Correlation of high-risk human papilloma viruses but not of herpes viruses or Chlamydia trachomatis with endometriosis lesions

Assessment of Chlamydia trachomatis, Neisseria gonorrhoeae, and Mycobacterium tuberculosis infections in women undergoing laparoscopy: the role of peritoneal fluid sampling

“…Despite the paucity of studies which were the object of our qualitative synthesis, the 20-year temporal interval between the first study (published in 1996) and our study (published presently) denotes either a renewed or always alive interest to this topic. It is relevant that, in almost all of these studies (6,8,12,23), the clinical samples used were peritoneal or tubal fluids/tissues, which were tested alone (12; this study) and in combination with cervical (6) and serum (6,8) samples or with tissue samples from ovarian and endometrium lesions (23). Consistent with these studies, we found that endometriosis was not associated with peritoneal CT infection in women undergoing either a fertility or non-fertility diagnostic workup.…”

“…The APTIMA CT assay, used in the present study, is a second generation NAAT; it utilizes target capture, transcription-mediated amplification, and hybridization protection assay technologies to amplify chlamydial specific rRNA, which is then indicative of the presence of viable organisms. For this reason, the percentage of CT positive samples in our study was higher than that reported by other investigators (6,7,23). In a prospective study by Dietrich et al (7), CT was detected in the cervical, vaginal, and urethral specimens of 2 (0.9%) of 202 women; one patient with tubal occlusion of both tubes had a history of PID, and the other patient with tubal occlusion of one tube had no history of PID.…”

Virus Infection and Type I Interferon in Endometriosis

“…None of the clinical samples were positive for any of these four herpes viruses. In another study, 66 endometriosis samples from 56 patients were tested for the presence of EBV, CMV, HSV-1, HSV-2, VZV, and HHV6 by a PCR based analysis (Oppelt et al, 2010). Also this study failed to detect the presence of any of these six herpes viruses.…”

“…Only a few studies have addressed the possible involvement of a pathogenic virus in the aetiology of endometriosis (Oppelt et al, 2010;Vestergaard et al, 2010). The presence of specific human herpes viruses, human polyomaviruses, and human papillomaviruses was analysed.…”

“…The prevalence of HPV in endometriosis has been analysed (Oppelt et al, 2010;Vestergaard et al, 2010). In one study, no HPV DNA was found in the endometriosis samples from 32 patients (Vestergaard et al, 2010).…”