Correlation of Hypoxia-Inducible Factor 1α with Angiogenesis in Liver Tumors After Transcatheter Arterial Embolization in an Animal Model

Liang, Bin; Zheng, Chuan; Feng, Gan Sheng; Wu, Han; Wang, Yong; Zhao, Hui; Qian, Jun; Liang, Hui

doi:10.1007/s00270-009-9762-9

Cited by 59 publications

(43 citation statements)

References 24 publications

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“…Nevertheless, a number of groups reported the correlation between increased mRNA and increased protein expression of Hif1α that also correlated to increased vascular density. Hif1α increased levels also correlated to increased VEGF levels that, as mentioned earlier, correlate to increased vascular density (43)(44)(45)(46)(47)(48)(49)(50)(51). We also show this pattern in our gene expression research which correlates to the increased vascular density, as observed in the grafts.…”

Section: Discussionsupporting

confidence: 65%

Improved vascular organization enhances functional integration of engineered skeletal muscle grafts

Koffler

Kaufman‐Francis²,

Shandalov³

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

179

184

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Severe traumatic events such as burns, and cancer therapy, often involve a significant loss of tissue, requiring surgical reconstruction by means of autologous muscle flaps. The scant availability of quality vascularized flaps and donor site morbidity often limit their use. Engineered vascularized grafts provide an alternative for this need. This work describes a first-time analysis, of the degree of in vitro vascularization and tissue organization, required to enhance the pace and efficacy of vascularized muscle graft integration in vivo. While one-day in vitro was sufficient for graft integration, a three-week culturing period, yielding semiorganized vessel structures and muscle fibers, significantly improved grafting efficacy. Implanted vessel networks were gradually replaced by host vessels, coupled with enhanced perfusion and capillary density. Upregulation of key graft angiogenic factors suggest its active role in promoting the angiogenic response. Transition from satellite cells to mature fibers was indicated by increased gene expression, increased capillary to fiber ratio, and similar morphology to normal muscle. We suggest a “relay” approach in which extended in vitro incubation, enabling the formation of a more structured vascular bed, allows for graft-host angiogenic collaboration that promotes anastomosis and vascular integration. The enhanced angiogenic response supports enhanced muscle regeneration, maturation, and integration.

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Section: Discussionsupporting

confidence: 65%

Improved vascular organization enhances functional integration of engineered skeletal muscle grafts

Koffler

Kaufman‐Francis²,

Shandalov³

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

179

184

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“…Using New Zealand White rabbits implanted with VX2 liver tumor, Liang et al found that HIF-1 α protein is significantly overexpressed in transcatheter arterial embolization (TAE) treated liver tumors, and 10-hydroxycamptothecin (HCPT), a HIF-1 α inhibitor, is demonstrated to have an inhibitory effect on HIF-1 α expression that subsequently inhibits angiogenesis of liver tumors after TAE treatment. These results suggested that transcatheter infusion of HCPT after TAE treatment might have a better therapeutic effect against HCC [98–100]. …”

Section: Hif-1 In the Therapy Of Hccmentioning

confidence: 99%

The Role of Hypoxia Inducible Factor-1 in Hepatocellular Carcinoma

Luo

Wang

et al. 2014

BioMed Research International

125

108

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Hypoxia is a common feature of many solid tumors, including hepatocellular carcinoma (HCC). Hypoxia can promote tumor progression and induce radiation and chemotherapy resistance. As one of the major mediators of hypoxic response, hypoxia inducible factor-1 (HIF-1) has been shown to activate hypoxia-responsive genes, which are involved in multiple aspects of tumorigenesis and cancer progression, including proliferation, metabolism, angiogenesis, invasion, metastasis and therapy resistance. It has been demonstrated that a high level of HIF-1 in the HCC microenvironment leads to enhanced proliferation and survival of HCC cells. Accordingly, overexpression, of HIF-1 is associated with poor prognosis in HCC. In this review, we described the mechanism by which HIF-1 is regulated and how HIF-1 mediates the biological effects of hypoxia in tissues. We also summarized the latest findings concerning the role of HIF-1 in the development of HCC, which could shed light on new therapeutic approaches for the treatment of HCC.

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“…Growth factors released after liver ablation can cause progression of tumors outside the ablation zone (2). After transarterial embolization, tumor ischemia stimulates angiogenesis and growth of the residual viable tumor (3, 4). Embolization can also induce an anti-tumor immune response: for example, by increasing alpha-fetoprotein (AFP)-specific CD4+ T cells after embolization of hepatocellular carcinoma (HCC) (5), or by decreasing regulatory T cells (6).…”

Section: Introductionmentioning

confidence: 99%

Adjuvant Medications That Improve Survival after Locoregional Therapy

Boas

Ziv

Yarmohammadi

et al. 2017

Journal of Vascular and Interventional Radiology

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Purpose To determine if outpatient medications taken at the time of liver tumor embolization or ablation affect survival. Methods An IRB-approved retrospective review was performed of 2032 liver tumor embolization, radioembolization, and ablation procedures on 1092 patients from June 2009 to April 2016. For each patient, the following information was analyzed: pathology, hepatocellular carcinoma (HCC) stage (AJCC), neuroendocrine tumor (NET) grade, initial locoregional therapy, overall survival after initial locoregional therapy, Child Pugh score, ECOG performance status, Charlson comorbidity index, and outpatient medications taken at the time of locoregional therapy. Kaplan Meier survival curves were calculated for patients taking 29 medications or medication classes (including both prescription and non-prescription medications), which the patient was taking for reasons unrelated to their primary cancer diagnosis. Kaplan Meier curves were compared using the log-rank test. Results For HCC patients initially treated with embolization (n=304 patients), the following medications were associated with improved survival when taken at the time of embolization: beta blockers (p=0.0007), aspirin (p=0.0008) and other NSAIDs (p=0.009), proton pump inhibitors (p=0.004), and antivirals for HBV or HCV (p=0.01). For colorectal liver metastases initially treated with ablation (n=172 patients), beta blockers were associated with improved survival when taken at the time of ablation (p=0.02). For NET patients initially treated with embolization, and colorectal patients initially treated with radioembolization, there was no association between medications and survival. Conclusion Aspirin and beta blockers are associated with significantly improved survival when taken at the time of embolization for HCC. Aspirin was not associated with survival differences after locoregional therapy for NET or colorectal liver metastases, suggesting an HCC-specific effect.

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Correlation of Hypoxia-Inducible Factor 1α with Angiogenesis in Liver Tumors After Transcatheter Arterial Embolization in an Animal Model

Cited by 59 publications

References 24 publications

Improved vascular organization enhances functional integration of engineered skeletal muscle grafts

Improved vascular organization enhances functional integration of engineered skeletal muscle grafts

The Role of Hypoxia Inducible Factor-1 in Hepatocellular Carcinoma

Adjuvant Medications That Improve Survival after Locoregional Therapy

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