Correlation of Ki-67 Index with Volumetric Segmentation and its Value as a Prognostic Marker in Glioblastoma

Henker, Christian; Kriesen, Thomas; Schneider, Björn; Glass, Änne; Scherer, Moritz; Langner, Sönke; Erbersdobler, Andreas; Piek, Jürgen

doi:10.1016/j.wneu.2019.02.006

Cited by 22 publications

(21 citation statements)

References 26 publications

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“…To the best of our knowledge, this is the first study to find this statistical correlation. The volume of enhancing zone and total tumor volume showed no association with a high proliferation index, as shown by other authors [21,25,26].…”

Section: Discussionmentioning

confidence: 47%

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Is Edema Zone Volume Associated With Ki-67 Index in Glioblastoma Patients?

Caramanti¹,

Aprígio²,

Rocha³

et al. 2022

Cureus

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IntroductionDespite all the progress with genetic mapping and multimodal treatment, the prognosis of Glioblastoma multiforme (GBM) remains poor, with median overall survival (OS) of only 12 to 15 months. Several studies showed correlations between glioblastoma clinic and prognosis factors; however, it doesn`t occur with tumor radiological features. The purpose of this study is to determine possible correlations between the volumetric analysis of glioblastoma compartments and the proliferation index represented by Ki-67. MethodsWe performed a retrospective analysis of MRI studies of 70 patients with glioblastoma multiforme acquired up to one week before surgery. The tumor compartments were divided into enhancing zone; edema zone and tumor total zone. Each compartment was submitted to volumetric analysis using Horos Project software. A linear regression model was used to assess correlations between the ki-67 index and the volume of each compartment with a p-value of 0.05. ResultsThe male/female ratio in our study was 1.7:1, at a mean age of 60.7 ± 14.6 years. Tumor predominant location was the temporal lobe with 25% of cases and cystic morphology was present in 17%. The median of Ki-67 was 40%. The average tumor compartment volume was 40 cm 3 for the contrast-enhancing zone, 62 cm 3 for the edema zone, and 103 cm 3 for the total tumor volume. A significant association between the Ki-67 index and edema zone volume (p=0.02) was found. ConclusionVolumetric analysis of the glioblastoma edema zone by MRI allows for predicting tumor aggressiveness through correlation with the Ki-67 index.

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Section: Discussionmentioning

confidence: 47%

“…In 2000, Shimizu et al [20] work findings revealed a relevant correlation between the Ki-67 index and choline levels on MR spectroscopy images. However, their research had limitations, such as a small number of patients, image artifacts, and possible errors in spectral evaluation [20,21].…”

Section: Discussionmentioning

confidence: 99%

Is Edema Zone Volume Associated With Ki-67 Index in Glioblastoma Patients?

Caramanti¹,

Aprígio²,

Rocha³

et al. 2022

Cureus

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show abstract

“…However, their research had limitations, such as a small number of patients, image artifacts and errors in spectral evaluation. 16,17 Our study revealed a positive association between the Ki-67 index and edema zone volume in GBM. To the best of our knowledge, this is the rst study to nd this statistical correlation.…”

Section: Discussionsupporting

confidence: 48%

“…We chose Horos Project because it is an open source, easy-to-handle software and it is accurate to delimit tumor compartments. 21 In 2019, Henker, et al 17 tried to show associations between tumor compartment volume and Ki-67 index in a study with 150 glioblastoma patients, using a 3D neuronavigation software. The authors, however, did not succeed, possibly due to a variation of volume measurement methodologies and the software used.…”

Section: Discussionmentioning

confidence: 99%

“…Volume of necrosis zone and total tumor volume showed no association with a high proliferation index as shown by other authors. [17][18][19] The method for volumetric calculations in this study was quantitative, semi-automatic, which offers the advantage of manually demarcating the contours of each type of volume selected in each of the regions of interest (ROI) of an image. This allowed us to avoid deviations in lesion volume that commonly occur when a completely automatic methodology is applied.…”

Section: Discussionmentioning

confidence: 99%

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Is edema zone volume associated with Ki-67 index in glioblastoma patients?

Caramanti

Chaddad-Neto

et al. 2021

Preprint

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Purpose: Despite all the progress with genetic mapping and multimodal treatment, the prognosis of GBM remains poor, with median overall survival (OS) of only 12 to 15 months. Several studies showed correlations between clinical features and prognosis, however the same don`t occurs with radiological features. The purpose of this study is to determine possible correlations between the volumetric analysis of glioblastoma compartments and the proliferation index represented by Ki-67. Methods: We performed a retrospective analysis of MRI studies of 70 patients with glioblastoma multiforme acquired up to one week before surgery. The tumor compartments were divided in enhancing zone; edema zone and tumor total zone. Each compartment was submitted to volumetric analysis using Horos Project software. Linear regression model was used to assess correlations between ki-67 index and volume of each compartment with p value of 0,05. Results: Male/female ratio in our study was 1.7:1, at a mean age of 60.7 ± 14.6 years. Tumor predominant location was the temporal lobe with 25% of cases and cystic morphology was present in 17%. The median of Ki-67 was 40%. The average tumor compartment volume was 40.8 cm3 for contrast-enhancing zone, 62.7 cm3 for edema zone and 103.5 cm3 for total tumor volume. A significant association between Ki-67 index and edema zone volume (p=0.02). Conclusion: Volumetric analysis of the edema zone in patients with MRI scans suggestive of glioblastoma could offer the possibility of predicting tumor aggressiveness through correlation with Ki-67 index.

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Prognostic value of Ki-67 index in primary intracranial tumors of infants

Tahta

Akalan

2023

Childs Nerv Syst

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Correlation of Ki-67 Index with Volumetric Segmentation and its Value as a Prognostic Marker in Glioblastoma

Cited by 22 publications

References 26 publications

Is Edema Zone Volume Associated With Ki-67 Index in Glioblastoma Patients?

Is Edema Zone Volume Associated With Ki-67 Index in Glioblastoma Patients?

Is edema zone volume associated with Ki-67 index in glioblastoma patients?

Prognostic value of Ki-67 index in primary intracranial tumors of infants

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