Correlation of FGFR2 rs2981582 polymorphisms with susceptibility to breast cancer: a case-control study in a Chinese population

Abstract

ObjectiveBreast cancer (BC) is a common malignancy among women worldwide. Fibroblast growth factor receptor 2 (FGFR2) rs2981582 is reported to play a vital role in BC development. However, the relationship between them remains unclear.MethodsNinety-five patients and 140 healthy controls were enrolled in the study. Plasma DNA was genotyped by the MassARRAY method. A meta-analysis was conducted to clarify the effect of FGFR2 polymorphism on BC risk.ResultsOur case-control study results revealed a significant difference in CC, TC, and TT genotypes between patients and controls. Logistic regression analysis showed that TT and TC genotype and the dominant mode were significantly correlated with BC development [odds ratio (OR) = 1.21, 95% confidence interval (CI): 1.050–2.27; OR = 1.81, 95% CI: 1.24–2.73; OR = 2.15, 95% CI: 1.25–5.31, respectively], even after adjusting for age, body weight, drinking, smoking, and estrogen receptor status. A meta-analysis of 15 studies showed significant differences among the dominant, recessive, heterozygote, and homozygote models between patients and controls.ConclusionsOur results showed an association of FGFR2 rs2981582 polymorphism with BC in an Asian population. However, a more comprehensive study of the relationship between the polymorphism and BC is still needed.

Hydrogen Evolution, Oxygen Evolution, and Oxygen Reduction at Polarizable Liquid|Liquid Interfaces

“…DMFc [8,19] remains the most popular electron donor for biphasic HER and ORR in the dark. Clearly, its low redox potential, solubility in organic solvents, extremely low solubility in water and relative stability of DMFc + cation is superior.…”

“…The suitable conditions for biphasic ORR are the same as for biphasic HER except oxygen is not removed from the system. When ferrocene derivative solution in hydrophobic polar solvent [19,42,[83][84][85][86][87][88][89][90][91] or in hydrophobic ionic liquid (IL) [92,93] is in contact with aqueous acidic solution, 2 electrons ORR occurs:…”

“…The formation of oxidised form of electron donor in the organic phase was detected by cyclic voltammetry and UV-vis spectroscopy. [19] H 2 O 2 was detected by colorimetry and UV-vis spectroscopy after the addition of starch and iodide [19] or titanium oxalate and acid [85] to the aqueous phase. Electrochemical oxidation of H 2 O 2 at SECM probe [42,84,86,[90][91][92][93][94][95] or observation of fluorescence of the dye produced by enzymatic H 2 O 2 reduction [90,92] were also applied.…”

“…[12,13] Two electron oxygen reduction reaction (ORR) [14] produces another important chemical and energy carrier: hydrogen peroxide [15][16][17][18] and this reaction may occur at the liquid j liquid interface. [19] Electrons capable to reduce hydrated H + cations or O 2 molecules can be delivered electrochemically, by application of light or in both ways. The withdrawal of electrons from H 2 O molecule produces oxygen.…”

Biological Significance and Targeting of the FGFR Axis in Cancer

“…Risk alleles of various SNPs found in FGFR2, they are associated with ER-positive cancers [135], increased FGFR2 expression [136], lymph node metastasis in breast cancer [137] and radiation-induced breast cancer risk [138]. More recently another study identified an FGFR2 SNP that was linked with susceptibility to breast cancer in a Chinese population [139]. However, only a few SNP loci are confirmed in FGFR1 that correlate significantly with a breast cancer predisposition [140].…”