Correlation of hormone receptor and human epidermal growth factor Receptor-2/neu expression in breast cancer with various clinicopathologic factors

Bansal, Cherry; Sharma, Aarti; Pujani, Mukta; Sharma, Kiran; Srivastava, Amit; Singh, Udaybir

doi:10.4103/ijmpo.ijmpo_98_16

Cited by 19 publications

(20 citation statements)

References 26 publications

(59 reference statements)

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“…It was also seen that 23 cases (28.31%) were found to be triple negative breast cancers (TNBC). This was found to be in concordance with the findings of other similar studies [16,22,24] . As we know that Breast carcinoma is a heterogeneous disease with several clinical and histopathological presentations, this is due to several gene expression subtypes and molecular profiles.…”

Section: Discussionsupporting

confidence: 94%

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Study of immune histo chemical markers in breast cancer and their correlation with various clinico pathological parameters at tertiary care center in Saurashtra region

Popat¹,

Satwara²,

Panchal³

et al. 2020

Int. J. Clin. Diagn. Pathol.

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Background: Breast cancer poses a huge epidemiological burden in Saurashtra region. Breast cancer can be completely treated if diagnosed at an early stage. Hormone receptors (ER and PR) and human epidermal growth factor receptor-2 (HER-2) are the most widely used biomarkers that are used in stratifying breast cancer treatment and management. Predictive factors evaluate the likelihood of benefit from a specific treatment. ER, PR, and HER2/neu are prognostic as well as predictive factors. The present study was conducted to correlate the expression of ER, PR, and HER2/neu with each other and to various clinopathological parameters as follows: age of the patient, histological grade, tumor size, and lymph node metastasis. Material and Method: The current study was performed at a tertiary care center in Saurashtra region on Eighty One patients diagnosed with breast malignancy. We analyzed the expression of ER, PR, HER2/neu and Ki67 index by immunohistochemistry (IHC), with each other and to various clinicopathological parameters. Result: In the present study the maximum number of patients belonged to the age group 41-59 years (61.7%). The most common histological type was Invasive Ductal carcinoma of No Special Type (IDC NST) with more common involvement of left sided breast .Out of total 81 cases, majority of the cases were classified as Luminal A. Conclusion:In the present study, majority of the patients were having invasive ductal carcinoma, NST type with various patterns of expression of IHC markers. IHC is an easy and economic method for the prognostic classification of various breast cancer where molecular techniques are unavailable. This is valuable in reducing the overall burden of breast cancer in the Saurashtra region.

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Section: Discussionsupporting

confidence: 94%

“…In the present study we also found that HER2/Neu positivity (+3) was seen in 16 cases (19.75%) which was lower when compared to some studies [22,23,24] while it was higher that the study conducted by Shukla et al [16] . It was also seen that 23 cases (28.31%) were found to be triple negative breast cancers (TNBC).…”

Section: Discussionsupporting

confidence: 46%

Study of immune histo chemical markers in breast cancer and their correlation with various clinico pathological parameters at tertiary care center in Saurashtra region

Popat¹,

Satwara²,

Panchal³

et al. 2020

Int. J. Clin. Diagn. Pathol.

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“…Also Purdie et al reported that, ER-positive BC cases are more likely to be HER2-positive than PR-negative BC cases [29]. The expression of HER of 18.4% in the present study was similar to 18.5% which was reported in Brazil and lower than 40.7%, 24%, 23.1% and 22% that were reported in India, Ghana, Tanzania and Uganda [11,15,17,28]. Studies have shown that, expression of HER in both African American and African patients with BC is higher compared to Caucasians.…”

Section: Discussionsupporting

confidence: 72%

Hormonal Receptors, Human Epidermal Growth Factor Receptor-2 and Triple Negative Immunohistochemical Typing of Women Breast Cancer in Kampala, Uganda.

Mlole

Yahaya

Othieno

et al. 2020

Preprint

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Background: The expression of estrogen and progesterone receptors and human epidermal growth factor receptor-2 has been reported to have invaluable prognostic role. This study aimed at determining the expression ER, PR and HER2 in women with breast cancer in Kampala, Uganda.Methods: Expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2) was determined immunohistochemically. Logistic regression was performed to determine the effect of the independent factors in predicting the risk of not expressing the breast markers. A two-tailed p<0.05 was regarded to be statistically significant.Results: ER, PR and HER2 were expressed in 53.4%, 46.6% and 18.5%, respectively. Co-expression of ER and PR and triple negative breast cancer was present in 42.7% and 37.9%, respectively. Age was an independent predictor of expression of ER (AOR = 0.18, 95% CI: 0.062-0.541, p = 0.002), PR (AOR = 0.35, 95% CI: 0.129-0.968, p = 0.043).Conclusion: Majority of patients in this study had less than 50 years and the majority of them had infiltrating ductal carcinoma of no special type with grade 2. Age predicted independently the expression of both ER and PR in our study.

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“…In the present study, the majority of breast cancer cases were hormone-dependent. A recent study conducted in India shows that 42.8% were oestrogen receptor-positive tumours and 31.8% were PR-positive [22]. Clearly, oestrogen is a carcinogen hormone.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological profile and distribution of prognostic factors in invasive breast cancer among Algerian women

2021

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Although the widespread of early screening and advanced medical therapies, the breast cancer incidence rate continues to rise among Algerian women. This retrospective study investigated mammary lesions’ epidemiological profile and histopathological characteristics and evaluated primary invasive breast cancer prognostic factors. We found that the incidence of breast cancer increases in middle- aged women between 40 and 60 years. Scarff Bloom Richardson grade II predominates in invasive breast cancer samples. In this study, molecular profiling shows that 82.1% of invasive tumours are hormone receptor-positive. A significant correlation is observed between the age of the patient and the SBR grade (p = 0.001) and with the hormone receptor expression (p = 0.001). In addition, the tumour grade is significantly correlated to oestrogen and progesterone receptor expression (p = 0.000; p = 0.000, respectively). Twenty-two per cent of cases were human epidermal growth factor receptor 2-positive. The Ki-67 proliferation index is expressed in 91% of breast cancer patients and was significantly associated with Scarff Bloom Richardson grade (p = 0.030), the progesterone receptor expression (p = 0.029) and with human epidermal growth factor receptor 2-positivity (p = 0.023). Primary breast cancer with a high grade is more frequent (31%) in young women under 40 years old, presenting 17% of our population. In summary, breast cancer patients in Algeria develop an unfavourable profile. Immunohistochemistry assay has played a pivotal role in assessing breast cancer predictive biomarkers improving the tumour behaviour and response to treatment.

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Correlation of hormone receptor and human epidermal growth factor Receptor-2/neu expression in breast cancer with various clinicopathologic factors

Cited by 19 publications

References 26 publications

Study of immune histo chemical markers in breast cancer and their correlation with various clinico pathological parameters at tertiary care center in Saurashtra region

Study of immune histo chemical markers in breast cancer and their correlation with various clinico pathological parameters at tertiary care center in Saurashtra region

Hormonal Receptors, Human Epidermal Growth Factor Receptor-2 and Triple Negative Immunohistochemical Typing of Women Breast Cancer in Kampala, Uganda.

Epidemiological profile and distribution of prognostic factors in invasive breast cancer among Algerian women

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