Correlation of IL-6 and JAK2/STAT3 signaling pathway with prognosis of nasopharyngeal carcinoma patients

Zhuang, Mengqi; Ding, Xiaotong; Song, Weimin; Chen, Huimin; Guan, Hui; Yu, Yang; Zhang, Zicheng; Dong, Xiang Da

doi:10.18632/aging.203186

Cited by 17 publications

(15 citation statements)

References 62 publications

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“…Among them, STAT3 is most closely related to cancer, and its abnormal activation is closely related to the occurrence and development of a variety of human malignant tumors, such as leukemia, lymphoma, prostate cancer, and all kinds of head and neck tumors and gastrointestinal tumors as well as to immune tolerance in the tumor microenvironment [ 24 ]. Studies have shown that the expression level of STAT3 protein in NPC tissue is significantly higher than that in normal nasopharyngeal tissue, and its expression is positively correlated with clinical staging [ 25 ], indicating that the expression of STAT3 and STAT 3 is closely related to the occurrence and development of NPC and provides a theoretical basis for searching molecular markers of NPC. In this study, we detected STAT3 expression levels in NPC tissues from patients with NPC and nasal mucosa tissues from patients with nasopharyngitis, and the results confirmed an upregulation of STAT3 in gastric carcinoma, which is consistent with STAT3 expression in the TCGA database.…”

Section: Discussionmentioning

confidence: 99%

Relationship between miR-338-3p and Clinicopathological Parameters, Prognosis, and STAT3 mRNA Expression in Nasopharyngeal Carcinoma

Wang

Ren

Pan

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the expression of miR-338-3p in nasopharyngeal carcinoma (NPC) and its relationship with STAT3 mRNA expression as well as their relationship with clinical pathological parameters and prognosis of patients. Methods. From September 2016 to September 2018, 71 patients with NPC were selected as the NPC group, and 71 samples of NPC tissues were collected during the operation. A total of 23 patients who underwent biopsy due to chronic nasopharyngitis were selected as the control group and 23 nasopharyngeal mucosal tissues were collected. The expressions of miR-338-3p and STAT3 mRNA in nasopharyngeal tissue of two groups were detected by real-time quantitative PCR, and the relationship between the two was analyzed. To collect clinical data of NPC patients and analyze the relationship between the expressions of miR-338-3p and STAT3 in NPC tissues and clinical pathological parameters of the patients, we followed up the patients with nasopharyngeal carcinoma for three years to observe the relationship between miR-338-3p, STAT3, and the prognosis of the patients. Results. The relative expression levels of miR-338-3p in nasopharyngeal tissues of the NPC group and the control group were 0.39 ± 0.05 and 1.01 ± 0.09, respectively ( P < 0.05). The relative expression levels of STAT3 mRNA in nasopharyngeal tissues of the NPC group and the control group were 3.82 ± 0.21 and 1.04 ± 0.11, respectively ( P > 0.05). miR-338-3p was negatively correlated with the relative expression of STAT3 mRNA in nasopharyngeal carcinoma (r = 0.038, P > 0.05). The expression of miR-338-3p was related to the age of the patient, clinical TNM stage, T stage, and distant metastasis (all P < 0.05). STAT3 expression was correlated with clinical TNM stage, T stage, and distant metastasis in our patient ( P < 0.05). The expressions of miR-338-3p and STAT3 in nasopharyngeal carcinoma tissues from different gender, histological type, N stage, M stage, and degree of differentiation showed no statistical differences ( P > 0.05). The survival rate of the group with low miR-338-3p expression was significantly lower than that of the group with high miR-338-3p expression ( P > 0.05). The survival rate of patients with the high STAT3 expression group was significantly lower than that of patients with the low STAT3 expression group ( P > 0.05). Conclusion. There is a negative correlation between the low expression of miR-338-3p and the high expression of STAT3 in NPC, which are all related to the TNM stage, T stage, and prognosis of the patient.

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Section: Discussionmentioning

confidence: 99%

Relationship between miR-338-3p and Clinicopathological Parameters, Prognosis, and STAT3 mRNA Expression in Nasopharyngeal Carcinoma

Wang

Ren

Pan

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Mechanistically, multiple signaling pathways are known to be involved in the regulation EMT and metastasis of malignant cells, including the activation of NF-κB and STAT3 [ 34 , 35 ]. The activation of NF-κB and STAT3 plays important roles in promoting EMT and metastasis and is positively associated with poor prognosis of NPC [ 40 , 41 , 42 , 43 , 44 ]. Our findings here showed that recombinant adiponectin or specific adiponectin receptor agonist, AdipoRon, could block NF-κB and STAT3 activation signaling (including leptin-, IL-6- or TNF-α-induced activation of STAT3 and NF-κB) in NPC cells.…”

Section: Discussionmentioning

confidence: 99%

Adiponectin Suppresses Metastasis of Nasopharyngeal Carcinoma through Blocking the Activation of NF-κB and STAT3 Signaling

Zhang

Du²,

Xu³

et al. 2022

IJMS

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Adiponectin is an adipocytokine with anti-inflammatory and anticancer properties. Our previous study has shown that blood adiponectin levels were inversely correlated to the risk of nasopharyngeal carcinoma (NPC), and that adiponectin could directly suppress the proliferation of NPC cells. However, the effect of adiponectin on NPC metastasis remains unknown. Here, we revealed in clinical studies that serum adiponectin level was inversely correlated with tumor stage, recurrence, and metastasis in NPC patients, and that low serum adiponectin level also correlates with poor metastasis-free survival. Coculture with recombinant adiponectin suppressed the migration and invasion of NPC cells as well as epithelial–mesenchymal transition (EMT). In addition, recombinant adiponectin dampened the activation of NF-κB and STAT3 signaling pathways induced by adipocyte-derived proinflammatory factors such as leptin, IL-6, and TNF-α. Pharmacological activation of adiponectin receptor through its specific agonist, AdipoRon, largely stalled the metastasis of NPC cells. Taken together, these findings demonstrated that adiponectin could not only regulate metabolism and inhibit cancer growth, but also suppress the metastasis of NPC. Pharmacological activation of adiponectin receptor may be a promising therapeutic strategy to stall NPC metastasis and extend patients’ survival.

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“…The expression of IL-6 in NPC tissues is a risk factor for poor prognosis of NPC and is associated with lymph node metastasis. 23 The serum IL-6 level is related to treatment. A significant decrease in serum IL-6 has been observed in treated NPC patients compared to untreated NPC patients.…”

Section: Discussionmentioning

confidence: 99%

“… 24 , 25 In terms of the molecular mechanism, IL-6 promotes the proliferation, invasion, and migration of NPC cells by activating the JAK2/STAT3 signaling pathway. 23 The role of GM-CSF in different types of tumors is contradictory. Although most studies have indicated that GM-CSF stimulates tumor progression, GM-CSF also has anti-proliferative effects in certain types of tumor cell lines and stages of development.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of a Serum Panel of Inflammatory Factors in Non-Metastatic Nasopharyngeal Carcinoma Patients Undergoing Radical Radiotherapy with Adjuvant Chemotherapy

Liang¹,

Ding²,

Lu³

et al. 2022

CMAR

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Purpose To evaluate the prognostic value of interleukin (IL)-6, IL-8, granulocyte-macrophage colony-stimulating factor (GM-CSF), leukemia inhibitory factor (LIF), and macrophage migration inhibitory factor (MIF) in non-metastatic nasopharyngeal carcinoma (NPC) patients undergoing radical radiotherapy. Patients and Methods A serum panel compromising the inflammatory factors was analyzed in 372 NPC patients before and after radiotherapy. Independent prognostic factors were screened out using multivariate Cox regression analysis. A prediction model was built based on the training set data and validated using the test set data. The prognostic value of these factors was evaluated using the time-dependent receiver operating characteristic (ROC) curve and an integrated time-averaged area under the curve (AUC). Results The baseline levels of IL-6, GM-CSF, and MIF were independent factors associated with poor OS and DMFS. A predictive model base established combining the baseline levels of these factors. The AUC values for the test set were 0.9828, 0.9968, and 0.9571 at 1, 3, and 5 years, respectively, compared to 0.9978, 0.9981, and 0.9222 for the training set, respectively. The AUC values for DMFS at 1, 3, and 5-years for the training set were 0.8744, 0.8951, and 0.9358, respectively, compared to 0.9525, 0.9663, and 0.9625 for the test set, respectively. The combination of post-treatment levels of IL-6, GM-CSF, and LIF also had good predictive value for OS with an AUC value > 0.85 during follow-up. Conclusion IL-6, GM-CSF, and MIF baseline levels are powerful prognostic factors for non-metastatic NPC patients. The combination of these factors effectively predicts OS and DMFS in non-metastatic NPC patients.

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Correlation of IL-6 and JAK2/STAT3 signaling pathway with prognosis of nasopharyngeal carcinoma patients

Cited by 17 publications

References 62 publications

Relationship between miR-338-3p and Clinicopathological Parameters, Prognosis, and STAT3 mRNA Expression in Nasopharyngeal Carcinoma

Relationship between miR-338-3p and Clinicopathological Parameters, Prognosis, and STAT3 mRNA Expression in Nasopharyngeal Carcinoma

Adiponectin Suppresses Metastasis of Nasopharyngeal Carcinoma through Blocking the Activation of NF-κB and STAT3 Signaling

Prognostic Value of a Serum Panel of Inflammatory Factors in Non-Metastatic Nasopharyngeal Carcinoma Patients Undergoing Radical Radiotherapy with Adjuvant Chemotherapy

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