Correlation of dynamic contrast‐enhanced MRI perfusion parameters with angiogenesis and biologic aggressiveness of rectal cancer: Preliminary results

Yeo, Dong-Myung; Oh, Soon Nam; Jung, Chan-Kwon; Lee, Myung Ah; Oh, Seong Taek; Rha, Sung Eun; Jung, Seung Eun; Byun, Jae Young; Gall, Peter; Son, Yohan

doi:10.1002/jmri.24541

Cited by 81 publications

(68 citation statements)

References 28 publications

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“…This result was consistent with the previous study[7]. This differed from other studies: negative correlation between K trans and MVD[9] and no association [6,8,19] (Table5).…”

Section: Discussionsupporting

confidence: 92%

“…Several studies have attempted to demonstrate correlation between DCE MRI perfusion parameters and angiogenic factors[6–10], with variable results. The only study regarding breast DCE MRI demonstrated positive correlation between K trans , k ep and MVD in benign and malignant profiles of breast disease[7].…”

Section: Introductionmentioning

confidence: 99%

“…The only study regarding breast DCE MRI demonstrated positive correlation between K trans , k ep and MVD in benign and malignant profiles of breast disease[7]. Previous studies placed a region of interest (ROI) in a small area surrounding tumor periphery or on the largest area on a single axial scan[8–10] and small areas of high K trans values within the tumor[6]. These methods resulted in observer bias and insufficient information regarding tumor heterogeneity.…”

Section: Introductionmentioning

confidence: 99%

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Dynamic Contrast-Enhanced MRI Perfusion Parameters as Imaging Biomarkers of Angiogenesis

et al. 2016

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Hypoxia in the tumor microenvironment is the leading factor in angiogenesis. Angiogenesis can be identified by dynamic contrast-enhanced breast MRI (DCE MRI). Here we investigate the relationship between perfusion parameters on DCE MRI and angiogenic and prognostic factors in patients with invasive ductal carcinoma (IDC). Perfusion parameters (Ktrans, kep and ve) of 81 IDC were obtained using histogram analysis. Twenty-fifth, 50th and 75th percentile values were calculated and were analyzed for association with microvessel density (MVD), vascular endothelial growth factor (VEGF) and conventional prognostic factors. Correlation between MVD and ve50 was positive (r = 0.33). Ktrans50 was higher in tumors larger than 2 cm than in tumors smaller than 2 cm. In multivariate analysis, Ktrans50 was affected by tumor size and MVD with 12.8% explanation. There was significant association between Ktrans50 and tumor size and MVD. Therefore we conclude that DCE MRI perfusion parameters are potential imaging biomarkers for prediction of tumor angiogenesis and aggressiveness.

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“…This result was consistent with the previous study[7]. This differed from other studies: negative correlation between K trans and MVD[9] and no association [6,8,19] (Table5).…”

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dynamic Contrast-Enhanced MRI Perfusion Parameters as Imaging Biomarkers of Angiogenesis

et al. 2016

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“…Similar to our findings, tumor K trans values have recently been shown to be lower in N1 patients compared with N0 patients. 29 To our knowledge, associations between DSC-MRI and histopathologic data have not been reported in rectal cancer patients. However, a recent study by Goh et al showed that primary colorectal tumor blood flow measured by perfusion computed tomography (CT) was significantly lower in patients with metastatic relapse compared with disease-free patients.…”

Section: Discussionmentioning

confidence: 81%

“…This result is in agreement with that of a recent study showing a significantly higher mean k ep in T1 stage tumors compared with T2-4 stage tumors. 29 A difference was found between the two readers when evaluating the association between histopathologic data and the DCE-and DSC-MRI derived parameters. This may be caused by a lower interobserver agreement in T1-and T2-stage tumor volumes, compared with T3-and T4-stage tumor volumes.…”

Section: Discussionmentioning

confidence: 98%

Dynamic multi-echo DCE- and DSC-MRI in rectal cancer: Low primary tumor K^trans and ΔR2* peak are significantly associated with lymph node metastasis

Grøvik

Redalen

Storås

et al. 2016

J. Magn. Reson. Imaging

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Purpose: To implement a dynamic contrast-based multi-echo MRI sequence in assessment of rectal cancer and evaluate associations between histopathologic data and the acquired dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast (DSC) -MRI parameters. Materials and Methods: This pilot study reports results from 17 patients with resectable rectal cancer. Dynamic contrast-based multi-echo MRI (1.5T) was acquired using a three-dimensional multi-shot EPI sequence, yielding both DCE-and DSC-data following a single injection of contrast agent. The Institutional Review Board approved the study and all patients provided written informed consent. Quantitative analysis was performed by pharmacokinetic modeling on DCE data and tracer kinetic modeling on DSC data. Mann-Whitney U-test and receiver operating characteristics curve statistics was used to evaluate associations between histopathologic data and the acquired DCE-and DSC-MRI parameters. Results: For patients with histologically confirmed nodal metastasis, the primary tumor demonstrated a significantly lower K trans and peak change in R Ã 2 , R Ã 2 -peak enh , than patients without nodal metastasis, showing a P-value of 0.010 and 0.005 for reader 1, and 0.043 and 0.019 for reader 2, respectively. Conclusion: This study shows the feasibility of acquiring DCE-and DSC-MRI in rectal cancer by dynamic multi-echo MRI. A significant association was found between both K trans and R Ã 2 -peak enh in the primary tumor and histological nodal status of the surgical specimen, which may improve stratification of patients to intensified multimodal treatment.

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A Nanostrategy for Efficient Imaging‐Guided Antitumor Therapy through a Stimuli‐Responsive Branched Polymeric Prodrug

Cai¹,

Dai

Wang³

et al. 2020

Advanced Science

176

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A stimuli‐responsive polymeric prodrug‐based nanotheranostic system with imaging agents (cyanine5.5 and gadolinium‐chelates) and a therapeutic agent paclitaxel (PTX) is prepared via polymerization and conjugating chemistry. The branched polymeric PTX‐Gd‐based nanoparticles (BP‐PTX‐Gd NPs) demonstrate excellent biocompatibility, and high stability under physiological conditions, but they stimuli‐responsively degrade and release PTX rapidly in a tumor microenvironment. The in vitro behavior of NPs labeled with fluorescent dyes is effectively monitored, and the NPs display high cytotoxicity to 4T1 cells similar to free PTX by impairing the function of microtubules, downregulating anti‐apoptotic protein Bcl‐2, and upregulating the expression of Bax, cleaved caspase‐3, cleaved caspase‐9, cleaved‐PARP, and p53 proteins. Great improvement in magnetic resonance imaging (MRI) is demonstrated by these NPs, and MRI accurately maps the temporal change profile of the tumor volume after injection of NPs and the tumor treatment process is also closely correlated with the T1 values measured from MRI, demonstrating the capability of providing real‐time feedback to the chemotherapeutic treatment effectiveness. The imaging‐guided chemotherapy to the 4T1 tumor in the mice model achieves an excellent anti‐tumor effect. This stimuli‐responsive polymeric nano‐agent opens a new door for efficient breast cancer treatment under the guidance of fluorescence/MRI.

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Correlation of dynamic contrast‐enhanced MRI perfusion parameters with angiogenesis and biologic aggressiveness of rectal cancer: Preliminary results

Cited by 81 publications

References 28 publications

Dynamic Contrast-Enhanced MRI Perfusion Parameters as Imaging Biomarkers of Angiogenesis

Dynamic Contrast-Enhanced MRI Perfusion Parameters as Imaging Biomarkers of Angiogenesis

Dynamic multi-echo DCE- and DSC-MRI in rectal cancer: Low primary tumor K^trans and ΔR2* peak are significantly associated with lymph node metastasis

A Nanostrategy for Efficient Imaging‐Guided Antitumor Therapy through a Stimuli‐Responsive Branched Polymeric Prodrug

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Correlation of dynamic contrast‐enhanced MRI perfusion parameters with angiogenesis and biologic aggressiveness of rectal cancer: Preliminary results

Cited by 81 publications

References 28 publications

Dynamic Contrast-Enhanced MRI Perfusion Parameters as Imaging Biomarkers of Angiogenesis

Dynamic Contrast-Enhanced MRI Perfusion Parameters as Imaging Biomarkers of Angiogenesis

Dynamic multi-echo DCE- and DSC-MRI in rectal cancer: Low primary tumor Ktrans and ΔR2* peak are significantly associated with lymph node metastasis

A Nanostrategy for Efficient Imaging‐Guided Antitumor Therapy through a Stimuli‐Responsive Branched Polymeric Prodrug

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Dynamic multi-echo DCE- and DSC-MRI in rectal cancer: Low primary tumor K^trans and ΔR2* peak are significantly associated with lymph node metastasis