Correlation of hair risperidone concentration and serum level among patients with schizophrenia

Abstract

BackgroundRisperidone (RSP) has a rapid onset in vivo, low dosage and high plasma protein binding rate, therefore therapeutic drug monitoring (TDM) is needed to ensure safety in clinical treatment. However, compared with blood, hair is non-invasive, safe, non-infectious and easy to transport and store.AimsThis study aims to investigate the correlations among the drug concentrations of RSP in hair and serum, which provides an experimental basis to explore hair as a novel biomaterial to meet the needs of clinical detection.Methods34 patients with schizophrenia treated with RSP for more than 3 months were enrolled in this study. About 1 cm section of hair near the scalp was taken from the subjects, pretreated and detected by liquid chromatography-mass spectrometry. A correlation analysis was conducted among the drug concentrations in hair, the serum concentrations and the daily dosage. The data were analysed using SPSS 20.0 software.Results There was significant correlation between the hair concentration of RSP (two-tailed test, r=0.440, p=0.009) with the serum concentration of RSP, and the hair concentration of 9-hydroxyrisperidone (9-HR) with the serum concentration of 9-HR had no significant correlation (two-tailed test, r=−0.217, p=0.217); the total concentration of the RSP and 9-HR had no significant correlation between hair and serum (r=0.227, p=0.196). The dosage had no statistically significant correlation with the concentration of RSP in hair (r=0.207, p=0.241), 9-HR in hair (r=−0.194, p=0.271) and the total concentration of RSP and 9-HR in hair (r=0.188, p=0.288). There was no statistical correlation between the dosage and the concentration of RSP in serum (r=−0.059, p=0.741), but significant correlation between the dosage and 9-HR in serum (r=0.581 p<0.001) was found, and the correlation between the dosage and the total concentration of the two drugs RSP and 9-HR in serum was also significant (r=0.437, p=0.01).ConclusionThe correlation analysis showed that the concentration of RSP in hair was statistically significant with the serum RSP concentration. In this study, we provided some experimental basis for hair as a new biomaterial to monitor the therapeutic drug concentration.

Segmental analysis of antidepressant and antipsychotic drugs in the hair of schizophrenic patients

“… These results agreed with our findings regarding the correlations for clozapine and norclozapine. Our results are in line with those reported by Sun et al, who reported that dosage showed no significant correlation with the hair concentration of risperidone (r = 0.207, P = 0.241, n = 34) or 9‐OH‐risperidone (r = −0.194, P = 0.271, n = 34).…”

“…Information on administered doses and related hair concentrations has scarcely been reported for most antidepressants and antipsychotics. Some studies showed a good correlation between drug concentration in the proximal hair section of chronic users and administered dose, while other studies reported no correlation or a poor correlation . Moreover, many variables (hair melanin content, age, enzymatic activity, cosmetic hair treatment, and hair care habits) can cause large interindividual differences.…”

<p>Individual Perceived Stress Mediates Psychological Distress in Medical Workers During COVID-19 Epidemic Outbreak in Wuhan</p>

“…The female gender, younger age, and increased stress reactions were associated with the increased risk for depression. 37 As such, psychological inventions are required for both the medical workers and nonmedical staff. 38 This study has several limitations that should be taken into account.…”

Hair analysis of antidepressants and antipsychotics—Overview of quantitative data

“…A greater part of the controlled dose studies was done in the 1990s and early 2000s after which research on controlled dose studies seemed to decrease. The more recent work of Sun et al, 58 Licata et al, 23 and Wang et al 37 is, therefore, a favorable development toward a better understanding and statistical base of concentrations of antidepressants and antipsychotics in human hair. Collaboration with medical stations where patients are treated with antidepressants and antipsychotics serves as a good base for retrospective dose studies with a proper ethical foundation.…”