: 90%

Moderate Alcohol Consumption Increases the Risk of Clinical Relapse in Male Depressed Patients Treated with Serotonin-Norepinephrine Reuptake Inhibitors

Mușat,

Militaru,

Gheorman

et al. 2024

Diagnostics

View full text Add to dashboard Cite

show abstract

Correlation of liver dysfunction biological markers to the mood status of alcohol-dependent individuals

Abstract: This observation further supports a relationship between the depressogenic action of alcohol and the disordered liver function observed in alcohol-dependent individuals, with possible implications in the diagnosis and treatment of mood disorders associated to alcohol abuse.

Cited by 1 publication

References 35 publications

Moderate Alcohol Consumption Increases the Risk of Clinical Relapse in Male Depressed Patients Treated with Serotonin-Norepinephrine Reuptake Inhibitors

Moderate Alcohol Consumption Increases the Risk of Clinical Relapse in Male Depressed Patients Treated with Serotonin-Norepinephrine Reuptake Inhibitors

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