Correlation of Hippocampal Volume and Cognitive Performances in Patients with Either Mild Cognitive Impairment or Alzheimer's disease

Peng, Guoping; Zhan, Feng; He, Fangping; Chen, Zhongqin; Liu, Xiaoyan; Liu, Ping; Luo, Benyan

doi:10.1111/cns.12317

Cited by 69 publications

(63 citation statements)

References 38 publications

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“…12.1, p 17. The size of the decrease in volume is predictive of cognitive and brain impairments in e.Proofing http://eproofing.springer.com/journals/printpage.php?token=23-K... both humans (Allin et al 2001 ;Peng et al 2015 ) and rodents Colombel et al 2004 ;Goddyn et al 2006 ;Rosin et al 2015 ;Siraly et al 2015 ). Smaller brain volumes are also found in Ts65Dn mice when compared to euploids, with large effect sizes for the hippocampus, the cortex and the cerebellum (69%, 69% and 0.61, respectively).…”

Section: Heterogeneity Of Cognitive and Motor Abilities And Of Brain mentioning

confidence: 99%

Differential Brain, Cognitive and Motor Profiles Associated with Partial Trisomy. Modeling Down Syndrome in Mice

et al. 2017

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Section: Heterogeneity Of Cognitive and Motor Abilities And Of Brain mentioning

confidence: 99%

Differential Brain, Cognitive and Motor Profiles Associated with Partial Trisomy. Modeling Down Syndrome in Mice

et al. 2017

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“…No correlations were observed between left or right hippocampal volumes and memory indices, either at baseline or after two years of follow-up, in participants who remained cognitively normal. 31 Furthermore, some elders might maintain a high level of cognitive function for several years despite the presence of hippocampal atrophy, possibly because of cognitive reserve. 18,32 Unfortunately, we had no detailed information on histories of cognitive symptoms or performance of activities of daily living among our participants, nor are appropriate normative data available to determine normal vs. impaired cognition in American Indians.…”

Section: Discussionmentioning

confidence: 99%

Total Brain and Hippocampal Volumes and Cognition in Older American Indians

Cholerton

Omidpanah

Madhyastha³

et al. 2017

Alzheimer Disease &Amp; Associated Disorders

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Background Estimates of hippocampal volume by magnetic resonance imaging (MRI) have clinical and cognitive correlations and can assist in early Alzheimer’s disease (AD) diagnosis. However, little is known about the relationship between global or regional brain volumes and cognitive test performance in American Indians. Methods American Indian participants (n=698; median age 72 years) recruited for the Cerebrovascular Disease and its Consequences in American Indians study, an ancillary study of the Strong Heart Study cohort, were enrolled. Linear regression models assessed the relationship between MRI brain volumes (total brain and hippocampi) and cognitive measures of verbal learning and recall, processing speed, verbal fluency, and global cognition. Results After controlling for demographic and clinical factors, all volumetric measurements were positively associated with processing speed. Total brain volume was also positively associated with verbal learning, but not with verbal recall. Conversely, left hippocampal volume was associated with both verbal learning and recall. The relationship between hippocampal volume and recall performance was more pronounced among those with lower scores on a global cognitive measure. Controlling for APOE ε4 did not substantively affect the associations. Conclusions These results support further investigation into the relationship between structural AD biomarkers, cognition, genetics, and vascular risk factors in aging American Indians.

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“…Substantial alterations of neurogenesis in human patients suffering from Alzheimer's disease (AD), Huntingdon's disease (HD), and/or other cognitive impaired diseases were observed in different studies . Patients with AD have a smaller hippocampal volume, which is associated with cognitive deficits . A reduction of dopaminergic neurons in the SVZ is the hallmark of Parkinson's disease (PD).…”

Section: Adult Neurogenesis In Aging and Diseasementioning

confidence: 99%

Targeting Nicotinamide Phosphoribosyltransferase as a Potential Therapeutic Strategy to Restore Adult Neurogenesis

Wang

2016

CNS Neurosci Ther

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Adult neurogenesis is the process of generating new neurons throughout life in the olfactory bulb and hippocampus of most mammalian species, which is closely related to aging and disease. Nicotinamide phosphoribosyltransferase (NAMPT), also an adipokine known as visfatin, is the rate-limiting enzyme for mammalian nicotinamide adenine dinucleotide (NAD) salvage synthesis by generating nicotinamide mononucleotide (NMN) from nicotinamide. Recent findings from our laboratory and other laboratories have provided much evidence that NAMPT might serve as a therapeutic target to restore adult neurogenesis. NAMPT-mediated NAD biosynthesis in neural stem/progenitor cells is important for their proliferation, self-renewal, and formation of oligodendrocytes in vivo and in vitro. Therapeutic interventions by the administration of NMN, NAD, or recombinant NAMPT are effective for restoring adult neurogenesis in several neurological diseases. We summarize adult neurogenesis in aging, ischemic stroke, traumatic brain injury, and neurodegenerative disease and review the advances of targeting NAMPT in restoring neurogenesis. Specifically, we provide emphasis on the P7C3 family, a class of proneurogenic compounds that are potential NAMPT activators, which might shed light on future drug development in neurogenesis restoration.

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Correlation of Hippocampal Volume and Cognitive Performances in Patients with Either Mild Cognitive Impairment or Alzheimer's disease

Abstract: Current findings provide evidence of a close relationship between hippocampal volume and cognitive performances in patients with AD and aMCI, both at baseline and over follow-up.

Cited by 69 publications

References 38 publications

Differential Brain, Cognitive and Motor Profiles Associated with Partial Trisomy. Modeling Down Syndrome in Mice

Differential Brain, Cognitive and Motor Profiles Associated with Partial Trisomy. Modeling Down Syndrome in Mice

Total Brain and Hippocampal Volumes and Cognition in Older American Indians

Targeting Nicotinamide Phosphoribosyltransferase as a Potential Therapeutic Strategy to Restore Adult Neurogenesis

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