Correlation of Histomorphological Parameters as Biomarkers of Cervical Lymph Node Metastasis in Oral Squamous Cell Carcinoma: A Prospective Study

Abstract

Background: Histopathological parameters markers as potential predictive factors for LN metastasis. Objective: The study is designed to compare various histomorphological factors in Oral Squamous Cell Carcinoma with respect to Lymph Node metastasis. Materials and methods: A prospective, comparative study conducted at Bhagwan Mahaveer Cancer Hospital and Research Center Jaipur. Data regarding the histomorphological parameter were analyzed. Results: 100 cases of of oral squamous cell carcinoma were analyzed in present study.. Most common site for oral squamous cell carcinoma in this study was buccal mucosa in 62% of cases. In present study, of the total 79 cases with Grade 1 degree of differentiation, 31 cases had LN metastasis while 42 cases were negative for LN involvement. Out of 100 patients, 43 cases showed PNI while in 57 cases PNI was absent and 41 cases showed LVI while in 59 cases LVI was absent. Among 100 cases, 22 cases had marked lymphocytic response, 69 cases lymphocytic response was moderate while in 9 cases it was mild lymphocytic response. pattern comprising of WPOI IV& Vwere 31 and 45 respectively. Conclusion: Buccal mucosa was the commonest subsite of origin of primary carcinoma in the oral cavity and size of primary tumor did not affect the rate of cervical lymph node metastasis.