Correlation of facial sebum to serum insulin-like growth factor-1 in patients with acne

Vora, Sheetal D; Ovhal, Ajay Govindrao; Jerajani, Hemangi; Nair, Nandini; Chakrabortty, Amit

doi:10.1111/j.1365-2133.2008.08764.x

Cited by 106 publications

(90 citation statements)

References 9 publications

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“…In sebocytes, IGF-1 -along with androgens -stimulates proliferation and lipogenesis. Serum IGF-1 levels correlate positively with facial sebum secretion in male acne patients [ 19 ] and are higher in acne patients compared to control subjects [ 20,21 ] . Insulin-like growth factor 1 inhibits the transcription factor FoxO1 [ 22 ] .…”

Section: Pathogenesismentioning

confidence: 96%

Acne

Degitz

Ochsendorf

2017

J Deutsche Derma Gesell

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Summary Acne is a chronic disease with a high prevalence among adolescents. Key pathogenetic factors (and their clinical correlates) are increased sebum production (seborrhea), follicular hyperkeratosis (comedones), and perifollicular inflammation (papules and pustules). The disease is modulated by a variety of endogenous (androgens, IGF‐1, neuroendocrine factors) and exogenous (Propionibacterium acnes, diet, friction, ingredients of medical or cosmetic topical products) triggers. Acne is associated with high morbidity, and even mild manifestations may potentially cause considerable impairment in quality of life. Effective topical and systemic treatments are available. Optimal therapeutic results require continuous patient management over the course of the entire treatment period as well as adjustment of treatment modalities based on symptoms and disease severity.

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Section: Pathogenesismentioning

confidence: 96%

Acne

Degitz

Ochsendorf

2017

J Deutsche Derma Gesell

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“…Substance P induces the expression of neutral endopeptidase, a potent NP-degrading enzyme, in sebaceous germinative rate and serum IGF-I levels has been demonstrated in postadolescent acne patients. 51 IGF-I has been localised to the peripheral cells of sebaceous glands in the rat, 52 while in human skin the strongest expression of IGF-I protein has been found in maturing sebocytes and suprabasal cells of sebaceous ducts. 53 The expression of IGF-I receptor mRNA is the strongest in basal cells of sebaceous glands and immature sebocytes, whereas IGF-I receptor protein expression was uniform and intense in all regions of the gland.…”

Section: Effects Of Hormones On Sebaceous Gland Cellsmentioning

confidence: 99%

An update on the role of the sebaceous gland in the pathogenesis of acne

Makrantonaki

Gancevičienė²,

Zouboulis³

2011

Dermato-Endocrinology

230

168

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“…152 acne lesion counts and facial sebum secretion rate have been reported. [175][176][177] IGF-1 stimulates 5α-reductase, adrenal and gonadal androgen synthesis, AR signal transduction, sebocyte proliferation and lipogenesis. [178][179][180][181][182][183][184] Milk consumption results in a significant increase in IGF-1 serum level and exerts strong insulinotropic effects comparable to high glycaemic food.…”

Section: Interleukin-1α Network In Keratinocytesmentioning

confidence: 99%

Role of FGFR2-signaling in the pathogenesis of acne

Melnik

2009

Dermato-Endocrinology

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It is the purpose of this review to extend our understanding of the fibroblast growth factor (FGF) receptor-2b-signaling network in the pathogenesis of acne. A new concept of the role of FGFR2b-signaling in dermal-epithelial interaction for skin appendage formation, pilosebaceous follicle homeostasis, comedogenesis, sebaceous gland proliferation and lipogenesis is presented. The FGFR2-gain-of-function mutations in Apert syndrome and unilateral acneiform nevus are most helpful model diseases pointing the way to androgen-dependent dermalepithelial FGFR2-signaling in acne. Androgen-mediated upregulation of FGFR2b-signaling in acne-prone skin appears to be involved in the pathogenesis of acne vulgaris. In organotypic skin cultures, keratinocyte-derived interleukin-1α stimulated fibroblasts to secrete FGF7 which stimulated FGFR2b-mediated keratinocyte proliferation. Postnatal deletion of FGFR2b in mice resulted in severe sebaceous gland atrophy. The importance of FGFR2b in sebaceous gland physiology is further supported by the mode of action of anti-acne agents which have been proposed to attenuate FGFR2b-signaling. Downregulation of FGFR2b-signaling by isotretinoin explains its therapeutic effect in acne. Downregulation of FGFR2b-signaling during the first trimester of pregnancy disturbs branched morphogenesis and explains retinoid embryotoxicity. Insulin-like growth factor-1 (IGF-1), the mediator of growth hormone during puberty, intracts with androgen-dependent FGFR2b-signaling and links androgen-and FGF-mediated signal transduction important in sebaceous gland homeostasis. The search for a follicular defect in the dermalepithelial regulation of growth factor-signaling in acne-prone skin appears to be a most promising approach to clarify the pathogenesis of acne.

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Correlation of facial sebum to serum insulin-like growth factor-1 in patients with acne

Cited by 106 publications

References 9 publications

Acne

Acne

An update on the role of the sebaceous gland in the pathogenesis of acne

Role of FGFR2-signaling in the pathogenesis of acne

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