Correlation of ejection fraction and infarct size estimated from the total CK released in patients with acute myocardial infarction.

Abstract

SUMMARY In order to investigate the relation between infarct size in acute myocardial infarction and left ventricular ejection fraction early after recovery, total creatine kinase released was calculated by the modified method of Sobel et al. (1972) from the serial determinations of serum CK activity; left ventriculography and selective coronary arteriography were performed at a mean of 2 months after the onset of infarction in 34 patients with acute myocardial infarction. Of 34 patients, 32 (94%) had left ventricular asynergy. In 21 patients with akinesis and/or dyskinesis, a significant correlation was found between the extent of thenon-contractingsegmentof theleft ventricle and left ventricular ejection fraction, indicating that the extent of the non-contracting segment contributes largely to reduction of ejection fraction in patients with myocardial infarction.A close inverse correlationwas also observed between theinfarct size and ejection fraction after anterior and after inferior infarction, though cardiac index was maintained over 2-0 1/min per m2 in all except 3 patients. The ejection fraction in patients with anterior myocardial infarction was lower than in those patients with inferior myocardial infarction with comparable values of total CK released. This was true even after exclusion of 6 patients with proximal right coronary artery lesions who might have had right ventricular necrosis as well as left, indicating that left ventricular function after infarction depends in part on the site of the infarct.Since Harrison (1965) In the present study, we attempted to estimate infarct size by calculating the total CK released from infarcted myocardium using the method of Sobel et al. (1972)

High Early Peak Creatine Kinase after Thrombolysis in Patients with Acute Anterior infarction Predicts Poor Left Ventricular Function

“…However, it is important to remember that the largest of these studies [23] included only 36 patients who were treated with thrombolytic ther apy and that the regression line in all these studies [7,12,13,21,23] was steeper and shifted from that of patients treated conventionally. Similar results were also demon strated in experimental studies with canine models of reperfusion [3,14].…”

Subchronic administration of Catha edulis F. (khat) extract is marked by elevation of cardiac biomarkers and subendocardial necrosis besides blood pressure alteration in rats

“…It is reported that infarct size can be estimated from total CK released and is directly related to the area of abnormally contracting segment. However, elevated total CK might not precisely indicate the occurrence of MI as its levels may also be elevated due to muscle damage or acute renal failure (Hori et al, 1979). Khat extract induced dose-dependent elevations of total CK and AST following sub-chronic administration.…”

Timing of stress testing in an asymptomatic survivor of inferior myocardial infarction.

“…Several echocardiographic and radionuclide angiographic studies attest to the same conclusion. The other prognostic determinant in the post infarction patient is significant coronary artery disease in the noninfarcted myocardium.3),4),14),18) Exercise electrocardiography with or without thallium-201 scintigraphy has had a good track record in predicting future cardiac events in patients showing ischemia with stress.1)-3),14), 15) Early (predischarge) exercise electrocardiographic results have been utilized to predict future cardiac events and assess the patient for cardiac rehabilitation. Early testing is especially favored since most cardiac events occur early after the first infarction and usually within the first 6 months.…”