Correlation of inflammatory and cardiovascular biomarkers with pneumonia severity scores

Lacoma, Alícia; Bas, Albert; Tudela, Pere; Giménez, M.D.; Mòdol, Josep María; Pérez, Manuela Pérez; Ausina, V.; Domínguez, José; Prat‐Aymerich, Cristina

doi:10.1016/j.eimc.2013.07.006

Cited by 13 publications

(12 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study showed an increase in MR-proADM and РСТ in high-risk groups according to CURB-65. Our data are consistent with the results of other authors, who have also observed such an increase in high-risk groups Lacoma et al, 2014). Huang et al established that elevated MR-proADM levels correlate with increased severity of CAP assessed by PSI (Huang et al 2009), and Krüger, established that РСТ levels increased with the severity of CAP assessed by the modified CRB-65 score, while there was no such increase in CRP (Krüger et al, 2008).…”

Section: Discussionsupporting

confidence: 83%

Prognostic Value of Pro-Adrenomedullin, Procalcitonin and C-Reactive Protein in Community Acquired Pneumonia

Miteva

Radkov

Ivanova

et al. 2017

CBUP

View full text Add to dashboard Cite

Abstract:Introduction: Various biomarkers are used to evaluate the severity and prognosis of community acquired pneumonia (CAP). Objectives: To study and compare the prognostic value of MR-proADM, РСТ and CRP in predicting the severity and outcome of CAP. Methods: A prospective cohort study of 92 patients hospitalized with CAP in the Clinic of Pneumology and Phthisiatrics of MHAT "Saint Marina"-Varna in 2015 was conducted. The biomarkers were measured on admission. Midregional proadrenomedullin (MR-proADM) and procalcitonin (РСТ) were measured by standard ELISA, and C-reactive protein (CRP) was determined by latex-enhanced immunoturbidimetric assay. CAP severity was assessed by CURB-65. Results: Patients were on average 59.2±16.8 years of age; 68.5% of them were male. The in-hospital mortality rate was 7.6%. The three biomarkers MR-proADM, РСТ and CRP were significantly higher in non-survivors compared to survivors (0.918±0.045 ng/ml vs. 0.397±0.269ng/ml, р<0.001; 2.14±0.60ng/ml vs. 1.12±0.68ng/ml, р<0.001 and 215.12±96.39 mg/L vs.175.74±221.5mg/L, p<0.05 respectively). In patients who needed intensive care, the biomarkers were also significantly higher than those in patients treated in the general hospital unit (0.509±0.336ng/ml vs. 0.414±0.28ng/ml, р<0.05; 1.92±0.76 ng/ml vs. 1.15±0.70ng/ml, p<0.05 and 221.98±100.34 mg/L vs. 165.31±122.84 mg/L, p<0.05 resp.). MR-proADM and РСТ showed a moderate correlation with the CURB-65 (r=0.33, p<0.01 and r=0.30, p<0.05 respectively). CRP did not correlate with the CURB-65 (r=0.10, p>0.05). Conclusion: MR-proADM, РСТ and CRP were significantly higher in non-survivors and in patients treated in the intensive care unit. MR-proADM and РСТ showed a moderate correlation with the CURB-65, while the correlation coefficient for MR-proADM was higher. CRP did not correlate with the CURB-65.UDC Classification: 616-01; DOI: http://dx

show abstract

Section: Discussionsupporting

confidence: 83%

Prognostic Value of Pro-Adrenomedullin, Procalcitonin and C-Reactive Protein in Community Acquired Pneumonia

Miteva

Radkov

Ivanova

et al. 2017

CBUP

View full text Add to dashboard Cite

show abstract

“…The sensitivity of the test, for instance, ranged from 0.46 to 0.92. Two studies with low sensitivity had a low sample size [31,34], and one of them used a very high test cut-off [31]. On the other hand, the study by Huang et al also showed a low sensitivity in spite of a large sample size and establishment of the test cut-off a priori [28].…”

Section: Discussionmentioning

confidence: 91%

“…5) [3,4,29,30,34]. There was significant increase in short-term complication with elevated MR-proADM (OR Z 5.0; 95% CI: 3.86e6.49; P value < 0.001).…”

Section: Short-term Complicationsmentioning

confidence: 85%

Midregional proadrenomedullin for prognosis in community-acquired pneumonia: A systematic review

Cavallazzi

El‐Kersh

Abu-Atherah

et al. 2014

Respiratory Medicine

View full text Add to dashboard Cite

The initial prognostic assessment of patients with community-acquired pneumonia( CAP) has important clinical implications. We hypothesized that midregional proadrenomedullin(MR-proADM) is a valuable test for the prediction of outcomes in patients with CAP.Methods: We performed a systemic review of the literature and a meta-analysis to evaluate the prognostic value of MR-proADM for short and long-term mortality in patients with CAP.Results: Twelve studies were included in the systematic review. Elevated MR-proADM was associated with an increase in short-term mortality (OR Z 6.8; 95% CI: 4.65-10.13; P value < 0.001) and complications (OR = 5.0; 95% CI: 3.86-6.49; P value < 0.001). The pooled analysis of 4 studies showed an improvement in the discriminant ability by 8% (95% CI: 2%e14%)when MR-proADM was added to CURB-65/CRB-65. Studies that reported long-term prognosis indicated an increased risk of death in patients with elevated MR-proADM.Conclusion: Elevated level of MR-proADM is significantly associated with both short-term mortality and complications in patients with CAP. Studies also indicate that MR-proADM has prognostic value for prediction of long-term mortality in these patients. The addition of MR-proADM improves the discriminant ability of CURB-65/CRB-65.

show abstract

“…The included studies were published from 2006 to 2014. Ten studies [ 27 – 33 , 35 , 36 , 38 ] were published in English, and two [ 34 , 37 ] were in Spanish. All of the studies were prospective cohorts, and three [ 27 , 31 , 38 ] were multiple-center trials.…”

Section: Resultsmentioning

confidence: 99%

Prognostic value of mid-regional pro-adrenomedullin (MR-proADM) in patients with community-acquired pneumonia: a systematic review and meta-analysis

et al. 2016

View full text Add to dashboard Cite

BackgroundThe early identification of patients at risk of dying from community-acquired pneumonia (CAP) is critical for their treatment and for defining hospital resource consumption. Mid-regional pro-adrenomedullin (MR-proADM) has been extensively investigated for its prognostic value in CAP. However, the results are conflicting. The purpose of the present meta-analysis was to explore the diagnostic accuracy of MR-proADM for predicting mortality in patients suffering from CAP, particularly emergency department (ED) patients.MethodWe systematically searched the PubMed, Embase, Web of Knowledge and Cochrane databases. Studies were included if a 2 × 2 contingency table could be constructed based on both the MR-proADM level and the complications or mortality of patients diagnosed with CAP. The prognostic accuracy of MR-proADM in CAP was assessed using the bivariate meta-analysis model. We used the Q-test and I2 index to evaluate heterogeneity.ResultsMR-proADM displayed moderate diagnostic accuracy for predicting complications in CAP, with an overall area under the SROC curve (AUC) of 0.74 (95 % CI: 0.70–0.78). Eight studies with a total of 4119 patients in the emergency department (ED) were included. An elevated MR-proADM level was associated with increased risk of death from CAP (RR 6.16, 95 % CI 4.71–8.06); the I2 value was 0.0 %, and a fixed-effects model was used to pool RR. The pooled sensitivity and specificity were 0.74 (95 % CI: 0.67–0.79) and 0.73 (95 % CI: 0.70–0.77), respectively. The positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were 2.8 (95 % CI, 2.3–3.3) and 0.36 (95 % CI, 0.29–0.45), respectively. In addition, the diagnostic odds ratio (DOR) was 8 (95 % CI, 5–11), and the overall area under the SROC curve was 0.76 (95 % CI, 0.72–0.80).ConclusionsOur study has demonstrated that MR-proADM is predictive of increased complications and higher mortality rates in patients suffering from CAP. Future studies are warranted to determine the prognostic accuracy of MR-proADM in conjunction with severity scores or other biomarkers and to determine an optimal cut-off level.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-016-1566-3) contains supplementary material, which is available to authorized users.

show abstract

Correlation of inflammatory and cardiovascular biomarkers with pneumonia severity scores

Cited by 13 publications

References 43 publications

Prognostic Value of Pro-Adrenomedullin, Procalcitonin and C-Reactive Protein in Community Acquired Pneumonia

Prognostic Value of Pro-Adrenomedullin, Procalcitonin and C-Reactive Protein in Community Acquired Pneumonia

Midregional proadrenomedullin for prognosis in community-acquired pneumonia: A systematic review

Prognostic value of mid-regional pro-adrenomedullin (MR-proADM) in patients with community-acquired pneumonia: a systematic review and meta-analysis

Contact Info

Product

Resources

About