Correlation of hepatorenal dysfunction in pediatric malaria

Abstract

Background:Malaria is the most prevalent infectious diseases in the world. This study aims to assess the correlation of hepatorenal dysfunction in malaria patients in pediatric age group.Materials and Methodology:This study was conducted on patients of malaria admitted in the Department of Paediatrics, PBM hospital, Bikaner (Rajasthan), during resurgence of various outbreaks of malaria in the year 2011 and 2012. The diagnosis of malaria was confirmed by examination of thick and thin smear/optimal test; malarial hepatic and renal patients were included in the study.Results:The mean age of patients with hepatic and/or renal dysfunction in malaria was 5–10 years and preponderance of males. Association between hepatic and renal dysfunction was significant as 9 (40.9%) in 22 patients with serum bilirubin >3 mg/dl had renal failure in Plasmodium falciparum (PF) and 5 (71.43%) out of 7 patients in mixed (Plasmodium vivax [PV] and PF) patients. This association was not significant in PV as 6 (10.52%) out of 57 patient with serum bilirubin >3 mg/dl had renal failure.Conclusion:The specific reason for presenting our observation is to develop awareness regarding the early complications of malaria and to prevent them prompt action can be taken.

Clinicohematological and drug prescription details in children affected with malaria: A retrospective study from a tertiary hospital of an endemic region in India

“…17 We have observed male preponderance with male: female ratio (2:1), similar findings have been reported in earlier reports. 11 Fever was the most common symptom among all subtypes of malaria followed by vomiting (30.7%) and headache (20%). Fever was the single most important feature seen across all subtypes of malaria, which depends on the periodicity of rupture of schizonts.…”

“…37,38 In malaria, the liver function is deranged with hyperbilirubinemia and increased aminotransferase enzymes. 11,39,40 The bilirubin levels were significantly increased in mixed malaria and increased liver enzymes in falciparum malaria. The suggested pathophysiological is the increased hemolysis of infected of RBC with cholestasis and hepatitis.…”

“…[6][7][8][9][10] Further, all major organs like the brain, liver and renal can be affected by malaria, patients with hepatorenal dysfunction have poor prognosis. 11 A literature study suggests that the clinicohematological and treatment details of malaria caused by the different species have not been reported. Therefore, in this study, an attempt was made to understand the changes in laboratory parameters like haematology, hepato-renal among the paediatric malaria patients at a tertiary centre in Coastal Karnataka, India, which is documented to be an endemic region in India and the world.…”