Correlation of fetal scalp blood sampling pH with neonatal outcome umbilical artery pH value

Kuehnle, Elna; Herms, S.; Kohls, Fabian; Kundu, Sudip; Hillemanns, Peter; Staboulidou, I.

doi:10.1007/s00404-016-4053-6

Cited by 7 publications

(8 citation statements)

References 30 publications

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“…196 Blood pH level is such a key factor in evaluating health that obstetricians use it to inform their decisions on their delivery method for pregnancies. 194 When the fetal scalp blood pH was 7.20 or lower, a doctor would have to make the decision to perform a c-section or an instrumental vaginal delivery in order to avoid complications (Figure 6c shows good correlation between fetal scalp pH value and outcome umbilical pH value, used to study the reliability of fetal scalp pH values). 194 However, results may not always be reliable and can be false at times.…”

Section: Bloodmentioning

confidence: 99%

“…194 When the fetal scalp blood pH was 7.20 or lower, a doctor would have to make the decision to perform a c-section or an instrumental vaginal delivery in order to avoid complications (Figure 6c shows good correlation between fetal scalp pH value and outcome umbilical pH value, used to study the reliability of fetal scalp pH values). 194 However, results may not always be reliable and can be false at times. It was recommended to take at least two samples before making a decision as close to the time of delivery as possible.…”

Section: Bloodmentioning

confidence: 99%

“…It was recommended to take at least two samples before making a decision as close to the time of delivery as possible. 194 There is also direct correlation between pH and the presence of cancer cells in the blood (tumor cells). Mani et al developed a working ZnO-based microfluidic pH sensor as a tool to examine circulating tumor cells (Figure 6d).…”

Section: Bloodmentioning

confidence: 99%

“…(b) Blood–brain barrier ion transporters and channels . (c) pH before birth and after birth, showing good correlation between fetal scalp pH value and outcome pH value and used to study the reliability of fetal scalp pH values, (d) Microfluidic device fabrication scheme for ZnO-based pH sensor with open circuit potential (OCP) configuration, with −43.71 mV/pH sensitivity, drift of 3 mV/h, and response times between 26 and 32 s in the 1.68–9.18 pH range . Reproduced with permission from refs , , , and , respectively.…”

Section: Ph Regulation In the Human Bodymentioning

confidence: 99%

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Recent Progress in Electrochemical pH-Sensing Materials and Configurations for Biomedical Applications

et al. 2019

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pH-sensing materials and configurations are rapidly evolving toward exciting new applications, especially those in biomedical applications. In this review, we highlight rapid progress in electrochemical pH sensors over the past decade (2008–2018) with an emphasis on key considerations, such as materials selection, system configurations, and testing protocols. In addition to recent progress in optical pH sensors, our main focus in this review is on electromechanical pH sensors due to their significant advances, especially in biomedical applications. We summarize developments of electrochemical pH sensors that by virtue of their optimized material chemistries (from metal oxides to polymers) and geometrical features (from thin films to quantum dots) enable their adoption in biomedical applications. We further present an overview of necessary sensing standards and protocols. Standards ensure the establishment of consistent protocols, facilitating collective understanding of results and building on the current state. Furthermore, they enable objective benchmarking of various pH-sensing reports, materials, and systems, which is critical for the overall progression and development of the field. Additionally, we list critical issues in recent literary reporting and suggest various methods for objective benchmarking. pH regulation in the human body and state-of-the-art pH sensors (from ex vivo to in vivo) are compared for suitability in biomedical applications. We conclude our review by (i) identifying challenges that need to be overcome in electrochemical pH sensing and (ii) providing an outlook on future research along with insights, in which the integration of various pH sensors with advanced electronics can provide a new platform for the development of novel technologies for disease diagnostics and prevention.

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Section: Bloodmentioning

confidence: 99%

Section: Bloodmentioning

confidence: 99%

Section: Bloodmentioning

confidence: 99%

Section: Ph Regulation In the Human Bodymentioning

confidence: 99%

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Recent Progress in Electrochemical pH-Sensing Materials and Configurations for Biomedical Applications

et al. 2019

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“…In addition, the influence of CTG variations and the time delay between FBGA and delivery on the accuracy of FBGA is unclear. Kuehnle et al, [ 7 ] for example, assessed the correlation between FBGA-based pH values and umbilical arterial pH values after delivery. They described significant differences in 40 of 83 fetuses with an FBGA pH result <7.20.…”

Section: Introductionmentioning

confidence: 99%

Accuracy of intrapartum fetal blood gas analysis by scalp sampling

Hilal

Mrkvicka²,

Rezniczek³

et al. 2017

Medicine

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Fetal blood gas analysis (FBGA) using scalp blood is commonly used to identify serious fetal distress. However, there is a lack of data regarding its accuracy and reliability. The aim of this study was to determine the positive predictive value (PPV) and negative predictive value (NPV) of FBGA for predicting postpartum acidosis in case of nonreassuring fetal heart rate tracings (NRFHRT). To this end, we conducted a retrospective cohort study of singleton term deliveries with NRFHRT according to Fédération Internationale de Gynécologie et d’Obstétrique and Fisher cardiotocography scores undergoing FBGA in a university hospital. The PPV and NPV of FBGA regarding neonatal acidosis (defined as a pH value ≤ 7.15 in arterial or venous umbilical cord blood) and Apgar scores indicating neonatal depression (defined as a 5-min Apgar score ≤5) were evaluated. Multivariate analysis was used to determine the influence of cardiotocography variations and the time delay between FBGA and delivery on the accuracy of FBGA. We analyzed 343 deliveries with NRFHRT. In 32 (9%) of these cases, fetal acidosis was confirmed by a postpartum umbilical cord blood pH value ≤ 7.15. In 308/343 (90%) cases, FBGA identified NRFHRT as false positive (as confirmed by nonacidotic postpartum pH values) and thus avoided unnecessary interventions such as operative delivery. The overall test accuracy of FBGA was 91%. FBGA accurately predicted postpartum cord blood pH values with a margin of ±0.2 in 319/343 (93%) cases. On the other hand, the false negative rate of FBGA was 8% (29/343). The PPV and NPV of FBGA for predicting postpartum acidosis were 50% and 91%, respectively. The sensitivity was 9% and the specificity was 99%. In a multivariate logistic regression analysis, maternal body mass index (odds ratio [OR] 1.1; 95% confidence interval [CI] 1.01–1.17; P = .029) and cardiotocography variations (OR 0.80; 95% CI 0.66–0.98; P = .029) independently affected the predictive value of FBGA. The PPV of FBGA regarding neonatal depression according to Apgar scores was low with only 17%. We conclude that FBGA may be used in clinical practice to rule out, but not to rule in, neonatal acidosis in parturients with NRFHRT. It can avoid unnecessary interventions such as cesarean section or operative vaginal delivery in up to 90% of cases, but cannot reliably detect fetal acidosis.

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Estimation of neonatal outcome artery pH value according to CTG interpretation of the last 60 min before delivery: a retrospective study. Can the outcome pH value be predicted?

Kundu

Kuehnle

Schippert

et al. 2017

Arch Gynecol Obstet

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Correlation of fetal scalp blood sampling pH with neonatal outcome umbilical artery pH value

Cited by 7 publications

References 30 publications

Recent Progress in Electrochemical pH-Sensing Materials and Configurations for Biomedical Applications

Recent Progress in Electrochemical pH-Sensing Materials and Configurations for Biomedical Applications

Accuracy of intrapartum fetal blood gas analysis by scalp sampling

Estimation of neonatal outcome artery pH value according to CTG interpretation of the last 60 min before delivery: a retrospective study. Can the outcome pH value be predicted?

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