Correlation of Ionized Magnesium with the Parameters of Oxidative Stress as Potential Biomarkers in Patients with Anxiety and Depression: A Pilot Study

Opanković, Ana; Milovanović, Srđan; Radosavljević, Branimir; Čavić, Milena; Zizak, I. Besu; Bukumirić, Zoran; Latas, Milan; Medić, Branislava; Vučković, Sonja; Srebro, Dragana; Vujović, Katarina Savić

doi:10.1177/15593258221116741

Cited by 3 publications

(3 citation statements)

References 47 publications

(124 reference statements)

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“…In anxious patients, malondialdehyde had a positive correlation between the parameters of oxidative stress with ionized Mg [ 78 ]. In a recent study, the authors studied a lipid oxidative stress marker (malonic dialdehyde) and showed an increase in oxidative stress and magnesium in patients with anxiety.…”

Section: Discussionmentioning

confidence: 99%

Salivary Antioxidant Capacity and Magnesium in Generalized Anxiety Disorder

et al. 2023

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Generalized anxiety disorder (GAD) is a prevalent disorder. The search for biomarkers may contribute to new knowledge about molecular pathogenesis and treatment. Since oxidative stress and micronutrient imbalance play a key role in the development of mental disorders, we aimed to study salivary antioxidant capacity and magnesium in patients with GAD in an anxiety model of solving problems with increasing complexity. The study subgroup consisted of 15 patients with GAD, and 17 healthy volunteers of the same age made up the control subgroup. Participants took a test with six levels of difficulty, which included false feedback. In this test, the participants were asked to remember the colors of balloons and react when the color changed. The reaction time, the number of correct answers, as well as biochemical parameters such as the antioxidant capacity of saliva and salivary magnesium, were assessed. There was no difference in the results of the quest between the subgroups; however, anxious participants spent more time at the moment of experimental frustration due to incorrect feedback and additional negative psycho-emotional load. Antioxidant capacity did not differ between the subgroups both before and after the experimental session. Average antioxidant capacity also did not change significantly at the endpoint of the experiment. However, the endpoint antioxidant capacity correlated negatively with the reaction time in anxious patients in the second block (where the false feedback as a frustrating factor appeared). Magnesium was initially significantly higher in the group of anxious participants and decreased at the experiment endpoint; in healthy patients, there were no changes in salivary magnesium at the endpoint. In conclusion, the compensatory potential of oxidative metabolism and magnesium in patients with GAD was spent with additional psycho-emotional stress, in contrast to healthy individuals, but it was sufficient to avoid exhaustion during experimental frustrating exposure.

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Section: Discussionmentioning

confidence: 99%

Salivary Antioxidant Capacity and Magnesium in Generalized Anxiety Disorder

et al. 2023

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“…Дефицит магния вызывает активацию NMDA-рецепторов в сочетании с открытием кальциевых каналов, что приводит к нейрональному повреждению и дисфункции, которые могут клинически выражаться не только тревогой, но и депрессией. В настоящее время Mg2+ рассматривается как потенциальный биомаркер тревоги и депрессии [17]. Дефицит Mg2+ в центральной нервной системе при стрессе приводит к дисфункции NMDA-рецепторов с последующим повреждением клеток глии и нейронов префронтальной коры, миндалины, гиппокампа и их связей с нижележащими структурами (таламусом, гипоталамусом, гипофизом, ретикулярной формацией):…”

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A visit of an anxious patient: A review

Akarachkova,

Kadyrova,

Klimov

et al. 2024

Consilium Medicum

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In the article, the authors answered the following questions: How often do anxious patients occur in clinical practice? Why do most patients with anxiety see primary care physicians rather than a psychiatrist? What complaints and manifestations help to suspect anxiety in the patient? How can a non-psychiatrist identify and diagnose anxiety? How to manage a patient with diagnosed anxiety? Short-term and long-term outcomes/prognosis.

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“…Whittle et al showed that mice fed a low Mg-containing diet (10% of the daily requirement) exhibit depression-like behavior and elevated expression of N(G), N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH1), manganese-superoxide dismutase (MnSOD), and glutamate dehydrogenase 1 (GDH1) related to oxidative stress [ 110 ]. Another study also showed that depression is associated with a decrease in magnesium concentrations in the human body, which leads to an increase in GPX associated with oxidative stress [ 111 ].…”

Section: Overdose or Deficiency Of Mineral Element Increase The Risk ...mentioning

confidence: 99%

Appropriate Macronutrients or Mineral Elements Are Beneficial to Improve Depression and Reduce the Risk of Depression

Zhengyang

Quan

et al. 2023

IJMS

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Depression is a common mental disorder that seriously affects the quality of life and leads to an increasing global suicide rate. Macro, micro, and trace elements are the main components that maintain normal physiological functions of the brain. Depression is manifested in abnormal brain functions, which are considered to be tightly related to the imbalance of elements. Elements associated with depression include glucose, fatty acids, amino acids, and mineral elements such as lithium, zinc, magnesium, copper, iron, and selenium. To explore the relationship between these elements and depression, the main literature in the last decade was mainly searched and summarized on PubMed, Google Scholar, Scopus, Web of Science, and other electronic databases with the keywords “depression, sugar, fat, protein, lithium, zinc, magnesium, copper, iron, and selenium”. These elements aggravate or alleviate depression by regulating a series of physiological processes, including the transmission of neural signals, inflammation, oxidative stress, neurogenesis, and synaptic plasticity, which thus affect the expression or activity of physiological components such as neurotransmitters, neurotrophic factors, receptors, cytokines, and ion-binding proteins in the body. For example, excessive fat intake can lead to depression, with possible mechanisms including inflammation, increased oxidative stress, reduced synaptic plasticity, and decreased expression of 5-Hydroxytryptamine (5-HT), Brain Derived Neurotrophic Factor (BDNF), Postsynaptic density protein 95(PSD-95), etc. Supplementing mineral elements, such as selenium, zinc, magnesium, or lithium as a psychotropic medication is mostly used as an auxiliary method to improve depression with other antidepressants. In general, appropriate nutritional elements are essential to treat depression and prevent the risk of depression.

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Correlation of Ionized Magnesium with the Parameters of Oxidative Stress as Potential Biomarkers in Patients with Anxiety and Depression: A Pilot Study

Cited by 3 publications

References 47 publications

Salivary Antioxidant Capacity and Magnesium in Generalized Anxiety Disorder

Salivary Antioxidant Capacity and Magnesium in Generalized Anxiety Disorder

A visit of an anxious patient: A review

Appropriate Macronutrients or Mineral Elements Are Beneficial to Improve Depression and Reduce the Risk of Depression

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