Correlation of Femoral Intima-Media Thickness and the Severity of Coronary Artery Disease

Kirhmajer, Majda Vrkić; Banfić, Ljiljana; Vojković, Marina; Strozzi, Maja; Bulum, Joško; Miovski, Zoran

doi:10.1177/0003319710375087

Cited by 30 publications

(37 citation statements)

References 29 publications

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“…[2630–32] In our study, we could not find any association for diabetes, hypertension, and smoking with carotid and aortic IMT. However, there were significant associations between age and dyslipidemia, and carotid and aortic IMT.…”

Section: Discussioncontrasting

confidence: 69%

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Significance of the Intima-Media thickness of carotid and thoracic aorta in coronary artery disease in the South Indian population

et al. 2011

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Background:Ultrasound detected intima-media thickness (IMT) of the carotid artery and thoracic aorta are possible screening tests to assess the risk of coronary artery disease (CAD) in asymptomatic individuals.Objective:Aim of the study was to assess the utility of carotid and aortic IMT as a predictor of CAD and to assess the extent of IMT with severity of CAD in a South Indian population.Patients and Methods:A cross-sectional and analytical study was carried out among 40 cases, who had angiographic evidence of CAD against 30 healthy control subjects with a normal treadmill test. At plaque-free regions, the carotid IMT was evaluated by B-mode ultrasonography and thoracic aorta IMT was evaluated by trans-esophageal echocardiography (TEE). The significance of difference in means between two groups was analyzed using one-way ANOVA F-test and the significance of difference in proportions by Chi-square test. Multiple comparisons were done by Bonferroni t test. The correlation between IMT and severity of CAD was assessed by Spearman's method.Results:There were 38 males and 2 females among cases with age 51.7 ± 8.3 years, and 28 males and 2 females among control subjects with age 52.2 ± 7.1 years. Increased carotid IMT was noted among 24 cases and 2 control subjects, and the association was significant for CAD [P < 0.001, Chi-square = 20.89, odds ratio (OR) = 21.00, and 95% confidence interval (CI) = 4.78-89.59]. Similarly, 19 cases and one control subject had abnormal IMT with positive correlation for CAD (P < 0.001, Chi-square = 16.39, OR = 28.24, and 95% CI = 4.06-163.21). There was no association between IMT and diabetes, hypertension, or smoking; however, IMT was significantly associated with age and dyslipidemia. Also, there was no correlation between extent of IMT and severity of CAD.Conclusions:IMT of the carotid and thoracic aorta is strongly associated with risk of CAD in a South Indian population, and may be used as a non-invasive screening tool for coronary atherosclerosis in resource-limited settings. The presence of dyslipidemia influenced IMT and may be used as a tool to follow patients on hypolipidemic drugs.

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Section: Discussioncontrasting

confidence: 69%

“…Healthy age- and sex-matched control subjects[26] without evidence of cardiac diseases or symptoms were included. Control subjects had a normal treadmill test (TMT).…”

Section: Methodsmentioning

confidence: 99%

Significance of the Intima-Media thickness of carotid and thoracic aorta in coronary artery disease in the South Indian population

et al. 2011

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“…Our findings are consistent with previous studies. A number of studies demonstrated that there were significant correlations between femoral artery atherosclerosis and cardiovascular risk factors [25, 26]. A study by Kirhmajer et al reported that femoral intima-media was correlated with BMI ( r = 0.16, p = 0.036), high-density lipoprotein ( r = − 0.30, p = 0.0003), and triglycerides ( r = 0.19, p = 0.17) [26].…”

Section: Discussionmentioning

confidence: 99%

“…A number of studies demonstrated that there were significant correlations between femoral artery atherosclerosis and cardiovascular risk factors [25, 26]. A study by Kirhmajer et al reported that femoral intima-media was correlated with BMI ( r = 0.16, p = 0.036), high-density lipoprotein ( r = − 0.30, p = 0.0003), and triglycerides ( r = 0.19, p = 0.17) [26]. An AWHS study showed that the presence of subclinical femoral atherosclerotic plaque was associated with cardiovascular risk factors, such as dyslipidemia (OR, 1.46; 95% CI, 1.17–1.83), hypertension (OR, 1.66; 95% CI, 1.31–2.10), current smoking (OR, 3.88; 95% CI, 3.01–5.00), and diabetes (OR, 2.11; 95% CI, 1.20–3.70) [3].…”

Section: Discussionmentioning

confidence: 99%

Assessment of longitudinal distribution of subclinical atherosclerosis in femoral arteries by three-dimensional cardiovascular magnetic resonance vessel wall imaging

Han

Guan

Zhu

et al. 2018

Journal of Cardiovascular Magnetic Resonance

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BackgroundLower extremity peripheral artery disease has become a significant health burden worldwide. Since the treatment strategies can be different if atherosclerotic disease involves different femoral artery segments, it is important to assess plaque distribution among different segments of femoral arteries. We sought to investigate the longitudinal distribution of subclinical femoral artery atherosclerosis in asymptomatic elderly adults using cardiovascular magnetic resonance (CMR) vessel wall imaging.MethodsAsymptomatic elderly subjects underwent three-dimensional (3D) CMR vessel wall imaging for femoral arteries. The 3D motion sensitized-driven equilibrium prepared rapid gradient-echo (3D-MERGE) sequence was acquired from the common femoral artery to the popliteal artery. The femoral artery was divided into 4 segments: common femoral artery (CFA), proximal superficial femoral artery (pSFA), adductor canal (AC) segment of femoral artery, and popliteal artery (PA). The morphological characteristics including lumen area, wall area, maximum and minimum wall thickness, normalized wall index (NWI = wall area / [lumen area + wall area] × 100%), and eccentricity index ([maximum wall thickness - minimum wall thickness] / maximum wall thickness), luminal stenosis, and presence of atherosclerotic plaque were evaluated and compared between bilateral sides and among different femoral artery segments in each side of femoral artery. The associations between ankle-brachial index (ABI) and cardiovascular risk factors and femoral artery plaque characteristics were also determined.ResultsOf 107 recruited subjects (71.9 ± 5.6 years; 48 males), 70 (65.4%) were found to have femoral artery plaques. The atherosclerotic plaques were most frequently found in PA (41.1%) and CFA (40.2%) segments, followed by pSFA (31.8%) and AC (23.4%) segments (p = 0.002). Similarly, PA and CFA segments showed significantly greater maximum wall thickness and eccentricity index compared with pSFA and AC segments (all p < 0.001). Significant differences can be found in NWI among four segments of femoral arteries (p < 0.001) and PA showed the highest NWI (54.8%), followed by AC (54.3%), pSFA (52.4%) and CFA (45.9%) segments. Compared with right femoral artery, left femoral artery had significant smaller lumen area and greater NWI in most of segments (p < 0.002). There were no significant differences in ABI between subjects with and without atherosclerotic plaques (p = 0.161). The presence of subclinical atherosclerotic plaque in femoral arteries was significantly associated with cardiovascular risk factors including age (odds ratio [OR], 1.133; 95% confidence interval [CI], 1.048–1.224, p = 0.002), male gender (OR, 3.914; 95% CI, 1.612–9.501, p = 0.003), and hypertension (OR, 4.000; 95% CI, 1.700–9.411, p = 0.001), respectively.ConclusionsSubclinical femoral artery atherosclerosis is prevalent in the elderly population, particularly in the left femoral artery and segments of CFA and PA, and is associated with age, male gender and hypertension. Our find...

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“…[9][10][11] Emerging evidence suggests that the femoral IMT has similar significant associations. 8,[12][13] Atherosclerotic scores incorporating data from angiograms of the common carotid and internal carotid arteries, carotid bifurcation, and femoral artery have been associated with far better assessments of the extent and severity of coronary artery disease than individual IMTs of either the carotid or femoral artery. [14][15][16] First Department of Cardiology, Athens Medical School Hippokration Hospital, Athens, Greece.…”

mentioning

confidence: 99%

Association of Total Atherosclerotic Burden with Progression of Penile Vascular Disease

IoakeimidisNikolaos¹,

TsokanisAthanasios²,

VlachopoulosCharalambos³

et al. 2014

Journal of Men's Health

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Background: Erectile dysfunction (ED) is an early manifestation of a generalized arterial disease. The association between penile vascular disease progression and total atherosclerotic burden was investigated using a classification that incorporates ultrasonographic assessments of intima media thickness (IMT) and plaques from both the carotid and femoral arteries. Methods: Sixty-five ED patients (mean age, 56 -10 yrs) were evaluated for cavernous vascular disease severity using penile Doppler ultrasound. Ultrasonographic assessments of IMT, lumen diameter, and plaques in the carotid and femoral arteries were evaluated, and patients were classified according to an ultrasound-based morphological system. Results: Based on the results of ultrasonic assessments, patients were divided into two groups-a high-score group and a low-score group. Patients in the high-score group had increased intima-media ( > 1.0 mm) and/or plaque in any of the four arteries. Patients in the low-score group had normal carotid and femoral IMT and an absence of plaques in all four arteries. While the two groups did not differ in blood pressure parameters, metabolic profile, and smoking status, high-score patients (n = 31) had significantly decreased age-adjusted peak systolic velocity (25.2 cm versus 32.3 cm/s, P < 0.01) and a longer duration of ED (3.8 years versus 2 years, P < 0.05), compared with low-score patients (n = 34). In the high-score group, score level was inversely correlated with peak systolic velocity after adjusting for age and systolic blood pressure (b = -0.322, P = 0.025). There also was a positive linear relation of ED duration with prevalence of high score (P < 0.05). Conclusions: In patients with vasculogenic ED, ultrasound findings of penile vasculature damage and longstanding ED correlate significantly with increasing carotid and femoral atherosclerotic burden. These data suggest a close interrelationship between progression of vasculogenic ED and peripheral atherosclerosis.

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Correlation of Femoral Intima-Media Thickness and the Severity of Coronary Artery Disease

Cited by 30 publications

References 29 publications

Significance of the Intima-Media thickness of carotid and thoracic aorta in coronary artery disease in the South Indian population

Significance of the Intima-Media thickness of carotid and thoracic aorta in coronary artery disease in the South Indian population

Assessment of longitudinal distribution of subclinical atherosclerosis in femoral arteries by three-dimensional cardiovascular magnetic resonance vessel wall imaging

Association of Total Atherosclerotic Burden with Progression of Penile Vascular Disease

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