Correlation of hepatitis virus serologic status with clinicopathologic features in patients undergoing hepatectomy for hepatocellular carcinoma

Abstract

(Groups II and IV) was 10 years younger than that of the HBsAg negative patients (Groups I and III). First Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan. RESULTS.The male-to-female ratio was higher in HCVAb negative groups (II and III). The HCVAb positive groups (I and IV) had a significantly poorer hepatic reserve and smaller resections than the HCVAb negative groups. Because the tumors were more advanced (as determined by TNM staging) in Group II, the 3-year crude and disease free survival rates were lower in Group II than in Group I. However, HCVAb negative groups (II and III), when compared at 5 years with the limited subsets of patients who had tumors at earlier stages or a curative resection, had significantly better crude and disease free 5-year survival rates than the HCVAb positive group (I). CONCLUSIONS. Clinicopathologic features differ from one another in accordancewith the viral seromarkers in HCC patients. Significantly better crude and disease free survival after complete resection were promising results for patients with non-HCV-related HCC. By comparison, for patients with HCV-related HCC, the risk of intrahepatic recurrences never subsided even in later years after complete resection. Therefore, posthepatectomy follow-up management should be individualized depending on the viral serologic status of HCC patients. quency of carcinogenesis between HCV-related and hepatitis B virus (HBV) -related liver diseases. With regard to surgery, it is also im-

A 6-month versus a 12-month surveillance for hepatocellular carcinoma in 559 hemophiliacs infected with the hepatitis C virus

“…A possible explanation for the high rates of multinodular HCC in hemophilic patients is that the tumor may originate as multiple distinct HCC clones generated by different HCV infections acquired through multiple infusions with virusinfected concentrates. 12,13 HCV per se might account for the high rates of multinodular cancer observed in hemophilic patients, as HCV is more involved in multicentric liver carcinogenesis than HBV, [14][15][16][17][18] and the presence of persistent inflammation and increased liver cell proliferation turnover is unequivocally an important factor in the occurrence of multicentric liver carcinogenesis. 19,20 Another possible explanation for the frequent occurrence of multinodular tumors in hemophiliacs could be the frequent coexistence of HCV and HBV infection.…”

Clinicopathological features of hepatocellular carcinomas (HCCs) arising in patients without chronic viral infection or alcohol abuse: a retrospective study of patients undergoing hepatic resection

“…4,5 It has also been accepted that the oncogenic mechanism and clinicopathological characteristics of HCCs critically depend on the type of hepatitis virus involved. [6][7][8][9] Patients with HBVrelated HCCs have a shorter history of viral infection and better liver function reserve than those with HCVrelated tumors. These features also prevail in the recurrence patterns in which the former preferentially recur with intrahepatic metastases through portal veins rather by than multicentric occurrence through a stepwise carcinogenesis process.…”

Clinicopathological characteristics of hepatitis B surface antigen-negative and hepatitis C antibody-negative hepatocellular carcinoma

“…This may be explained by the fact that repetitive therapy was possible, as these patients exhibited a good liver function reserve compared with those with virus-related HCC (13)(14)(15). However, the prognosis was not significantly different between patients with NBNC HCC and those with virus-related HCC for stage III and IV cases.…”