Correlation of gleason scores with magnetic resonance diffusion tensor imaging in peripheral zone prostate cancer

Liang, Li; Margolis, Daniel; Deng, Ming; Cai, Jie; Yuan, Ling; Feng, Zhaoyan; Min, Xiangde; Hu, Zhiquan; Hu, Daoyu; Liu, Jihong; Wang, Liang

doi:10.1002/jmri.24813

Cited by 41 publications

(38 citation statements)

References 40 publications

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“…These results are in agreement with previous literature where FA was reported higher for malignant tumors than for benign tumors . Similarly, low but measurable anisotropy values as the ones obtained in this study have been reported for cancers in other body organs, such as the prostate . Clinically, the use of DTI might complement standard DWI based on ADC solely.…”

Section: Discussionsupporting

confidence: 93%

Diffusion weighted imaging for the differentiation of breast tumors: From apparent diffusion coefficient to high order diffusion tensor imaging

Teruel

Goa

Sjøbakk

et al. 2015

Magnetic Resonance Imaging

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Section: Discussionsupporting

confidence: 93%

Diffusion weighted imaging for the differentiation of breast tumors: From apparent diffusion coefficient to high order diffusion tensor imaging

Teruel

Goa

Sjøbakk

et al. 2015

Magnetic Resonance Imaging

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“…The aforementioned studies (23,24) demonstrated that the second factor served a leading role, thus reducing the FA value. However, the results of the present study were consistent with those from Li et al (22). We hypothesize that the first factor affecting the FA value had a greater impact; the freedom of movement of water molecules was restricted and although prostate inherent normal fiber bundles were destroyed, this led to more freedom of movement of water molecules, but very little impact, therefore, higher FA values were observed in patients with higher Gleason grades.…”

Section: Discussionsupporting

confidence: 91%

“…In addition, Li et al (22) reported that for PCa Gleason scores ≤3+3, 3+4, 4+3 and ≥4+4, ADC values were 1.11±0.16x10 (24) indicated that FA values and Gleason scores were negatively correlated, suggesting that an increase in Gleason scores would cause a gradual reduction in FA value. The main factors affecting the FA values are as follows: i) Following an increase in Gleason scores, the proliferation of mesenchymal structure of fibers and more closely arranged cells are observed, resulting in higher FA values; and ii) following an increase in Gleason score, the cell carcinoma is poorly differentiated, atypia increases and erosion of the fibrous tissue structure is enhanced, resulting in fiber breakage, as well as disorganized and restricted water diffusion, thus leading to decreased FA values.…”

Section: Discussionmentioning

confidence: 99%

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Correlation of diffusion tensor imaging parameters and Gleason scores of prostate cancer

et al. 2017

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Abstract. The aim of the present study was to explore the association between the parameters of diffusion tensor imaging (DTI), including fractional anisotropy (FA) values, apparent diffusion coefficient (ADC) values and the diffusion tensor tractography (DTT) map, with the Gleason score of prostate cancer (PCa). A retrospective study of 50 cases of PCa confirmed by biopsy or surgical pathology was performed. Conventional magnetic resonance imaging and DTI scans were conducted in these cases. The 50 cases of PCa were divided into three groups, including low, intermediate and high grade, according to the Gleason score. Post-DTI processing was performed using Neuro 3D software, in order to measure the FA and ADC values, and map the prostate fibers. Differences in FA and ADC values among the various PCa groups were examined using analysis of variance, while the correlation of FA and ADC values with the Gleason score was studied using Pearson correlation analysis. The obtained DTT map clearly demonstrated the spatial structure of the prostate fibers. The fibers of the cancer area were dense without interruption in the low-grade group, sparse and disordered in the intermediate-grade group, and were disordered, sparse or even absent in the high-grade group. The FA values were 0.284±0.313, 0.293±0.347 and 0.369±0.347, respectively, with statistically significant differences observed among the three groups (F=234.533; P<0.05) and between each group (P<0.05). In addition, the FA value of PCa was positively correlated with the Gleason score (r=0.884; P<0.05). The ADC values of the low-, intermediate-and high-grade groups were 1.070±0.072x10 , respectively, which demonstrated statistically significant differences among the three groups (F=49.987; P<0.05) and between each group (P<0.05). Furthermore, the ADC values of PCa were negatively correlated with Gleason score (r=-0.810; P<0.05). In conclusion, there was an association between DTI parameters and Gleason score, which may be used to evaluate the grading and prognosis of PCa.

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“…[11] However, any correlation between perfusion parameters and Gleason score could not be demonstrated, which is usually present between Gleason score, and MRI perfusion findings. [12,13] The aim of our study was to investigate the relationship between CTP parameters and histopathological features of PCa tissue using a comprehensive, sector-wise approach.…”

Section: Introductionmentioning

confidence: 99%

Assessment of prostate cancer with integrated CT-perfusion using a sector-wise approach

Ferrari¹,

Huellner²,

Pauli³

et al. 2017

Turkish Journal of Urology

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Objective: The role of computed tomography perfusion (CTP) in characterizing primary prostate cancer (PCa) is not definitely known. The aim of the present study was to investigate the relationship between CTP parameters and histopathological features of PCa tissue, using a sector-wise approach. Material and methods:Fifty-one patients with biopsy-proven PCa underwent prospectively a CTP scan prior to radical prostatectomy. Blood flow (BF), mean blood volume (BV) and mean transit time (MTT) were calculated, with the prostate being divided into eight sectors. Corresponding sector-wise histopathological analysis of whole-mount prostatectomy specimens was performed to determine tumoral area (mm Conclusion: BF correlates weakly with size and vascularity of PCa. There is a need for further studies to elucidate the association between CTP parameters and other histopathological parameters.

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Correlation of gleason scores with magnetic resonance diffusion tensor imaging in peripheral zone prostate cancer

Abstract: Quantitative DTI at 3.0T MRI shows a significant association with GS in the evaluation of tumor aggressiveness in peripheral zone PCa, which may be useful to ensure concordance of biopsy results and therefore make the appropriate decision in the management of patients with PCa.

Cited by 41 publications

References 40 publications

Diffusion weighted imaging for the differentiation of breast tumors: From apparent diffusion coefficient to high order diffusion tensor imaging

Diffusion weighted imaging for the differentiation of breast tumors: From apparent diffusion coefficient to high order diffusion tensor imaging

Correlation of diffusion tensor imaging parameters and Gleason scores of prostate cancer

Assessment of prostate cancer with integrated CT-perfusion using a sector-wise approach

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