Correlation of Elevated Serum Serotonin Levels with Regular Aerobic Exercise is Associated with Alterations in Monocyte Count and Hemoglobin Levels during Winter Season

Abstract

A B S T R A C T Central fatigue pheromone is not satisfactory to explain altered serum serotonin sSER. Thus the aim of this study is to detect some potential peripheral predictors of altered sSER at rest on the day without any exercise during winter season. One hundred and one university male students aged (21.5±1.5) year's. Participants were divided into two groups: The NES (non exercising) and RES (regular aerobic exercising) subject groups. BMI was calculated for all subjects. Fasting blood samples were collected and tested for blood glucose, blood indices, lipid profile, serum serotonin, leptin vitamin B 12 , folic acid and salivary stress hormones (cortisol and DHEA). T test showed an elevation in serum serotonin levels of RES group with significant mean difference (p = 0.031) between the study groups RES and NES. Total WBC count and obesity values for mean of BMI, weight and leptin were significantly higher in NES group. Granulocytes count (R 2 = 0.114), hemoglobin levels (R 2 = 0.193), WBC count (R 2 = 0.289), LDL levels (R 2 = 0.362) and serum leptin levels (R 2 = 0.423) were selected by stepwise regression analysis as predictive variables of regular aerobic exercise for serum serotonin. These predictors together explained 42% of the variance in serum serotonin. In NES potential predictors were; monocyte count (R 2 = 0.102) and platelets count (R 2 = 0.275). This study indicates that a positive correlation between regular aerobic exercise and serum serotonin levels in winter season is associated with significant changes in monocyte count.

Recent Trends in the Quantification of Biogenic Amines in Biofluids as Biomarkers of Various Disorders: A Review

“…They belong also to the most sensitive of all quantification methods [108]. Therefore, immunoassays were applied for the quantification of metanephrines in plasma and urine [109,110], while enzyme-linked immunosorbent assay (ELISA) was used to determine DA, NE, 5-HT and a sulphate derivative of dehydroepiandrosterone (DHEAS) in spot urine [111], as well as DA, NE and 5-HT in serum samples [112,113]. However, immunoassays also possess serious limitations.…”