Correlation of granularity index with toxic granulation of neutrophils by manual microscopy and C-reactive protein

Tejeswini, Vaddatti

doi:10.9790/0853-0323539

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…Monocytes are also activated, resulting in increased cell volume and nucleic acid content. It has been reported that the more severely infected patients are, the more significant these morphological changes are (9,10). Mathy and Tejeswini also suggested that observing the content of neutrophil toxic granulation and immature granulocytes in peripheral blood smear can provide reference information for the diagnosis of bacterial infection (9,11).…”

Section: Introductionmentioning

confidence: 99%

The clinical value of hematological neutrophil and monocyte parameters in the diagnosis and identification of sepsis

Zhang¹,

Zhang²,

Pan³

et al. 2021

Ann Transl Med

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Section: Introductionmentioning

confidence: 99%

The clinical value of hematological neutrophil and monocyte parameters in the diagnosis and identification of sepsis

Zhang¹,

Zhang²,

Pan³

et al. 2021

Ann Transl Med

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Role of Automated Volume, Conductivity and Scatter (VCS) Parameters of Neutrophils as Indicators of Sepsis

Vaswani

Kakkar

Kwatra³

et al. 2022

Indian J Hematol Blood Transfus

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Comparison of the Predictive Values of Absolute Neutrophil Count, Absolute Band Count, and Toxic Granulation of Neutrophils with Serum Levels of C-reactive Protein for the Diagnosis of Bacterial Infections

هاشمی

بصیر²,

ربیعی

et al. 2018

AJCM

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Background and Objective: Correct and early diagnosis of infections contributes to proper treatment and helps prevent unnecessary antibiotic treatment. Thus, we aimed to compare the predictive values of the absolute neutrophil count, band count, and toxic granulation of neutrophils with the serum levels of C-reactive protein (CRP) in bacterial infections. Materials and Methods: In this descriptive cross-sectional study, we enrolled 200 patients who were admitted to the infectious disease ward of Sina Hospital, Hamadan, Iran, for bacterial infections in the first 6 months of 2016. The participants were chosen using the census sampling method. Before initiating the treatment, to carry out complete blood count (CBC) and quantitative CRP, 5 cc blood was obtained from the patients after obtaining their permission, and the percentages of neutrophils, band cells, and toxic granulation were evaluated in peripheral blood smear. This information and demographic data were collected by a checklist and analyzed by using SPSS, version 16. Results: The mean age of the patients was 56.26 years (range: 12 to 103 years), and 60.5% of the participants were male. The most frequent causes of hospitalization were pneumonia, soft tissue infections, sepsis, urinary tract infection, septic arthritis, and dysentery. The means of serum CRP, absolute neutrophil count, and band-cell count were 61.18 mg/L, 815.86 per mm 3 , and 318.86 per mm 3 , respectively. The correlation coefficients between quantitative CRP and absolute neutrophil count, band count, and toxic granulation severity were 0.43, 0.47, and 0.47, respectively. Conclusion: The results of the present study shows a linear correlation between CRP and the absolute neutrophil count, band count, and toxic granulation, indicating that these variables can replace CRP in the diagnosis of infections. Also, the predictive values of toxic granulation and band count for replacing CRP are equal and higher than that of absolute neutrophil count.

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Correlation of granularity index with toxic granulation of neutrophils by manual microscopy and C-reactive protein

Abstract: Background:During inflammation there is increase in plasma concentrations of C ReactiveProtein (CRP)

Cited by 3 publications

References 9 publications

The clinical value of hematological neutrophil and monocyte parameters in the diagnosis and identification of sepsis

The clinical value of hematological neutrophil and monocyte parameters in the diagnosis and identification of sepsis

Role of Automated Volume, Conductivity and Scatter (VCS) Parameters of Neutrophils as Indicators of Sepsis

Comparison of the Predictive Values of Absolute Neutrophil Count, Absolute Band Count, and Toxic Granulation of Neutrophils with Serum Levels of C-reactive Protein for the Diagnosis of Bacterial Infections

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