Correlation of Endometrial Dating with Basal Body Temperature and Menses

Noyes, R. W.; Haman, John O.

doi:10.1016/s0015-0282(16)31446-7

Cited by 131 publications

(33 citation statements)

References 3 publications

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“…Adenomyosis was defined by the presence of endometrial glands and stroma in >25% of myometrial thickness [15]. Menstrual cycle specimens were classified according to the phase of the menstrual cycle into early, mid, late proliferative (EP, MP, LP) and early, mid, late secretory (ES, MS, LS), using histological criteria [16]. Postmenopausal specimens had atrophic endometrium (AT).…”

Section: Methodsmentioning

confidence: 99%

Phenotypic Characterisation of the Inner and Outer Myometrium in Normal and Adenomyotic Uteri

Mehasseb

Bell

Brown

et al. 2010

Gynecol Obstet Invest

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Background and Aim: To study the characteristics of the inner (IM) and outer (OM) myometrium in the presence and absence of uterine adenomyosis. Methods: Case control blinded comparison carried out in a university department. Morphometric features of the myometrium were studied in uteri from pre- and postmenopausal women with and without uterine adenomyosis as the sole pathology. Uteri were also divided according to the phase of the cycle and examined using immunohistochemistry and image analysis. Results: Cell density and total nuclear area were statistically significantly greater in the IM compared to OM, in pre- and postmenopausal women, in both the adenomyosis and control uteri. The difference in nuclear size was statistically significant only in the premenopausal group. The change from the IM to the OM in cell density and total nuclear area was gradual with no distinct zonation. Examined features did not vary with cycle phase. Both the IM and OM in adenomyosis exhibited lower cell density and larger nuclei compared to controls. In adenomyosis, immunostaining for α-smooth muscle actin, desmin and Ki-67 was consistent with myometrial hyperplasia and hypertrophy. Conclusions: There are clear differences between the IM and the OM but the transition is gradual, with no distinct zonation. Adenomyosis is characterised by reduced cell density, and increased nuclear size and features of hyperplasia and hypertrophy that are not confined to the IM.

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Section: Methodsmentioning

confidence: 99%

Phenotypic Characterisation of the Inner and Outer Myometrium in Normal and Adenomyotic Uteri

Mehasseb

Bell

Brown

et al. 2010

Gynecol Obstet Invest

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“…Fixed sections of endometriosis lesions were evaluated after staining with hematoxylin and eosin, and only those that contained both glandular and stromal compartments were used for this study. Dating of eutopic endometrial histological features 18 and serum hormone measurements were used to confirm menstrual cycle phase. Endometriosis stage was provided during surgery using the revised American Society of Reproductive Medicine classification (I, 60%; II, 20%; III, 20%).…”

Section: Human Tissuesmentioning

confidence: 99%

Estradiol Is a Critical Mediator of Macrophage-Nerve Cross Talk in Peritoneal Endometriosis

Greaves

Temp

Esnal-Zufiurre

et al. 2015

The American Journal of Pathology

135

121

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Endometriosis occurs in approximately 10% of women and is associated with persistent pelvic pain. It is defined by the presence of endometrial tissue (lesions) outside the uterus, most commonly on the peritoneum. Peripheral neuroinflammation, a process characterized by the infiltration of nerve fibers and macrophages into lesions, plays a pivotal role in endometriosis-associated pain. Our objective was to determine the role of estradiol (E2) in regulating the interaction between macrophages and nerves in peritoneal endometriosis. By using human tissues and a mouse model of endometriosis, we demonstrate that macrophages in lesions recovered from women and mice are immunopositive for estrogen receptor b, with up to 20% being estrogen receptor a positive. In mice, treatment with E2 increased the number of macrophages in lesions as well as concentrations of mRNAs encoded by Csf1, Nt3, and the tyrosine kinase neurotrophin receptor, TrkB. By using in vitro models, we determined that the treatment of rat dorsal root ganglia neurons with E2 increased mRNA concentrations of the chemokine C-C motif ligand 2 that stimulated migration of colony-stimulating factor 1edifferentiated macrophages. Conversely, incubation of colony-stimulating factor 1 macrophages with E2 increased concentrations of brainderived neurotrophic factor and neurotrophin 3, which stimulated neurite outgrowth from ganglia explants. In summary, we demonstrate a key role for E2 in stimulating macrophage-nerve interactions, providing novel evidence that endometriosis is an estrogen-dependent neuroinflammatory disorder. Endometriosis affects 10% of reproductive age women and is associated with persistent pelvic pain. 1 It is defined by the presence of endometrial-like tissue (lesions) found outside the uterus, most commonly on the peritoneum. The mechanisms underlying endometriosis-associated pain are poorly understood, but it has been postulated that estrogen-dependent neuroinflammation may be involved. 2 Notably, the presence of endometrial tissue fragments on the peritoneum elicits an immune response, including recruitment of macrophages, 3 blood vessels, and nerve fibers into the resultant lesions. 4,5 Within the lesions, CD68 þ macrophages have been detected in close association with nerve fibers. 6 Studies investigating macrophage activation and recruitment have revealed that endometriosis-associated macrophages exhibit a phenotype consistent with the alternative end of the macrophage activation spectrum. 7,8 In a mouse model of endometriosis that included cell transfer of polarized macrophages, Bacci et al 7 reported that mice injected with proinflammatory macrophages [macrophage (interferon g)] developed microscopic lesions, but those injected with alternatively activated macrophages [macrophage (IL-4)] developed larger lesions with a well-developed vasculature. Our studies in a mouse model of endometriosis have revealed that macrophages resident in peritoneal lesions can originate from both the peritoneum and the endometrium. 9

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“…Although the endometrial biopsy was a direct one, this was an invasive test. Furthermore, the interpreta tion of biopsied specimens seemed to differ between histopathologists [3]. For these reasons, diagnosis of the LPD in clinical practice could be difficult, and the treatment of the LPD was not correlated with conception after treatment.…”

Section: Introductionmentioning

confidence: 99%

Hysteroscopic Assessment of Midsecretory-Phase Endometrium, with Special Reference to the Luteal-Phase Defect

et al. 1992

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To investigate the functional aspects of secretory-phase endometrium, hysteroscopy was performed in 61 patients for in vitro fertilization-embryo transfer (IVF-ET), and 50 women for infertility evaluation. All women had normal ovulatory cycles. The hysteroscopic assessment of secretory-phase endometrium was made by characterizing the glandular openings (GO) and vasculature. The assessments were classified as ‘good’: characterized by ring-type GO and well-developed vessels; and ‘poor’: characterized by dot and/or punctate-type GO and fine vasculature. In the 30 patients classified ‘good’ prior to the IVF cycle, there was a higher pregnancy rate (40%) than in ‘poor’ ones (13%). Thirty of 50 infertile women were classified ‘good’, and their average age was lower than that of the remaining 20 in the ‘poor’ group. Preovulatory estradiol was significantly higher in the ‘good’ than in the ‘poor’ group. From an analysis of 20 patients with a ‘poor’ assessment, it was demonstrated that the maturation of secretory-phase endometrium was affected by a failure of folliculogenesis, progesterone secretion, endometrial growth and menstrual shedding.

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Correlation of Endometrial Dating with Basal Body Temperature and Menses

Cited by 131 publications

References 3 publications

Phenotypic Characterisation of the Inner and Outer Myometrium in Normal and Adenomyotic Uteri

Phenotypic Characterisation of the Inner and Outer Myometrium in Normal and Adenomyotic Uteri

Estradiol Is a Critical Mediator of Macrophage-Nerve Cross Talk in Peritoneal Endometriosis

Hysteroscopic Assessment of Midsecretory-Phase Endometrium, with Special Reference to the Luteal-Phase Defect

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