Correlation of D dimer and factor VIII levels with histopathology in patients with breast carcinoma

Khangarot, Shyamveer Singh; Gupta, Nikhil; Goswami, Binita; Hadke, Niladhar S.; Lal, Pawanindra; Gupta, Naresh; Khurana, Nita

doi:10.3233/cbm-2010-0196

Cited by 10 publications

(12 citation statements)

References 25 publications

(36 reference statements)

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“…Also, we correlated PLR and LPLR with d-dimers, marker suggestive of active fibrinolysis and also emerging biomarker of aggressive types of breast cancer [28, 29], as well as with the neutrophil to lymphocyte ratio (NLR), which is independent prognostic factor of survival in various types of cancer and breast cancer included [4–6]. At last, due to the relative small sample of our cancer patients and the considerable number of inconclusive histopathological reports regarding the overexpression or absence of hormonal receptors in the resected specimens, we did not correlate the abovementioned laboratory parameters with immunohistochemical data.…”

Section: Methodsmentioning

confidence: 99%

Enhancing the Accuracy of Platelet to Lymphocyte Ratio after Adjustment for Large Platelet Count: A Pilot Study in Breast Cancer Patients

Seretis

Lagoudianakis

et al. 2012

International Journal of Surgical Oncology

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Background. The objective of our study is to investigate the potential effect of adjusting preoperative platelet to lymphocyte ratio, an emerging biomarker of survival in cancer patients, for the fraction of large platelets. Methods. A total of 79 patients with breast neoplasias, 44 with fibroadenomas, and 35 with invasive ductal carcinoma were included in the study. Both conventional platelet to lymphocyte ratio (PLR) and the adjusted marker, large platelet to lymphocyte ratio (LPLR), were correlated with laboratory and histopathological parameters of the study sample. Results. LPLR elevation was significantly correlated with the presence of malignancy, advanced tumor stage, metastatic spread in the axillary nodes and HER2/neu overexpression, while PLR was only correlated with the number of infiltrated lymph nodes. Conclusions. This is the first study evaluating the effect of adjustment for large platelet count on improving PLR accuracy, when correlated with the basic independent markers of survival in a sample of breast cancer patients. Further studies are needed in order to assess the possibility of applying our adjustment as standard in terms of predicting survival rates in cancer.

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Section: Methodsmentioning

confidence: 99%

Enhancing the Accuracy of Platelet to Lymphocyte Ratio after Adjustment for Large Platelet Count: A Pilot Study in Breast Cancer Patients

Seretis

Lagoudianakis

et al. 2012

International Journal of Surgical Oncology

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“…D-dimer levels >0.55 mg/l were considered to be elevated, since this was the upper limit of the 90% confidence interval for the average value determined in the healthy volunteers. The D-dimer levels in tumor patients can be affected following surgery (25,26), chemotherapy (27,28) and adjuvant therapy (29). Therefore, the data analyzed herein is the D-dimer expression level of all patients prior to treatment.…”

Section: Introductionmentioning

confidence: 99%

D‑dimer as a potential clinical marker for predicting metastasis and progression in cancer

et al. 2018

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D-dimer is a widely used biomarker for indicating the activation of coagulation and fibrinolysis, and is reported to serve important roles in cancer progression. The aim of the current retrospective study was to investigate the association of D-dimer plasma level with the development of various cancers. Patients with breast (n=86), gastric (n=317), pancreatic (n=37), colon (n=153) and rectal (n=137) cancers and 92 healthy volunteers were assessed in the present study. Plasma levels of D-dimer in the patients and healthy controls were measured by immunoturbidimetric assays. The association of D-dimer levels with the clinicopathological features of patients were also determined. The plasma levels of D-dimer were significantly higher in patients with breast cancer (P=0.0022), gastric cancer (P<0.0001), pancreatic cancer (P=0.0003), colon cancer (P=0.0001) and rectal cancer (P=0.0028), compared with the healthy controls. It was also determined that the plasma D-dimer levels were positively associated with clinical cancer stage (P<0.05) and metastasis (P<0.05). These findings suggested that the plasma D-dimer level may be used as marker for predicting cancer metastasis and progression.

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“…The involvement of axillary lymph nodes, larger size of the tumour, hormone receptor negativity, presence of the mutation of p53 and vascular invasion determine poor prognosis and treatment options upon initial diagnosis. [1,2] There is evidence that the components of the coagulation / fibrinolytic system play a role in cancer biology and angiogenesis. At the time of diagnosis, majority of the cancer patients have laboratory evidence of systemic coagulation activation.…”

Section: Introductionmentioning

confidence: 99%

“…In patients with operable breast cancer, D-dimer levels have been shown to be elevated at the time of diagnosis and to decrease during adjuvant chemotherapy. [2,4] Determining lymph node status via standard lymph node dissection creates many significant long-term side effects and many attempts have been made to predict lymph node status without undergoing a full lymph node dissection. A significant relationship has been noted between presence of elevated D-dimer and involved axillary lymph nodes.…”

Section: Introductionmentioning

confidence: 99%

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D-Dimer Levels In Breast Carcinoma: A Clinico-Pathologic Study

Patel

Rashmi

Harish

2018

APALM

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Background: Breast cancer is the most common cause of death in women by neoplasia. Plasma D-dimer is a hypercoagulability and fibrinolytic system marker, which is produced when factor XIIIa (a cross-linked fibrin) is degraded by plasmin. It is increased in various solid tumour patients including breast, lung, prostate, cervical and colorectal cancers.Methods: 30 patients of breast carcinoma who underwent radical mastectomy (cases) and 30 cases without carcinoma (controls) were included. The baseline parameters (D-dimer levels) were measured in both cases and controls. From each patient, whole blood was collected and Quantitative D-dimer levels were obtained by Diazyme's D-dimer Assay using the instrument, RANDOX Rx imola. Other parameters such as histopathological features, hormonal receptors (ER & PR) and HER2/neu status were studied in cases.Result: Mean plasma D-dimer levels were significantly higher in patients with breast carcinoma before surgery as compared to after surgery (p<0.001). Quantitative D-dimer levels highly correlated with lymph node status and histopathological grading (p=0.003, p=0.015 respectively). Conclusion:Our study showed that high plasma D-dimer levels can be used as a marker for lymph node involvement and higher histopathological grade. Due to the ease with which plasma D-dimer levels can be obtained and its cost effectiveness, quantitative D-dimer levels can be added to models for predicting axillary lymph node involvement.

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Correlation of D dimer and factor VIII levels with histopathology in patients with breast carcinoma

Cited by 10 publications

References 25 publications

Enhancing the Accuracy of Platelet to Lymphocyte Ratio after Adjustment for Large Platelet Count: A Pilot Study in Breast Cancer Patients

Enhancing the Accuracy of Platelet to Lymphocyte Ratio after Adjustment for Large Platelet Count: A Pilot Study in Breast Cancer Patients

D‑dimer as a potential clinical marker for predicting metastasis and progression in cancer

D-Dimer Levels In Breast Carcinoma: A Clinico-Pathologic Study

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