Correlation of in vitro Sulfonamide Resistance of the Gonococcus with Results of Sulfonamide Therapy

Carpenter, Charles M.; Ackerman, Helen; Winchester, Millard E.; Whittle, Jane

doi:10.2105/ajph.34.3.250

Cited by 20 publications

(9 citation statements)

References 2 publications

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“…Effective control and prevention of gonorrhea relies on prompt and effective antimicrobial therapy. However, since the introduction of antimicrobials in the 1930s, N. gonorrhoeae has progressively developed resistance to each class used for treatment, including sulfonamides, penicillins, tetracyclines, and second-generation fluoroquinolones such as ciprofloxacin [7][8][9][10]. By 2007, cephalosporin antimicrobials were the only remaining agents recommended by the CDC for empiric treatment of gonorrhea, and no new treatment options were on the horizon [10].…”

mentioning

confidence: 99%

The Efficacy and Safety of Gentamicin Plus Azithromycin and Gemifloxacin Plus Azithromycin as Treatment of Uncomplicated Gonorrhea

Kirkcaldy

Weinstock

Moore

et al. 2014

Clinical Infectious Diseases

130

106

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Gentamicin/azithromycin and gemifloxacin/azithromycin were highly effective for treatment of urogenital gonorrhea. Gastrointestinal adverse events may limit routine use. These non-cephalosporin-based regimens may be useful alternative options for patients who cannot be treated with cephalosporin antimicrobials. Additional treatment options for gonorrhea are needed. Clinical Trials Registration. NCT00926796.

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mentioning

confidence: 99%

The Efficacy and Safety of Gentamicin Plus Azithromycin and Gemifloxacin Plus Azithromycin as Treatment of Uncomplicated Gonorrhea

Kirkcaldy

Weinstock

Moore

et al. 2014

Clinical Infectious Diseases

130

106

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“…In time resistance became widespread as the more susceptible strains were eliminated and the more resistant strains were disseminated. The strains resistant in vitro could clearly be correlated with the observed clinical failures (Carpenter et al, 1944;Love & Finland, 1955). The resistance was unevenly distributed.…”

Section: Sensitivity Of the Gonococcus To Therapeutic Agentsmentioning

confidence: 80%

Treatment Problems of Gonorrhoea

Willcox¹

1961

Obstetrical & Gynecological Survey

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“…Prompt and effective antimicrobial therapy is one of the most efficacious ways to control and prevent gonorrhea. [15–19] Unfortunately, gonorrhea has progressively developed resistance to each medication, including sulfonamides, penicillins and so on. [15–16] Although cephalosporin antimicrobials, such as ceftriaxone was recommended by the Centers for Disease Control and Prevention as the only remaining agents to treat this disorder by 2007, their efficacy are still limited.…”

Section: Introductionmentioning

confidence: 99%

“…[15–19] Unfortunately, gonorrhea has progressively developed resistance to each medication, including sulfonamides, penicillins and so on. [15–16] Although cephalosporin antimicrobials, such as ceftriaxone was recommended by the Centers for Disease Control and Prevention as the only remaining agents to treat this disorder by 2007, their efficacy are still limited. [17–19] Thus, alternative therapeutic options for gonorrhea are still urgently needed.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Bazhengsan formula as an adjunctive therapy to ceftriaxone for female patients with uncomplicated gonorrhea

2019

Medicine

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Background:This pilot study aimed to investigate the feasible effectiveness and safety of Bazhengsan formula (BZSF) as an adjunctive therapy to ceftriaxone for female patients with uncomplicated gonorrhea.Methods:This pilot randomized controlled trial compared BZSF as an adjunctive therapy to ceftriaxone with ceftriaxone alone for Chinese female patients with uncomplicated gonorrhea. A total of 40 eligible patients were randomly allocated to a treatment group (received BZSF and ceftriaxone) or a control group (received ceftriaxone alone). All patients in both groups were treated for a total of 10 days. The primary outcome included bacteriological cure. It was assessed by the eradication of urogenital gonorrhea at any site cultured after taken the study medications. The secondary outcome was clinical response. For the safety assessment, adverse events were recorded during the study period.Results:After treatment, patients in both groups achieved promising effectiveness. However, no significant differences in bacteriological cure (P = .34), clinical response (P = .11), and safety were found between 2 groups.Conclusion:The findings of this study showed that BZSF as an adjunctive therapy to ceftriaxone may be not superior to the ceftriaxone alone for Chinese female patients with uncomplicated gonorrhea after 10 days treatment.

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Correlation of in vitro Sulfonamide Resistance of the Gonococcus with Results of Sulfonamide Therapy

Cited by 20 publications

References 2 publications

The Efficacy and Safety of Gentamicin Plus Azithromycin and Gemifloxacin Plus Azithromycin as Treatment of Uncomplicated Gonorrhea

The Efficacy and Safety of Gentamicin Plus Azithromycin and Gemifloxacin Plus Azithromycin as Treatment of Uncomplicated Gonorrhea

Treatment Problems of Gonorrhoea

Effectiveness of Bazhengsan formula as an adjunctive therapy to ceftriaxone for female patients with uncomplicated gonorrhea

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